Conserved Protein Domain Family
RING-HC_RSPRY1
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cd16566: RING-HC_RSPRY1 
RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
RSPRY1 is a hypothetical RING and SPRY domain-containing protein of unknown physiological function. Mutations in its corresponding gene RSPRY1 may associate with a distinct skeletal dysplasia syndrome. RSPRY1 contains a B30.2/SPRY domain and a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438228
Aligned: 15 rows
Threshold Bit Score: 70.8508
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #           # #   #  #      #  #    
Q96DX4       523 RENCCSLCCDEvADTQLKPCGHsDLCMDCALQLeTCPLCRKEI 565 human
NP_001087598 522 RENCCTLCCDElADTELRPCGHsDICMECALQLeTCPLCRQEI 564 African clawed frog
ELU18082      56 QDDSCSLCFDSaAVATLQPCGHrGMCMDCAYQLeICPLCREAI 98  Capitella sp. I Grassle & Grassle, 1976
KFQ75647     522 RENCCTVCCDEvADTELRPCGHsDLCMECALQLeTCPLCRQEI 564 Phaethon lepturus
XP_006812624 514 SEGACNLCFDKlANTILKPCDHrGLCMECAIQVeICPLCRTFI 556 Saccoglossus kowalevskii
ESO85848     493 KEDSCTLCFDKqANMELHPCGHnGFCDVCSLQLeTCPICRKPI 535 owl limpet
XP_013421219 126 KEDSCTICFDKqDTVMLLPCDHtGFCMDCAMQLeVCPLCRTNI 168 Lingula anatina
EDQ88443     665 LVDLCTICYANvPDVIHRPCDHaGFCLTCSLQVeSCPLCRRSI 707 Monosiga brevicollis MX1
XP_013783175 492 KEDSCTLCFDGkATVRLEPCDHrGFCLHCALQLeVCPMCRSPI 534 Atlantic horseshoe crab
NP_001071931 514 RADQCDLCCDLkANTTILPCKHsGICSRCVEIVdCCPFCRSEI 556 vase tunicate

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