Conserved Protein Domain Family
RING-HC_RNF180
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cd16554: RING-HC_RNF180 
RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins
RNF180, also known as Rines, is a membrane-bound E3 ubiquitin-protein ligase well conserved among vertebrates. It is a critical regulator of the monoaminergic system, as well as emotional and social behavior. It interacts with brain monoamine oxidase A (MAO-A) and targets it for ubiquitination and degradation. It also functions as a novel tumor suppressor in gastric carcinogenesis. The hypermethylated CpG site count of the RNF180 DNA promoter can be used to predict survival of gastric cancer. RNF180 contains a novel conserved dual specificity protein phosphatase Rines conserved (DSPRC) domain, a basic coiled-coil domain, a C3HC4-type RING-HC finger, and a C-terminal hydrophobic region that is predicted to be a transmembrane domain.
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Statistics
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PSSM-Id: 438216
Aligned: 14 rows
Threshold Bit Score: 87.7533
Created: 12-Nov-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #            # #  #  #                 #  #             
Q86T96       428 DSYICAVCLDVYFNPyMCYPCHHIFCEPCLRTLAKd----NPSSTPCPLCRTIISRVFFQTEL 486 human
AAI58186     240 ESYICAVCLDVYFNPyMCNPCQHIFCEPCLRTIAKd----NPTKTLCPLCRATIARVCFQSEL 298 western clawed frog
AAH54692     296 DGYTCAVCLDVYYSPyKCHPCNHVFCEPCLRTLAKn----RPSNTPCPLCRTLISHVLFQEEL 354 zebrafish
ELU04313     272 EALTCSVCLELYYHPhKCEPCKHVYCGPCLRRLRAs----TPFNTKCPLCREIIWKCLPDDNL 330 Capitella sp. I Grassle & Grassl...
XP_002113939 245 ENMICPVCLDIYYRP-YRCNCGHIFCDFCIRLLAKnkldnSDPNVLCPLCRQSIKYIDDCKEL 306 Trichoplax adhaerens
EDO38979     334 DHLSCPVCLDLLFDP-FSCGCGHMFCDPCLRLLNNk---sPRKVLRCPLCRKPVNYVFPAEVT 392 starlet sea anemone
ESO82275     551 SSITCPVCLELYYHPyRVEPCGHVFCELCLRKLTTr----SCLDIPCPLCRKIIQSCQLDEEL 609 owl limpet
XP_007890422 452 EGYICAVCLDIFFSPyVCYPCHHIFCEPCLRTLAKd----NPANTPCPLCRTVITRVFFQTEL 510 elephant shark
XP_003723421 601 EVTTCSVCLDIYYQPhTCFPCEHIFCEPCLRQVTRf----HPVVTPCPLCRTTIRNVKLHDQL 659 purple urchin
XP_013415066 308 EGLTCSICLDLYYRPhSCYPCRHVFCESCLRQIANs----SSTDTVCPLCRTEIKKCILHEDL 366 Lingula anatina

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