Conserved Protein Domain Family
RING-HC_CYHR1
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cd16505: RING-HC_CYHR1 
RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
CYHR1, also known as cysteine/histidine-rich protein (Chrp), shows sequence similarity with the Drosophila RING finger protein Seven-in-Absentia (sina) and its murine and human siah homologs. It is a novel prognostic marker that may work as a therapeutic target in patients with esophageal squamous cell carcinoma. It is also a biomarker of the response to erythropoietin in hemodialysis patients. CYHR1 contains an N-terminal C3HC4-type RING-HC finger and a C-terminal tumor necrosis factor (TNF) receptor associated factor (TRAF)-like substrate-binding domain (SBD).
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Statistics
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PSSM-Id: 438168
Aligned: 14 rows
Threshold Bit Score: 99.837
Created: 31-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #  #          #   #  #  #                #  #      
Q08CH8        71 KLEERLYSVLCCTVCLDLPKaSVYQCTNGHLMCAGCFIHLLADSRLKEEqATCPNCRCEISK 132 zebrafish
Q2TAD9        61 RLEERLYSVLCCAVCLDLPKaSVYQCTNGHLMCAGCFIHLLADARLKEEqATCPNCRCEISK 122 African clawed frog
ELT87328      33 KLEERLSGILCCAVCLDLPKvAVYQCTNGHLMCAGCLAHLLADARLKDEeATCPNCRCDISK 94  Capitella sp. I Grassle & Grassle...
EFX90213      50 RLETRLGGILCCSVCLDLPSsAVYQCSNGHLSCVGCFNHLLADARMRDEtATCPNCRTEISK 111 common water flea
XP_003229417  87 KLEERLYSVLCCTVCLDLPKaSVYQCTNGHLMCAGCFIHLLADARLKEEqATCPNCRCEISK 148 green anole
XP_784749     46 NLEDRLNEILCCTVCLDLPTfTIYQCNNGHLMCAGCFTHLLADSRLKDEqPTCPNCRCEISK 107 purple sea urchin
XP_002736139  21 KLEQRLNGILCCAVCLDLPRsTVFQCTNGHLMCAGCFTHLLADARLKNEqATCPNCRCEISK 82  Saccoglossus kowalevskii
NP_001123341  36 KLEERLNHILSCTVCLDLPTsACMQCCHGHLMCVGCYHHLLADARLKDEqATCPSCRVDITR 97  vase tunicate
KFM69606      48 ALEERLNGILCCAVCLDLPKsSVYQCRNGHLVCSDCFNHLLADAQLRMGtAVCPSCRTLISK 109 Stegodyphus mimosarum
Q9VZV5       102 KLAHRISNALCCAVCLDLPKtAMYQCQMGHLMCAACFTHLLADGRLRDQiATCPNCRVEISK 163 fruit fly

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