1M2X


Conserved Protein Domain Family
BlaB-like_MBL-B1
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cd16316: BlaB-like_MBL-B1 
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Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) BlaB and related metallo-beta-lactamases, subclass B1; MBL-fold metallo-hydrolase domain
Includes the chromosome-encoded MBL Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) BlaB and related MBLs. MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of MBLs belongs to the B1 subclass. B1 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile.
Links
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Statistics
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PSSM-Id: 293874
Aligned: 11 rows
Threshold Bit Score: 376.419
Created: 20-Aug-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:Elizabethkingia meningoseptica BlaB metallo-beta-lactamase binds the inhibitor D-captopril and two zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   #                          # ###     
1M2X_A         2 VKIEKLKDNLYVYTTYNTFnGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHgKKVIMNIATHSHDDRAGGL 81  Elizabethkingia...
ELR79471      27 VKIDKLKDNLYVYTTYNTFnGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHgKKVIMNIATHSHDDRAGGL 106 Elizabethkingia...
AAF89161      27 IKIEKLKDNLYVYTTYNTFkGTKYAANAVYMVTDKGVVVIDSPWGEDKFKSFTDEIYKKHgKKVIMNIATHSHDDRAGGL 106 Elizabethkingia...
AAF89160      27 IKIEKLKDNLYVYTTYNTFkGTKYAANAVYMVTDKGIVVIDSPWGEDKFKSFTDEIYKKHgKKVIMNIATHSHDDRAGGL 106 Elizabethkingia...
AAF89159      28 IKIEKLKDNLYVYTTYNTFkGTKYAANAVYMVTDKGVVVIDSPWGEDKFKSFTDEIYKKHgKKVIMNIATHSHDDRAGGL 107 Elizabethkingia...
Q9XBN7        28 VKIEKLKDNLYVYTTYNTFnGTKYAANAVYLVTSKGVVVIDSPWGEEKFKNFTDEIYKRHgKKVIMNIATHSHDDRAGGL 107 Elizabethkingia...
WP_012025466  26 LQISHLTGDFYVYRTFNDYkGTKISANAMYVVTDKGVVLFDAPWDKTQFQPLLDSIKAKHnKEVVMLFGTHSHEDRAGGF 105 Flavobacterium ...
AJP77076      23 IKIKHLTGDLYVYTTYNTYkGALTDANAVYLVTNKGVVVIDAPWDATQFQPFLDSIQTKHhQKVVLAIATHSHGDRAGGL 102 Pedobacter sp. ...
ETZ21715      25 LKISHLTGDFYIFTSYYSYkGTVTPANGMYVVTNDGVIMIDAPWDSAQFQPLLDSIQVKHhKTVKIEIATHSHEDRAGGL 104 Pedobacter sp. V48
KIF31492      25 LEIVRLTGDFYIYTTYNTYqENRTPAHGMYVVTTDGVVMFDTPWDTTQFQPLLDSIQTRHhKNVIMCFATHWHSDKTAGL 104 Hassallia bysso...
KIO51907      26 LQISHLTGDFYVYKTFHDYkGTLISANAMYFVTDKGVVLFDAPWDKTQFQPLLDSIKAKHnKNVIMCFATHSHEDRAGGL 105 Flavobacterium ...

