Conserved Protein Domain Family
mRING-H2-C3H2C2D_ZSWM2
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cd16486: mRING-H2-C3H2C2D_ZSWM2 
Modified RING finger, H2 subclass (C3H2C2D-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
ZSWIM2, also known as MEKK1-related protein X (MEX) or ZZ-type zinc finger-containing protein 2, is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis through Fas, death receptor (DR) 3 and DR4 signaling. ZSWIM2 is self-ubiquitinated and targeted for degradation through the proteasome pathway. It acts as an E3 ubiquitin ligase, through the E2, Ub-conjugating enzymes UbcH5a, UbcH5c, or UbcH6. ZSWIM2 contains four putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain critical for its ubiquitination, and two modified RING-H2 fingers separated by a ZZ zinc finger domain, which was required for interaction with UbcH5a and its self-association. This model corresponds to the second RING-H2 finger, which is not a canonical C3H2C3-type, but a modified C3H2C2D-type.
Links
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Statistics
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PSSM-Id: 438149
Aligned: 10 rows
Threshold Bit Score: 84.7324
Created: 6-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C [DC]Click to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human RBX1 with bound Zn through its C3H2C2D-type modified RING-H2 finger
  • Comment:modified RING-H2 finger (C3H2C2D-type)
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #               # #  #  #           #  #      
Q8NEG5       343 QCLLCLKAFHLGQHTRLLP-CTHKFHRKCIDNWLFHkcnSCPIDGQVIYN 391 human
ELU10326     344 QCRVCLRGYQVGQEVRQLP-CRHKFHKDCIDNRLLHqhaTCPVDGTLFTN 392 Capitella sp. I Grassle & Grassle, 1976
EDV26739     350 KCRICMLPFQIRQYVRKLP-CRHKFHVQCIDHWLMHersSCPIDGEIINP 398 Trichoplax adhaerens
XP_007888410 349 QCRICLKVFRISQHVRRLP-CNHKFHRECIDHWLLHernACPIDGEVVYH 397 elephant shark
ETE60113     265 QCRLCLKIFCLGQVTRTLP-CNHKFHRKCIDRWLQKe-nACPIDDHVVYN 312 king cobra
AAI46751     339 QCRLCLSRFQLGQCIRTLP-CKHKFHTGCIDPLLRVs-nCCPLEWHIIYN 386 zebrafish
XP_013415947 351 QCRVCLRAFQAGQQIRRLPvCKHKFHIDCIDNWLIHqrpTCPIDGQVVWS 400 Lingula anatina
XP_014351840 351 QCRICLKAFSLGQFVRQLP-CRHKFHKECIDYLLLNernSCPLDGQVIYN 399 coelacanth
XP_004365669 374 VCTVCLMPFDAQQTVRTLS-CGHEFHRDCIDNWLSQsslNCPVDNLPVTT 422 Capsaspora owczarzaki ATCC 30864
EDQ31208     243 ECTICLESFILKDKMRVLP-CNHCFHTSCIDNWLLTs-lNCPICRKSVSK 290 Enterocytozoon bieneusi H348

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