2CS3


Conserved Protein Domain Family
vRING-HC_IRF2BP1-like
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cd16511: vRING-HC_IRF2BP1-like 
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variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
This subfamily includes IRF-2BP1, IRF-2BP2, and their homolog, IRF-2BP-like, also known as IRF-2BPL or C14orf4. IRF-2BP1 and IRF-2BP2 are nuclear proteins that bind to the C-terminal repression domain of IRF-2 and act as IRF-2-dependent transcriptional corepressors, both enhancer-activated and basal transcription. IRF-2BPL is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. All subfamily members contain a C-terminal variant C3HC4-type RING-HC finger.
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Statistics
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PSSM-Id: 438174
Aligned: 20 rows
Threshold Bit Score: 102.884
Created: 5-Aug-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2CS3; Homo sapiens IRF-2BPL binds two Zn2+ ions through its RING-HC finger.
  • Comment:variant RING-HC finger (C3HC4-type)
  • Comment:typical C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
  • Comment:The C3HC4-type RING-HC finger of Homo sapiens IRF-2BPL shows a partially new pattern by comparing with the typical C3HC4-type RING-HC finger. The third, sixth and seventh conserved Cys residues are in different positions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           #     #  #  #                 #     #    
2CS3_A        16 LCCTICHERLEDTHFVQCPSVpsHKFCFPCSRESIKaqg--atgEVYCPSGEKCPLVG 71  human
ELT98049     476 LKCTLCNERLEDTHFVQCPSVseHKFCFPCSRDSIKrqg--agaEVYCPSGKKCPLVG 531 Capitella sp. I Grassle & Grassle, 1976
EFX75404     573 LKCTICQERLEDTHFVQCPSIshHKFCFPCSRDSIKqqg--agsEVYCPSGEKCPLAG 628 common water flea
EEC12624     361 LKCTLCQERLEDTHFVQCPSVgqHKFCFPCSRDSIKsqgassgsEVYCPSGEKCPLVG 418 black-legged tick
XP_784488    578 LKCTLCHERLEDTHFVQCPSVsnHKFCFPCSRDSIKkqg--sgsEVYCPSGAKCPLAG 633 purple sea urchin
NP_506317    296 LRCTLCNERLEDTHFVQCPTVsiHKFCFPCSRSSIKdqc--kssDMYCPSGDKCPLVG 351 Caenorhabditis elegans
XP_003385563 448 MECLICHKALDDTRFVQCPSMgpHKFCFSCSRDSIKqqvs-sskDVYCPSGLKCLVQG 504 Amphimedon queenslandica
NP_001259486 501 LKCTLCQERLEDTHFVQCPSVnhHKFCFPCSRESIKrqng-lgnEVYCPSGDRCPLAN 557 fruit fly
EDO43062     247 LRCSLCRDKLEDTHFVQCPSImhHKFCFPCSRDSIKkqg--agtEVFCPSGERCPLQG 302 starlet sea anemone
XP_013407679 524 LKCTLCQERLEDTHFVQCPSVgdHKFCFPCSRESIKrqg--pgsEVYCPSGKKCPLVG 579 Lingula anatina

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