1ZNB,1A8T


Conserved Protein Domain Family
CcrA-like_MBL-B1
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cd16302: CcrA-like_MBL-B1 
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Bacteroides fragilis CcrA and related metallo-beta-lactamases, subclass B1; MBL-fold metallo-hydrolase domain
MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of MBLs belongs to the B1 subclass. B1 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile.
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Statistics
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PSSM-Id: 293860
Aligned: 21 rows
Threshold Bit Score: 326.124
Created: 15-May-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1A8T: Bacteroides fragilis CcrA metallo-beta-lactamase binds the biphenyl tetrazole class inhibitor L-159061 and two zinc ions
  • Citation:PMID 9545432
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #  ##                                             # # #    
1ZNB_A     11 ISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINnhQAALLDTPINDAQTETLVNWVADSlhAKVTTFIPNHWHGDCIGG 90  Bacteroides fragilis
1A8T_A     11 ISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINnhQAALLDTPINDAQTEMLVNWVTDSlhAKVTTFIPNHWHGDCIGG 90  Bacteroides fragilis
EFR58421   81 ITVQRLAEGIYLYTAVDEIEGYGPVPSNGVLIVRegEAVLLDTPVGDAQTKTLTDWAAETlrACVTTFVPNHWHSDCMGG 160 Alistipes sp. HGB5
EGW51044   40 LDVVRLSGRVYMHVSRYEMPPFGLVPANGLILVDkgEAFLFDTPWTESQTEVLLDWIENVlhARVTACVPNHWHKDAMGG 119 Desulfovibrio sp. ...
AEE54266   31 LKIQALTPKTLVHVTYLNTNQWGKVPCNGMIYYNkgEAIVFDTPPNDSVSLQLIDWIEAKlkAKVKAIVVNHFHNDCLGG 110 Haliscomenobacter ...
EAZ80536   33 LQVEQISQNTFLHISYLNTDDFGKVACNGMIVINegEALVFDTPANEEASLELINWLEKEqqVTVKGVVATHFHWDCLGG 112 Algoriphagus sp. PR1
AIZ41582   33 LKLIPLSNNAFQHITYLNTNDYGKVACNGLVVIHnnEAIIFDTPTSNAVSTELIRWITEIkkSSIKAVVVNHFHEDCLGG 112 Cellulophaga balti...
EAQ37928   35 LEIIKLSDQDYMHVSYLKDGKDGYIPCNGYIRKEgdEVFVFETPLDDSTSVQLIDFIQNDlnATIKAVMVSHAHIDGAGG 114 Dokdonia donghaens...
AEE20942   35 LEIIKLSEQDYVHVSYLKDSYGGYIPCNGYIRVEgsEAFIFDTPLNDTLSEQLITFVQEDlkATIKGVQVSHSHIDGAGG 114 Krokinobacter sp. ...
AFL96616   72 LKVVQIAPDTFVHTSYLATQQWGKVPCNGMIVRHqrEAMVFDTPTDEASSEALIHWIKNElkAEIKWVVPTHFHDDNLGG 151 Ornithobacterium r...

Feature 1                                                              #                  #  #
1ZNB_A     91 LGYLQKKGVQSYANQMTIDLAKEKg--LPVPEHGFTd-SLTVSldgmPLQCYYLGGGHATDNIVVWLPTENILFGGCMLK 167 Bacteroides fragilis
1A8T_A     91 LGYLQRKGVQSYANQMTIDLAKEKg--LPVPEHGFTd-SLTVSldgmPLQCYYLGGGHATDNIVVWLPTENILFGGCMLK 167 Bacteroides fragilis
EFR58421  161 LGYLKTLGVKSYAHRLTHSIAQREg--KPVPDIGFGd-SLRLDlhgtEIRCYYFGGGHSEDNIAVWIPSAKLLFAGCMVK 237 Alistipes sp. HGB5
EGW51044  120 LPAVRRRGIPTYAYDGTIAIARQKg--LCLPEHGFAs-ERTLKlhglEVRNVYLGGGHSTDGIFVWIPAENLLFPGCMAK 196 Desulfovibrio sp. ...
AEE54266  111 LNAFHQRGIPSYANQLTIDLAKANg--YAVPQNGFNg-VLNLKiggeVVENRFLGEGHSKDNIVSYVPSEQVLFGGCMVK 187 Haliscomenobacter ...
EAZ80536  113 LDEFHRKGIHSYASAKTIALAKSVg--YPVPEIDFKk-KLILEagsiKIVNQFFGEGHTKDNFISYVPADQVIFGGCMIK 189 Algoriphagus sp. PR1
AIZ41582  113 LTAFHDIDIPSYGNTQTLALSKEKn--LVTPNYGFDs-EITLKvgelEVMNRHFGEAHTADNIVSYIPSEALLFGGCMVK 189 Cellulophaga balti...
EAQ37928  115 VKAFNEAGIPTYGSSKAAALLARDt--ITLSNTFQL--KDSLMlgktLIKMDYLGPAHTDDNAIAYLEGPEILLGGCMIK 190 Dokdonia donghaens...
AEE20942  115 INAFAKAKIPTYASAKTAALLAKDslaISNPFSQKD--SIQIAe--nFIVMEYLGPAHSDDNSIAYIPASDILLGGCMIK 190 Krokinobacter sp. ...
AFL96616  152 LPAFHRDKIMSIAYYRTQNLSKKHr--KPQTITTFSatDSTWNlggaKIQIGYYGKGHTEDNIVVYFPKDQVLFGGCLVK 229 Ornithobacterium r...

Feature 1     #  #   ##                             ###               
1ZNB_A    168 DnqATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVN 223 Bacteroides fragilis
1A8T_A    168 DnqTTSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGNYGGTELIEHTKQIVN 223 Bacteroides fragilis
EFR58421  238 EmaAQNAGNLSDAVPAAWPATLDSLLVRFPDARIVVPGHGAPGGPELIRHTKALLS 293 Alistipes sp. HGB5
EGW51044  197 DakTVNLGNTEDADVRAWPGTMEKALAAFPDARIVVPGHGQPGGPELLRHTRDLAL 252 Desulfovibrio sp. 6_1_46AFAA
AEE54266  188 Es-NAGKGHLADANLGDWPKTVAKVKAQYPDARFVIPGHGKCGGKELLDYTMELFK 242 Haliscomenobacter hydrossis DSM 1100
EAZ80536  190 Ai-GAGKGNLEDANLSEWSATVEKVKSAFPDTQIVIPGHGKIGGTELLDYTAEMFE 244 Algoriphagus sp. PR1
AIZ41582  190 Sl-NATKGYTGDANLEEWSNTIQKIKEEYPDLKLVIPGHGDAGGQELLDYTIELFK 244 Cellulophaga baltica 18
EAQ37928  191 Sl-EAGKGNLADANLKEWAKTVATAKYLYPDVKQVIPGHGMRGDSTLLTYTIKMFQ 245 Dokdonia donghaensis MED134
AEE20942  191 Pl-DGTKGNLADANLDEWANTVTTLQNRYPNVLQVIPGHGGRGDKELLDYTIGMFQ 245 Krokinobacter sp. 4H-3-7-5
AFL96616  230 El-GAGKGNLSDAFPKEWSATIQKVKHAYPEAKIVVPGHGKIGDKALLDYTAQLFK 284 Ornithobacterium rhinotracheale DSM 15997

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