Conserved Protein Domain Family
Int9-like_MBL-fold
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cd16294: Int9-like_MBL-fold 
integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1-Int14 (Integrator subunits). This subgroup includes Int9, also known as protein related to CPSF subunits of 74 kDa (RC-74). Integrator complex has been implicated in a variety of Pol II transcription events including 3' end processing of snRNA, transcription initiation, promoter-proximal pausing, termination of protein-coding transcripts, and in HVS pre-miRNA 3' end processing. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293852
Aligned: 8 rows
Threshold Bit Score: 263.972
Created: 30-Apr-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative RNA
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on Pyrococcus horikoshii CPSF Ph1404 and human CPSF3 (CPSF-73) the active site is located at the interface of the MBL-fold metallo-hydrolase and beta-CASP domains
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                      
Q9NV88      1 MKLYCLSGHPTLPCNVLKFKStTIMLDCGLDmtstlnflplplvqsprlsnlpgwsl-------kdgnafldkelkecsg 73  human
Q5ZKK2      1 MKLYCLSGHPTLPCNVLKFKStTIMLDCGLDmtstlnflplplvqsprlsklpglvl-------kdgstfldkelkecsg 73  chicken
Q6DFF4      1 MKLYCLSGHPTLPCNILKFKSsTIMLDCGLDmtstlsflplplvhstrlsklpgwvt-------kdgnnqfekelkecsg 73  African clawed frog
A7SBF0      1 MKLYCVGHSVSSPCLVLQFKQtNIMLDCGLDmstvnqftplslvnnekfsqlkswssre---lqeiegftaqnnlkeagg 77  starlet sea anemone
AAI24794    1 MKLYCLSGHPTLPCNVLKFKStTIMLDCGLDttaalyflplplvhsprlsklpgwvs-------kdgainlekelkecsg 73  zebrafish
KDR16196   27 MKLYCLSSDPNRPCYVLRFKEiTLMLDCGLAtqtvlnflplplvpstrlnnlpgwmpr------disdpqlegelkeccg 100 Zootermopsis nevad...
EPB74664    1 MQLTSLSWHAHKPCILIRFQSaTILVDCAVDfssynlflpyvydersrlknlplp------------ygddlpylkqlnd 68  Ancylostoma ceylan...
EEN45325    1 MKLYCLSGHPNLPCLVLKFKSvTVMLDCALDltttfrflplplvhsarlaklpswvpkdadagdqdtlktlkkelkecag 80  Florida lancelet

Feature 1                                  # # ##                                             
Q9NV88     74 hvfvdsvpefCLPETELIDLSTVDVILISNYHCMMALPYITEHtg--ftGTVYATepTVQIGRLLMEELVNfiervpkaq 151 human
Q5ZKK2     74 hvfvdsvpefCLPETELLDLSTVDVILISNYHCMMALPYITEYtg--ftGTVYATepTVQIGRLLMEELVNsiervpkaq 151 chicken
Q6DFF4     74 rvfvdsvpefCLPETELIDLSTVDVILISNYHCMMALPYITERtg--ftGTVYATepTVQIGRLLMEELVNfiervpkaq 151 African clawed frog
A7SBF0     78 rlfidaepevCPPETGLIDFSMVDVILISNYHHMLALPFITEYsg--fnGKIYATepTIQIGRDLMLELVTfaervpkrr 155 starlet sea anemone
AAI24794   74 rvfvdsqpefCLPEKELLDLSTIDVILISNYHCMMALPYITEHtg--ftGTVYATepTLQIGRLLMEELVAfmervpkah 151 zebrafish
KDR16196  101 rvfvdsapefFPPQPKIIDFSEVDVILISNYLCMLALPFITEGtg--faGVVYATepTLQIGRLFLEELVQhieqtpkat 178 Zootermopsis nevad...
EPB74664   69 nvfvdgvpevHPVPLEAVCMNTVDYILVSNWHSLVALPFYTENsg--fkGVVYSTepVVQFGRLMMLELIDyhdrivfdd 146 Ancylostoma ceylan...
EEN45325   81 rvfvdsppevGIPEDGLLDLSTVDVILVSSFQCILALPYITEYtgfngtGMIYATepTAQMGRQLMEELVQhtervpktc 160 Florida lancelet

Feature 1                                                                       #             
Q9NV88    152 saslwknkdiqrllpsplkdavevstwrrcytmqevnsALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHy 231 human
Q5ZKK2    152 sastwknkevqrllpaplkdavevsmwrkcytmpevnaALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHy 231 chicken
Q6DFF4    152 satvwkhkdvqrllpaplkdavevftwkkcysmqevnaALSKIQLVGYSQKIELFGVVQVTPLSSGYALGSSNWVIQSHy 231 African clawed frog
A7SBF0    156 ngnmwkndnvirclpaplnelanvkswrvlyskhdvkaCISKIQAVSYSEKLDLCGILQLSAHSSGFCLGSSNWMLESEy 235 starlet sea anemone
AAI24794  152 aascwknkeiqrllpgplkdavevwswskcyslqevnsALSKVQLVGYSQKVELFGAVQVTPLSSGYSLGSSNWIIQSHy 231 zebrafish
KDR16196  179 lashwkehlhvlpp--plcdsqkprswkhiynmravnsSLARIQMVGYNEKLDVYGAVGVMAVSSGYCLGSSNWVISSHy 256 Zootermopsis nevad...
EPB74664  147 dgkk---------------------wkdpsvywqtmeeALSRITTVSFNQPVYLEGNVVVTACPSGYSIGSANWVFKTEy 205 Ancylostoma ceylan...
EEN45325  161 taskwkepgvfkmlpaqlrdglnpaslrdcyglhdvnsALSKVQLVGYAQKLDVFGALQIMPLSSGYCIGSCNWLIQSHy 240 Florida lancelet

Feature 1            #                          
Q9NV88    232 EKVSYVSGSSLLTTHPQpMDQASLKnSDVLVLTG 265 human
Q5ZKK2    232 EKVSYVSGSSLLTTHPQpMDQASLKnSDVLILTG 265 chicken
Q6DFF4    232 EKVSYVSGSSLLTTHPQpMDQTSLKnSDVLILTG 265 African clawed frog
A7SBF0    236 EKISYLSPSSSFTTHPLpLNQTVLKnSDVLIITG 269 starlet sea anemone
AAI24794  232 EKVSYVSGSSLLTTHPQpMEQSSLKnSDVLILTG 265 zebrafish
KDR16196  257 EKITYVSGSSTLTTHPRpMDQTALKnANVLILTG 290 Zootermopsis nevadensis
EPB74664  206 ERIGYLASSSVRSTHSRsIEWEKLHdADALILTS 239 Ancylostoma ceylanicum
EEN45325  241 EKISYISSSSVLTTHPQpMDQGPLQnTDVLILAG 274 Florida lancelet

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