Conserved Protein Domain Family
RING-HC_RNF138
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cd16544: RING-HC_RNF138 
RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
RNF138, also known as Nemo-like kinase-associated RING finger protein (NARF) or NLK-associated RING finger protein, is an E3 ubiquitin-protein ligase that plays an important role in glioma cell proliferation, apoptosis, and cell cycle. It specifically cooperates with the E2 conjugating enzyme E2-25K (Hip-2/UbcH1), regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF), and further suppresses Wnt-beta-catenin signaling. RNF138, together with three closely related proteins: RNF114, RNF125 and RNF166, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).
Links
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Statistics
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PSSM-Id: 438206
Aligned: 11 rows
Threshold Bit Score: 68.5839
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #             # #  #  #                             #  #         
Q8WVD3         14 DDFYCPVCQEVLKt-PVRTTACQHVFCRKCFLTAmre------------------sgaHCPLCRGNVTRRER 66   human
Q1L721         13 EEFLCPVCQEILQt-PVRTQTCRHVFCRKCFMLAmks------------------ggaYCPLCRGPVNKSER 65   African clawed frog
CDQ68110       32 EDYDCPICQDVLKt-PIRTRNCRHVFCKNCFRLAvra------------------qgpHCPLCRGPVSETEK 84   rainbow trout
XP_015138091   13 EDFYCPICQEVFKt-PVRTMNCQHVFCRKCFLTAmre------------------sgtHCPLCRGSVTKKER 65   chicken
XP_001437190    3 QSYDCPICLSISVd-PIQLSQCNHIFCSACIVDLldyn----------------nqsyKCPLCRQLYQKNEP 57   Paramecium tetraureli...
CUG88904      125 AELECPVCQEALLd-PLQLEQCDHIFCAACIQLSlaat-----------------tpeRCPVCSEPGSKTQR 178 
XP_007889662    3 ASLTCAVCLSVFEs-PVTLPVCSHNFCKKCILECvtrslsgqdwssagdgniwsnsqlECPLCRKNNFIPEG 73   elephant shark
XP_016609107    9 DLLTCAICSDIYTn-PVKLPQCPHIFCKECLEHTlqs------------------carKCPLCNRFAGGGYR 61  
KPI84390       20 ALFLCPICNDSWAd-PVELVPCGDIFCRVCIHAArakhaaq----------pmimenfQCPLCHTVVQSEKK 80  
TPP44940       12 EELTCAVCLDSWKd-PVELMPCGHIFCKACATGLk-----------------------ECPVCRDPIRSTKA 59   Leishmania donovani
P23799          6 TYGMCAVCREPWAegAVELLPCRHVFCTACVVQRw-----------------------RCPSCQRRIGGRRK 54   Trypanosoma brucei br...

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