3Q6V,3SD9


Conserved Protein Domain Family
Sfh-1-like_MBL-B2
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cd16305: Sfh-1-like_MBL-B2 
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Serratia fonticola Sfh-I and related metallo-beta-lactamases, subclass B2; MBL-fold metallo-hydrolase domain
MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. B2 MBLs have a narrow substrate profile relative to subclass B1 MBLs that includes carbapenems, and they are active with one zinc ion bound in the Asp-Cys-His site, binding of a second zinc ion in the modified 3H site (Asn-His-His) inhibits catalysis.
Links
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Statistics
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PSSM-Id: 293863
Aligned: 4 rows
Threshold Bit Score: 487.967
Created: 21-Aug-2015
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on related Aeromonas hydrophila CphA and on Serratia fonticola Sfh-I with glycerin bound in the active site
  • Structure:3Q6V: Serratia fonticola Sfh-I binds glycerin and a zinc ion
  • Comment:binding of a second zinc ion in the modified 3H site (Asn-His-His) inhibits catalysis
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #                   #                             ##          
3Q6V_A         6 LTLTHFKGPLYIVEDKEYVQENSMVYIGtdGITIIGATWtPETAETLYKEIRKVspLPINEVINTNYHTDRAGGNAYWKT 85  Serratia fonticola
3SD9_A         6 LTLTHFKGPLYIVEDKEYVQENSMVYIGtdGITIIGATWtPETAETLYKEIRKVspLPINEVINTNYHTDRAGGNAYWKT 85  Serratia fonticola
WP_038635452  25 ITLTHFKGPLYIVEDKAYVQENSMVYIGadDITIIGATWtPETAEALEKEIRKVsaLPIKEVINTNYHTDRAGGNAHWKK 104 Pseudomonas chl...
KMT52978      23 LTLTNFKGPLYIVEDKEYVQENSMVYIGeqHITVIGATWtPATAEKLEQEIRKVspLPIKEVINTNYHTDRAGGNAYWRE 102 Pseudomonas sp....

Feature 1                             #  ##                                      #               
3Q6V_A        86 LGAKIVATQMTYDLQKSQWGSIVNFTRQGnnkYPNLEKSLPDTVFPgDFNLQngSIRAMYLGEAHTKDGIFVYFPAERVL 165 Serratia fonticola
3SD9_A        86 LGAKIVATQMTYDLQKSQWGSIVNFTRQGnnkYPNLEKSLPDTVFPgDFNLQngSIRAMYLGEAHTKDGIFVYFPAERVL 165 Serratia fonticola
WP_038635452 105 LGASIVSTQMTYDLEKSQWKSIVDFTRQGfdkYPRLKESLPDKVYSgDFELQsgRVRALYLGPAHTEDGIFVYFPSERVL 184 Pseudomonas chl...
KMT52978     103 LGASIVSTQLTYDLEKSQWRSIVDFTRQGmehYPVLEQSLPDQVYPgDFALQngHVRALYLGASHTEDGIFVYFPEERVL 182 Pseudomonas sp....

Feature 1           #  #   ##  #                              #                    
3Q6V_A       166 YGNCILKENLGNMSFANRTEYPKTLEKLKGLieqgelkVDSIIAGHDtPIHDVGLIDHYLTLLEKA 231 Serratia fonticola
3SD9_A       166 YGNCILKENLGNMSFANRTEYPKTLEKLKGLieqgelkVDSIIAGHDtPIHDVGLIDHYLTLLEKA 231 Serratia fonticola
WP_038635452 185 YGNCILKEKLGNLSFANRTEYPKTLKKLKELidqgelqVESIIAGHDtPIHGVELIDHYLALLEDA 250 Pseudomonas chlororaphis
KMT52978     183 YGNCILKEKLGNMTFANRSEYPKTLKKLQGLissgelpVETIIAGHNsPIQSVELIDHYLNLLEHG 248 Pseudomonas sp. KG01

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