Conserved Protein Domain Family
RING-HC_TRIM77_C-IV
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cd16543: RING-HC_TRIM77_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 77 (TRIM77) and similar proteins
TRIM77 belongs to the C-IV subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including two consecutive zinc-binding domains, a C3HC4-type RING-HC finger and Bbox2, as well as a SPRY/B30.2 domain positioned C-terminal to the RBCC domain.
Links
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Statistics
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PSSM-Id: 438205
Aligned: 8 rows
Threshold Bit Score: 92.0695
Created: 17-Feb-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #           # #  #  #                #  #        
I1YAP6        10 TSELTCSICTDYLTDPVTICCGHRFCSPCLCLLWEdtl---tpnCCPVCREISQQMY 63  human
XP_029954349   3 NPNLTCIICFDQFKYPVTIPCGHTFCKNCIITLWDtksksnigpHCPICNEKFTTRP 59  jewelled blenny
TWW69034       7 EDPFSCYICFHLLEEPVTIPCGHTYCRRCITHLWDrqp----vpSCPQCLQSFSPCP 59  sansaifugu
XP_016537113   9 DSQVSCCICLDLLKDPVTIPCGHSYCMNCIKDLWDrkdq-kgiySCLHCKKTFTLRP 64  Amazon molly
XP_028672560  10 PDQVTCSVCLDMLKDPVTIPCGHNYCMNCIKNLWDrgda-sgryRCPQCRMEFNRRP 65  reedfish
XP_029988073  10 EARLCCSICLELFKDPVTIPCGHSYCMSCLTDLWDheq----tcSCPQCRASFSPRP 62  orbiculate cardinalfish
Q8VI40        10 QDKCICYICSDFMEDPVTSRCGHNFCFACLRLLWDdlq---gniFCPVCQTPFPPKS 63  house mouse
KTF89707       9 RESLSCSVCLDVFRNPVTIPCGHSFCKDCITCLWDkd-----vrRCPQCKQSFPNKP 60  common carp

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