Conserved Protein Domain Family
RING-HC_ScPSH1-like
?
cd16568: RING-HC_ScPSH1-like 
RING finger, HC subclass, found in Saccharomyces cerevisiae POB3/SPT16 histone-associated protein 1 (ScPSH1) and similar proteins
ScPSH1 is a Cse4-specific E3 ubiquitin ligase that interacts with the kinetochore protein Pat1 and targets the degradation of budding yeast centromeric histone H3 variant, CENP-ACse4, which is essential for faithful chromosome segregation. ScPSH1 contains a C3HC4-type RING-HC finger and a DNA directed RNA polymerase domain.
Links
?
Statistics
?
PSSM-Id: 438230
Aligned: 12 rows
Threshold Bit Score: 80.8764
Created: 26-Apr-2016
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #                    # #  #  #                #  #        
Q12161         24 IIESLVCSICHDYMFVP---------MMTPCGHNYCYGCLNTWFasn--tqKELACPQCRSDITTIP 79   Saccharomyces cerevisiae S...
PNS20525       78 LRQTLTCRICEKLFYEP---------YVLHCGHTYCYRCLSTWFss----yRNMSCPDCRVRIKQTP 131  Sphaceloma murrayae
XP_004178628   24 ILDSTVCSICQDYMFVP---------MVTPCGHSFCYGCLCSWFsss--nvDGLSCPHCRTSITSAP 79   Tetrapisispora blattae CBS...
SLM17236       24 LLDTTICSICHDYMFVP---------MTTECGHSYCYTCLKTWFssd-tnrDGLSCPECRAIVNRIP 80   [Candida] glabrata
RMX87540       77 MRDLVTCQICHRFMYEP---------YALSCGHTYCYTCLSQWLgs----nKKKTCPDCRMVITQQP 130  Hortaea werneckii
XP_003956949   27 YIETSKCNICHEILSIPm--------MVTPCGHTYCYECLLTWFknn--enRELNCPDCRVSIEVEP 83   Kazachstania africana CBS ...
SMN20503       25 LLESCQCGICHEFLSEP---------MMISCGHNYCYKCLKNWFtsn--atRELNCPSCREPVVNEP 80   Kazachstania saulgeensis
OQU96108       19 IRSLSVCKICMRSLYEP---------YVLSCGHTYCYTCLASWFggaqrrnKSKSCPDCRTKIMTQP 76   Cladophialophora immunda
O42845        183 TTVPQECGLCMMCVQRGdervaittpYTTDCGHTYCYACIMSRLkl----vNNVSCPICKHRIRFAL 245  Schizosaccharomyces pombe ...
Q9P3U8         79 IKKTLECPICTEALQRP---------FTTHCGHTYCYECLLNWLk------ESKSCPTCRQKLYTQP 130  Schizosaccharomyces pombe ...
Q9UTL9       1086 AESHQICIICRDIIKQG---------FITTCGHLYCSFCLEAWLk------HSSSCPMCKTKLNKNN 1137 Schizosaccharomyces pombe ...
RMZ74040     1145 NNATAECIICREDIELG---------VLTTCGHHYCKDCINTWWr------VHRTCPTCKQKLSSSE 1196 Pyrenophora seminiperda CCB06

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap