Conserved Protein Domain Family
RING-HC_RNF37
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cd16537: RING-HC_RNF37 
RING finger, HC subclass, found in RING finger protein 37 (RNF37)
RNF37, also known as KIAA0860, U-box domain-containing protein 5 (UBOX5), UbcM4-interacting protein 5 (UIP5), or ubiquitin-conjugating enzyme 7-interacting protein 5, is an E3 ubiquitin-protein ligase found exclusively in the nucleus as part of a nuclear dot-like structure. It interacts with the molecular chaperone VCP/p97 protein. RNF37 contains a U-box domain followed by a potential nuclear location signal (NLS) and a C-terminal C3HC4-type RING-HC finger. The U-box domain is a modified RING finger domain that lacks the hallmark metal-chelating cysteines and histidines of the latter, and is likely to adopt a RING finger-like conformation. The presence of the U-box, but not of the RING finger, is required for the E3 activity. The U-box domain can directly interact with several E2 enzymes, including UbcM2, UbcM3, UbcM4, UbcH5, and UbcH8, suggesting a similar function as the RING finger in the ubiquitination pathway. This model corresponds to the RING-HC finger.
Links
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Statistics
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PSSM-Id: 438199
Aligned: 6 rows
Threshold Bit Score: 94.0414
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                 # #  #  #                  #  #     
O94941       481 PECASCKRVFspyfkkepvYQLPCGHLLCRPCLGEkqr-------slpMTCTACQRPVA 532 human
EOB08210     457 QGCASCGKTFspyfktepvYQLPCGHLLCRPCLAEkqk-------apaVACGSCKRSVA 508 mallard
NP_001088635 480 QGCSSCGRIFsaycktepvYQLSCGHLMCRPCLAEkqk-------slsVLCNNCNRTVA 531 African clawed frog
ABZ04534     409 QGCAVCSKAFspyfkaeavYRFPCGHLMCRPCLTQrqq-------sslIMCVGCEKLFA 460 Menado coelacanth
ACN32395     400 DVCIACCRAFsaycsylviYRLPCGHLICRPCLSErqk-------taaLSCLKCNQPVN 451 elephant shark
CDQ84164     543 NRCGSCSCSLsvystspsaYRLPCGHFLCRPCLHRksrplvttampnhILCPTCHSPAA 601 rainbow trout

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