Conserved Protein Domain Family
RING-HC_RNF166
?
cd16549: RING-HC_RNF166 
RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
RNF166 is encoded by the gene RNF166 targeted by thyroid hormone receptor alpha1 (TRalpha1), which is important in brain development. It plays an important role in RNA virus-induced interferon-beta production by enhancing the ubiquitination of TRAF3 and TRAF6. RNF166, together with three closely related proteins: RNF114, RNF125 and RNF138, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).
Links
?
Statistics
?
PSSM-Id: 438211
Aligned: 7 rows
Threshold Bit Score: 73.6924
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #            # #  #  #           #  #    
Q96A37        30 QYTCPICLEVYHRPvAIGSCGHTFCGECLQPCLQVpSPLCPLCRLPF 76  human
CAF92401      41 QFSCPICLEVYHKPvSIASCAHTFCGECLQPCLQVtSPLCPLCRVPF 87  spotted green pufferfish
Q3KPU8        34 QFGCPICLEVYYKPvAIGSCGHTFCGECLQPCLQVsSPLCPLCRMPF 80  African clawed frog
Q5F3B2        37 QFSCPICLEVFHRAvGIAGCGHTFCGECLQPCLQVpSPLCPLCRMPF 83  chicken
XP_006008322  56 QYSCPICLEVYYKPvSITSCGHTFCGECLQPCLQVpSPLCPLCRMPF 102 coelacanth
XP_002737160  19 NFICSICLEVYRKP-VTITCGHTFCRECLKPCIATaAPQCPVCRAAF 64  Saccoglossus kowalevskii
XP_035679265  11 ALTCSICLEIFLKP-VTTTCGHTFCSSCIAPCLQLaSPNCPLCRVVF 56

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap