3IE0,3AF6,2XR1,2YCB,3IEK,3IE1,3IDZ,2DKF,3A4Y,3IE2


Conserved Protein Domain Family
TTHA0252-CPSF-like_MBL-fold
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cd16295: TTHA0252-CPSF-like_MBL-fold 
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Thermus thermophilus TTHA0252 and related cleavage and polyadenylation specificity factors; MBL-fold metallo-hydrolase domain
Includes the archaeal cleavage and polyadenylation specificity factors (CPSFs) such as Methanothermobacter thermautotrophicus MTH1203, and Pyrococcus horikoshii PH1404. In addition to the MBL-fold metallo-hydrolase nuclease and the beta-CASP domains, members of this subgroup contain two contiguous KH domains. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293853
Aligned: 306 rows
Threshold Bit Score: 161.088
Created: 27-Jul-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site of CPSF3 is located at the interface of the MBL-fold metallo-hydrolase and beta-CASP domains
  • Structure:3AF6: Pyrococcus horikoshii CPSF Ph1404 binds two zinc ions and a sulfate
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                           # # ##     
3IE0_A       3 IVPFGAAREVTGSAHLLLaggRRVLLDCGMFqgkee---------arnhAPFGFd----pKEVDAVLLTHAHLDHVGRLP 69   Thermus thermoph...
3AF6_A     191 ITGLGGFREVGRSALLVQtdeSFVLVDFGVNvamlndpykafphfdapeFQYVLr----eGLLDAIIITHAHLDHCGMLP 266  Pyrococcus horik...
EFO81992     3 IQFLGGASAVGATCQVVHtgeRRVLVDAGVRmdgad---------rlpdLAALAg-----VSLDAIIITHAHADHIGALP 68   Oscillochloris t...
AGF55381     6 IDFLGGALEVGGSSILIKinnKNILFDAGIRqna------------skdSMPNFrdiqtyGGLDAIIISHAHLDHIGCLP 73   Clostridium sacc...
ABP66628     3 IVFLGGAKEVGASCVLIKaggKNILLDSGIRmked----------klpnLQLLRe----lGGADVCLISHAHLDHIGSLP 68   Caldicellulosiru...
AFZ15096   312 VTPLGAARSIGASCFRVLigpYEIVLDAGTRpkg------------snpLPAFEh----lKNPNLILITHAHQDHIGALP 375  Crinalium epipsa...
EOS36826     3 FIFLGGAMEIGASSIYVKaggKRFLLDSGIRqsgtk--------dplpdFRTIQe----qGGLDAVIVSHAHMDHIGTLP 70   Lachnospiraceae ...
ADD03475     3 AIFSGGANEVGASCYLINldgKNILLDCGIRmsstk--------dnlpdFRLIQe----hGGVDAVIVSHAHLDHTGALP 70   Thermoanaerobact...
ETW96207     9 LSFLGGASAIGASSALLQvadTSILIDCGVRpkt-------------gnALPDLnql-tgKRLDAIVVTHAHSDHTGALP 74   Candidatus Entot...
ADG05559     2 RVTFLGGTDIGASCLWFEtqtGGWLVDAGVRmddrd--------plpslDRLARa----gDRIQGIFVTHAHQDHIGALP 69   Kyrpidia tusciae...

Feature 1                                                                                      
3IE0_A      70 KLFre-gYRGPVYATraTVLLMEIVLEDALKvmd--------epfFGPEDVEEALGHLRPLEYGEWLRLg---aLSLAFG 137  Thermus thermoph...
3AF6_A     267 YLFrynlFDGPIYTTppTRDLMVLLQKDFIEiqqsn----gqdplYRPRDIKEVIKHTITLDYGEVRDIsp--dIRLTLH 340  Pyrococcus horik...
EFO81992    69 LVAdr-fPATPIYASpaTIRLMEVMLGDAVRvmarraaeelelplYDAALVAETLRRLRPLQAGAQSLPel-pgVIVSAQ 146  Oscillochloris t...
AGF55381    74 IISke-yPNAKIYMNnmTKDLVKVLLYDSLKimsnre---aeiplYAEVDVENTLNRIFTINYEVKFPIfe--dMHVTFY 147  Clostridium sacc...
ABP66628    69 LIAre-yPHIFFYTNqpTKDLIKVLLYDSLKimdake---deipiYAEKNVEDLLDRTITYGFNYTFEPle--gIKVTFF 142  Caldicellulosiru...
AFZ15096   376 VFHqr-fPATPMICTagTREIAHVMLTDCLKvqqsne---dfeqlFDEIDLDQTLFQLQTQPVGKDFEPlp--gLKVRFI 449  Crinalium epipsa...
EOS36826    71 IISka-yPNARIYMTvmTAELTRVLLYDSLKimahre---deiphYTEQDVLDMLGRVTPMRYQAELSIle--dVRLTLY 144  Lachnospiraceae ...
ADD03475    71 IISrm-yPQAKIYMThaTKDLTRVLLYDSLKimere----seipiYAENHVKDMLDRVLCYTPGYTFTPfpdsqIKVTLY 145  Thermoanaerobact...
ETW96207    75 VVHea-yPEAPIYLTppTQDLVSILQRDALKlmdre----gdvplYSERQVESMIERFRPVHHGERFQVg---eIEIVYL 146  Candidatus Entot...
ADG05559    70 LISsl-fPDAPVFMTraTLDLARVMLADALKvsree----gkvsvFTEDQLNDLWPRVRVMGQDKVFGWn---gMQVATY 141  Kyrpidia tusciae...

Feature 1         #                      #                           
3IE0_A     138 QAGHLPGSAFVVAQge--gRTLVYSGDLGNREKDVl-pDPSLPPL-ADLVLAEG 187  Thermus thermophilus HB8
3AF6_A     341 NAGHILGSAIVHLHignglHNIAITGDFKFIPTRLl-ePANAKFPrLETLVMES 393  Pyrococcus horikoshii OT3
EFO81992   147 RAGHIAGAVSVGFEas--dGRLVISGDVSATPQCTilgAALPAPRrPDLMVLES 198  Oscillochloris trichoides DG-6
AGF55381   148 NAGHIAGASCVYLQsp--eGAVFYSGDFSVFSQRTv-eGAKLPKLrPDVAIVES 198  Clostridium saccharoperbutylacetonicum N1-...
ABP66628   143 PAGHILGASMIFIQtq--eGSVLYTGDFSTDKQLTvdkASIPKIR-PDVVICES 193  Caldicellulosiruptor saccharolyticus DSM 8903
AFZ15096   450 HAGHIVGAACVYIRyg--eRSLLYTGDYNTTNSRTtdgLRLADLPqADILITES 501  Crinalium epipsammum PCC 9333
EOS36826   145 PAGHIAGAACACLAte--eGTLFYSGDFAAFSQRTiegIHVPKLR-PDVAIVET 195  Lachnospiraceae bacterium A4
ADD03475   146 PAGHILGAASVYITsa--eGSIFYSGDFSGFRQNTiegAFIPKLR-PDVAIFES 196  Thermoanaerobacter italicus Ab9
ETW96207   147 PASHILGASMVYFStp--aGNVMFTGDYSVDAQRTv-pALDRPTLpVDLLVTET 197  Candidatus Entotheonella sp. TSY1
ADG05559   142 SAGHILGAVSIGFVte-aeGSVLVTGDFSVTPGRLlpgLRMPRGSaYDAVITES 194  Kyrpidia tusciae DSM 2912

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