Feature 1                                #                            #                  #       
1M2X_A        82 EYFGKIGAKTYSTKMTDSILAKEnKPRAQYTFDnNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADS 161 Elizabethkingia...
ELR79471     107 EYFGKIGAKTYSTKMTDSILAKEnKPRAQYTFDnNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADS 186 Elizabethkingia...
AAF89161     107 EYFGKLGAKTYSTKMTDSILAKEnKPRAKYTFDnNKSFKVGKTEFQVYYPGKGHTADNVVVWFPKDKVLVGGCIVKSGDS 186 Elizabethkingia...
AAF89160     107 EYFGKLGAKTYSTKMTDSILAKEnKPRAKYTFDnNKSFKVGKTEFQVYYPGKGHTADNVVVWFPKDKVLVGGCIVKSGDS 186 Elizabethkingia...
AAF89159     108 EYFGKLGAKTYSTKMTDSILAKEnKPRAKYTFDnNKSFKVGNTEFQVYYPGKGHTADNVVVWFPKDKVLVGGCIVKSGDS 187 Elizabethkingia...
Q9XBN7       108 EYFKSLGAKTYSTKMTDSILAKDnKPRAQYTFDnNKSFKVGKDEFQVYYPGKGHTADHVVVWFPKDKVLVGGCIIKSGDS 187 Elizabethkingia...
WP_012025466 106 DFYKKKGIKTYSIKLTDDILKKNkEPRAEFIISnDTTFTVGNHTFEVYYPGKGHAPDNIVAWFKKEKILYGGCFVKSAEA 185 Flavobacterium ...
AJP77076     103 AFFKSKGIKTYTNKLTDEILKTNkEPRAAYTFTnDTTFTVGQYKINTYYAGKGHTKDNLVVWFPKDKVLFGGCLIKSIEA 182 Pedobacter sp. ...
ETZ21715     105 DFLRNSGAKTFTSDKTDSILKESnKKRAEFTFKrDTTIMLGQHKLSTYYAGEGHTKDNIVVWFEKEKVLYGGCLVKSTDA 184 Pedobacter sp. V48
KIF31492     105 EYYRQHGIKTYTTALTDELSKKNdMKRAEFLMTrDTTFRVGQYTFETYYPGPGHTTDNIVIWFEKEKILYGGCLIKGAGD 184 Hassallia bysso...
KIO51907     106 EFYGKKGIKTYTIKLTDDILKKNnEKRAKFVIPnDTIFTVGKYKFEVFYPGKGHAPDNIVVWFNKEKILYGGCFIKSTEA 185 Flavobacterium ...

Feature 1            #                             #                   
1M2X_A       162 KDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEY 215 Elizabethkingia meningoseptica
ELR79471     187 KDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQRTLDLINEY 240 Elizabethkingia anophelis R26
AAF89161     187 KDLGFIGEAYVNDWTQSIHNIQQKFPDVQYVVAGHDDWKDQTSIQHTLDLISEY 240 Elizabethkingia meningoseptica
AAF89160     187 KDLGFIGEAYVNDWTQSIHNIQQKFPDVQYVVAGHDDWKDQTSIQHTLDLISEY 240 Elizabethkingia meningoseptica
AAF89159     188 KDLGYIGEAYVNDWTQSIHNIQQKFPDVQYVVAGHDDWKDQTSIQHTLDLISDY 241 Elizabethkingia meningoseptica
Q9XBN7       188 KDLGFLGEAYVNDWTQSVHNIQKKFPNVQYVVAGHDDWKDQTAIQHTLDLISEY 241 Elizabethkingia meningoseptica
WP_012025466 186 LDLGYLGDADVKEWQKSIKKVQAKFKKPDYIISGHDDWTSKESLNHTLKLVDEY 239 Flavobacterium johnsoniae
AJP77076     183 NDLGYIGESDLAAWPKSIEKLKQKYPDTKIVITGHAAWGNRESLDHTLKLLREK 236 Pedobacter sp. Stok-3
ETZ21715     185 KDLGNTEEANLSQWALTINKIKQKFPNPKFVITGHQNWDHVDALDHTLNLLTNS 238 Pedobacter sp. V48
KIF31492     185 KTLGYLGDANTAAYATTLQNVQQKCQNAQHIIVAHSDWTNLNSLKHSIKLAKRL 238 Hassallia byssoidea VB512170
KIO51907     186 KDLGYLGDADVKEWEKSIKKVQSKFKSPKYIITGHDNYKDLNSLKHTLKLVKEY 239 Flavobacterium hibernum

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