1H0H,1KQG


Conserved Protein Domain Family
FDH_beta_like
?
cd16366: FDH_beta_like 
Click on image for an interactive view with Cn3D
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins
This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.
Links
?
Statistics
?
PSSM-Id: 319888
Aligned: 10 rows
Threshold Bit Score: 234.986
Created: 15-Jan-2016
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Fe-S cluster
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Structure:1KQG: Escherichia coli formate dehydrogenase N binds to 4[Fe-S] clusters; contacts at 4A distance.
  • Structure:1H0H: Desulfovibrio gigas formate dehydrogenase binds to 3[Fe-S] clusters; contacts at 4A distance.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        #      #### ##   #   #                         # #                        #  ###
1H0H_B         4 FFVDTTRCTACrGCQVACKQWHgnpatptentg-fhqnppdfnfhTYKLVRMHeqeidg--------ridwlFFPDQCRH 74  Desulfovibrio g...
1KQG_B        32 KLIDVSTCIGCkACQVACSEWNdirdevghcvg-vydnpadlsakSWTVMRFSeteqng--------klewlIRKDGCMH 102 Escherichia coli
WP_002630619   6 FFTDTTICIGCkACEVACKQWNqlpedgleltgmsydntghlgasTWRHVAFVerpvpmpghtvglvdfswlMSSDVCKH 85  Cystobacter fuscus
WP_008412684   5 VLVDITRCMGCkACQVACKQWNdlpsgvpefke-gltsppemngyTYTTVRIEvvekan--------dytmrSAKRQCMH 75  Desulfotomaculu...
WP_007288834   6 YCYDSSKCVGChGCQVACKQWNeektlatrfa---gsyqnppdldKDTRMVMRyyehfeq-----dtipslnFLKYQCFH 77  Thermosinus car...
ADW21629       9 ILFDASRCIGCkACQVACKQWNdleaektenrg-syanpprltahTWISMRYYeglrpd-------gdpyfdFIRGSCMH 80  Thermus scotodu...
KUK32188       6 MFIDTSKCTGCrACQVACKNWNglpaeetdfwg-tyenpktltgnTWTKVKFNekveng--------nikllFAKIQCMH 76  Thermoanaerobac...
ADG81638       6 ILVDVSKCTGCrGCQVACKQWNnlpatktkfs----gsyenpvtmNGAYTKVKfietven------gqvrflFRKIQCMH 75  Thermincola pot...
KPK90632       6 MLVDVSKCTACrACQVACKQWNglpaekteqrg-thqnppdltwaTWNLIRFTevptke-------gnlkwlFRRDACLH 77  Deltaproteobact...
ADH86080       6 RLIDITRCTACrGCQVSCKRWNqlpgeigaftg-syqshddlspgRWTMIRFYeekkgr-------gelawhFRKATCMH 77  Desulfurivibrio...

Feature 1        #    #   ##     ##        #           ####   ### ##          # #####            
1H0H_B        75 CiappCKATADmedeSAIIHDdatGCVLFTPKtkdledYESVISACPYDVPRKVae--snQMAKCDMCidrit------n 146 Desulfovibrio g...
1KQG_B       103 CedpgCLKACPs--aGAIIQYa-nGIVDFQSEnc--igCGYCIAGCPFNIPRLNke--dnRVYKCTLCvdrvs------v 169 Escherichia coli
WP_002630619  86 CqragCLEACPt---GAIIRTe-fDTVYVQPDvc--ngCGYCVTACPFGVIDRRed--dgRAWKCTLCydrlg------e 151 Cystobacter fuscus
WP_008412684  76 CehpaCASACFa---KALQKDpktGAVVYHSHlc--vgCRYCMLACPFDIPKYQwdkqfpLVAKCQFCfdpkgkydrlgy 150 Desulfotomaculu...
WP_007288834  78 CgeaaCVKVCPs---GALFKTk-tGIVAVDREkc--iaCGYCHNACPFNIPAVGk-----HVNKCDMCrsrtengqdgdk 146 Thermosinus car...
ADW21629      81 CthapCVASCPt---GAMAHRe-gGVVTVDEKtc--igCRSCVQACPYEAVHFDea--rgVVHKCTMCydris------n 146 Thermus scotodu...
KUK32188      77 CndasCMAVCAt---KAISRRp-gGMIVIDQNrc--vgCRNCVTACPFGAVNFSee--tgTPRKCRLCedrva------a 142 Thermoanaerobac...
ADG81638      76 CteasCMAVCAa---GAISRAd-nGQVVIDRDtc--igCKNCVVACPFGAIGFDee--tgTSGKCWGCqdrve------n 141 Thermincola pot...
KPK90632      78 CtdagCMRACPv--pGAIFRTp-qGAVVINQElc--igCKMCVNACPFEIPRINae--tnRAYKCTLCwdrta------r 144 Deltaproteobact...
ADH86080      78 CgdagCLKACPn---EALVQEe-nGTIRRIEEnc--igCGHCVQFCPFDIPKVDev--aqKMKKCTFCydris------n 143 Desulfurivibrio...

Feature 1             #   #    #   
1H0H_B       147 glrpACVTSCptgAMNFG 164 Desulfovibrio gigas
1KQG_B       170 gqepACVKTCptgAIHFG 187 Escherichia coli
WP_002630619 152 gmtpACAKACptaSIQYG 169 Cystobacter fuscus
WP_008412684 151 glqpACVDTCptgALKFG 168 Desulfotomaculum hydrothermale
WP_007288834 147 tnvpACVKTCpagALEFG 164 Thermosinus carboxydivorans
ADW21629     147 gdqpACVKACptdALTFG 164 Thermus scotoductus SA-01
KUK32188     143 glqpACVNAClsgALNFG 160 Thermoanaerobacterales bacterium 50_218
ADG81638     142 gltpACAKTCptgAITFG 159 Thermincola potens JR
KPK90632     145 glipACVKACamgTLTFG 162 Deltaproteobacteria bacterium SM23_61
ADH86080     144 grepACAKTCvprAIVYG 161 Desulfurivibrio alkaliphilus AHT 2

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap