2LXP,4LAD,2LXH


Conserved Protein Domain Family
RING-H2_AMFR
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cd16455: RING-H2_AMFR 
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RING finger, H2 subclass, found in autocrine motility factor receptor (AMFR) and similar proteins
AMFR, also known as AMF receptor, or RING finger protein 45, or ER-protein gp78, is an internalizing cell surface glycoprotein localized in both plasma membrane caveolae and the endoplasmic reticulum (ER). It is involved in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. AMFR also functions as a RING finger-dependent ubiquitin protein ligase (E3) implicated in the degradation from the ER. AMFR contains an N-terminal RING-H2 finger and a C-terminal ubiquitin-associated (UBA)-like CUE domain.
Links
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Statistics
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PSSM-Id: 438119
Aligned: 19 rows
Threshold Bit Score: 81.7259
Created: 26-Jan-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteE2 binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2LXP; Homo sapiens AMFR (also known as ubiquitin ligase GP78) binds two Zn2+ through its RING-H2 finger.
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #  #  #              #  #    
2LXP_C        13 DDCAICWDSMqaARKLPCGHLFHNSCLRSWLEQDt----SCPTCRMSL 56  human
KFM75662     152 DDCAICWDHLdlARKLPCGHLFHNSCLRSWLEQDt----SCPTCRKAL 195 Stegodyphus mimosarum
ELT96861     336 DDCAVCWEKMdtARKLPCGHLFHNACLRSWLEQDa----SCPTCRTSL 379 Capitella teleta
XP_002127598 420 DQCAICWEQMetARKLPCGHFFHSPCLRSWLEQDt----TCPTCRKQL 463 vase tunicate
XP_002735082 451 DDCAICWDRMasARKLPCGHLFHNSCLRSWLEHDt----SCPTCRTSL 494 Saccoglossus kowalevskii
XP_013379354 354 DKCAICWEKMksGRTLPCGHIFHSFCLRSWLEQDv----SCPTCREAL 397 Lingula anatina
XP_002112114 257 QKCAICWEKLesARKLPCTHLFHSSCLQSWLEQDt----TCPTCRLSL 300 Trichoplax adhaerens
XP_013083868 300 DDCAICWEKMesARKLPCGHLFHNSCLRSWLEQDs----SCPTCRTRL 343 Biomphalaria glabrata
XP_024392413 332 DDCAICKEPMatAKRLPCAHLFHLTCLRSWLDQGlaetySCPTCRRPL 379 Physcomitrium patens
EFJ09982     286 DDCAICKEPMvkAKRLPCAHLFHLSCLRSWLDQGladtySCPTCRRPL 333 Selaginella moellendorffii

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