Conserved Protein Domain Family
RING-HC_RNF186
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cd16557: RING-HC_RNF186 
RING finger, HC subclass, found in RING finger protein 186 (RNF186) and similar proteins
RNF186 is an E3 ubiquitin-protein ligase with an N-terminal C3HC4-type RING-HC finger and two putative C-terminal transmembrane domains which enable it to localize in a certain organelle. It regulates RING-dependent self-ubiquitination, as well as endoplasmic reticulum (ER) stress-mediated apoptosis through interaction with the Bcl-2 family protein BNip1.
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Statistics
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PSSM-Id: 438219
Aligned: 3 rows
Threshold Bit Score: 83.75
Created: 18-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #               # #  #  #               #  #  
Q9NXI6        37 DLECLVCREPYsc-pRLPKLLACQHAFCAICLKLLLcvqdntWSITCPLCRK 87  human
XP_007905104  18 ELECPVCFNSYeffvRKPKLLACQHGFCAICLKVILeekdgcWVVPCPLCRR 69  elephant shark
XP_014353668  17 DLECLVCCNKYdcfvRKPKLLACQHSFCAICLKLIVkemdgaWGVVCPMCRR 68  coelacanth

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