Conserved Protein Domain Family
RING-HC_RNF170
?
cd16553: RING-HC_RNF170 
RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
RNF170, also known as putative LAG1-interacting protein, is an endoplasmic reticulum (ER) membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination-dependent degradation of type-I inositol 1,4,5-trisphosphate (IP3) receptors (ITPR1) via the endoplasmic-reticulum-associated protein degradation (ERAD) pathway. A point mutation (arginine to cysteine at position 199) in the RNF170 gene is linked with autosomal-dominant sensory ataxia (ADSA), a disease characterized by neurodegeneration in the posterior columns of the spinal cord. RNF170 contains a C3HC4-type RING-HC finger.
Links
?
Statistics
?
PSSM-Id: 438215
Aligned: 20 rows
Threshold Bit Score: 86.1879
Created: 26-Jul-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #               #  #           
Q96K19        84 DMYCPICLHQasFPVETNCGHLFCGACIIAYWRYGSWLGaiSCPICRQTVTLLLTVF 140 human
XP_002741000  89 DLQCPVCLQDaqYPTETNCGHVFCANCIITYWRHGSWLGavHCPVCRQQVTILLADF 145 Saccoglossus kowalevskii
KFM77560      34 DLQCPVCLNElrYPVETNCGHLFCAQCLITYWRHGNWMGaiRCPVCRQTVIVLLQCF 90  Stegodyphus mimosarum
ESO03968      50 NMVCPICLGPtsYPLETNCGHIFCGQCFITYWRMGRWTSavSCPSCRQRVTLLLFCF 106 Helobdella robusta
EDO34494      97 DRQCPVCITDarFLTMTNCGHEFCAPCIITYWRHGRWLGavQCPVCRQQVNLLFANF 153 starlet sea anemone
XP_013415213 112 DITCPICLNDanYAIETNCGHTFCGQCIITYWRHGSWLGavRCPVCRQQVTILLFSF 168 Lingula anatina
ETW02009      57 NSTCPICLTDvrLACETNCGHGFCTPCLTSYFASRRLDY--PCPYCRQYIHLVHTFY 111 Aphanomyces invadans
EFX74792      30 QNQCPVCLNDieYEVETNCGHIFCCRCWLAYRAHGSFLGavRCPVCRQQVTILFQGF 86  common water flea
KDR13975      90 PERCPICLHEhqMALETNCGHLYCGNCLRMYIYMNDVMSriSCPMCRQQISVLFVCF 146 Zootermopsis nevadensis
XP_004365224 149 DDACPICLQQvqFAIETNCGHVFCSPCVVEYWRHSAQMQamQCPNCRQRVTLLLPEF 205 Capsaspora owczarzaki ATCC 30864

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap