Conserved Protein Domain Family
RING-HC_NHL-1-like
?
cd16524: RING-HC_NHL-1-like 
RING finger, HC subclass, found in Caenorhabditis elegans RING finger protein NHL-1 and similar proteins
NHL-1 functions as an E3 ubiquitin-protein ligase in the presence of both UBC-13 and UBC-1 within the ubiquitin pathway of Caenorhabditis elegans. It acts in chemosensory neurons to promote stress resistance in distal tissues by the transcription factor DAF-16 activation but is dispensable for the activation of heat shock factor 1 (HSF-1). NHL-1 belongs to the TRIM (tripartite motif)-NHL family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain, as well as an NHL (named after proteins NCL-1, HT2A and Lin-41 that contain repeats folded into a six-bladed beta propeller) repeat domain positioned C-terminal to the RBCC domain.
Links
?
Statistics
?
PSSM-Id: 438187
Aligned: 12 rows
Threshold Bit Score: 90.9474
Created: 22-Mar-2015
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  #           # #  #   #              #  #    
Q03601         36 KIEQLLTCPICLDRYkqPKLLPCQHTFCy-PCLESCADtl-hRNLKCPECRAEH 87   Caenorhabditis elegans
NP_001286596    3 QFEQLLTCCVCLDRYriPKLLPCQHSFCmePCMEGLVDyv-rRQVKCPECRAEH 55   fruit fly
XP_007888996    5 LIEQLLTCPVCLDRYkrPKLLPCQHTFCqePCLKGLVNev-nRKVKCPECRAVH 57   elephant shark
XP_002736356    4 QIEELLNCAVCLERYnrPKILPCQHTFCqsPCLENLIDir-vRKLKCPECRMEH 56   Saccoglossus kowalevskii
ELU03822       31 QVERLLTCAICLERYtnPRILPCQHTFCrsPCLDGLVDlr-nRKVKCPECRKEH 83   Capitella teleta
XP_009860351    4 QLETLVTCAVCLDRFvhPKILPCQHTFClkPCLQNLVId---KSIRCPHCRTIH 54   vase tunicate
KOF66468       10 QVQQLLRCAICLDRFrqPKLLPCQHTFCesPCLEGLVDyy-tRRIKCPECRLEH 62   Octopus bimaculoides
XP_013420834   10 QIDELLKCAICLDRFrnPKLLPCQHTFCesPCLEGLLTag-sRVLKCPECRSEH 62   Lingula anatina
EEC00424       24 SLKEMVQCPICLDRLhrPKMLPCQHAFCf-LCLQNSVMkadtSKLRCAKCRTEV 76   black-legged tick
EFX79740        3 QFDQLLTCCVCLDRYrnPKLLPCQHSFCmePCMEGLINyv-tRQVKCPECRAEH 55   common water flea
XP_005995479   13 QIEQLLTCPICLDRYqrPKVLPCQHTFClePCLERLASnt-tKQLKCPECRAVH 65   coelacanth
VDN02807       48 KIEQLLTCPICLDRYkqPKLLPCHHTFCl-SCLDNCVDvv-hRILKCPECRAEH 99   thelaziosis nematode

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap