2I7X


Conserved Protein Domain Family
CPSF2-like_MBL-fold
?
cd16293: CPSF2-like_MBL-fold 
Click on image for an interactive view with Cn3D
cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
CPSF2, also known as cleavage and polyadenylation specificity factor 100 kDa subunit (CPSF-100), is a component of the CPSF complex, which plays a role in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and during processing of metazoan histone pre-mRNAs. This subgroup includes Ydh1p, the yeast homolog of CPSF2. In addition to this MBL-fold metallo-hydrolase domain, members of this subgroup contain a beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domain. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
?
Statistics
?
PSSM-Id: 293851
Aligned: 72 rows
Threshold Bit Score: 218.929
Created: 23-Feb-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on Pyrococcus horikoshii CPSF Ph1404 and human CPSF3 (CPSF-73) the active site is located at the interface of the MBL-fold metallo-hydrolase and beta-CASP domains
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                     #
2I7X_A      3 YKYNCCDDGSGTTVGSVVRfDNVTLLIDPGWNpskvs--------------yeqciKYWEKv-------iPEIDVIILSQ 61   baker's yeast
GAO47354    2 FLFTPLANSTQQSAQLVEI-DDVRILIDCGWTesm-------------------pfEQMEQila----naPKIDAILLSH 57   Saitoella complic...
CCG81055    1 MIEFTTLNELSGAGSLLSF-DSTLVLIDPACD------------------------KLLRFdae---sipRKPDLIILSH 52   Taphrina deforman...
O74740      2 LNYQCLETDSYCGTSHIEL-DGIHIYIDPGSD------------------------DSLKHpe-----vpEQPDLILLSH 51   Schizosaccharomyc...
CCU98738   16 GGASTSTECSKALAYLVEI-DQARILLDCGAPedftfppslvktdgadrglhgslpEILQRi-------gPTIDVVLLFH 87   Malassezia sympod...
EPZ32528    7 FTPISGAFGDEPLCYLLEI-DQQKILLDCGCDpafe-----------------vlpDLLSRitk----ltKTIDVILLSH 64   Rozella allomycis...
EIW61467    7 LSGAAGTVRTVPLAYLLQV-DDVRILLDCGSPdwcpepsseeg---ddvlswtkycDALKEc-------aPSVDLVLLSH 75   Trametes versicol...
KIJ56611    7 LAGGAQSSQITPLCYLLQV-DDVRILLDCGSPdwnpesftk-------ksddeaaeEPWEQyvqalesiaYTVDLVLLSH 78   Sphaerobolus stel...
EOR03512   13 RATSGEMKTSEPLCYLMEM-DGARILLDCGSRdweanan-----------pefgyeRALKDi-------aPTVDLVLISH 73   Wallemia ichthyop...
KLT40851    8 SSSASSSSTSEPVAYFLEL-DDARILLDMGQRdyrasle----------qdnweyeDKIKEl-------aPTLSLVLLSH 69   Trichosporon olea...

Feature 1      # ##                                                                           
2I7X_A     62 PTIECLGAHSLLYynf----tsHFISRIQVYATLPVINLGRVSTIDSYASagvigpyd---------------------- 115  baker's yeast
GAO47354   58 ASVKHLGAYPYLFshlqknlatPTASLPPVYATLPVTAIGRTSSHETYASsslsp------------------------- 112  Saitoella complic...
CCG81055   53 ADLTHLGGYVYGFk-------hLDWHNVPVYASLPVVNMGRTTMYDALKStltey------------------------- 100  Taphrina deforman...
O74740     52 SDLAHIGGLVYAYy-------kYDWKNAYIYATLPTINMGRMTMLDAIKSnyisd------------------------- 99   Schizosaccharomyc...
CCU98738   88 AELSHMGLYAYAYt--------HFGLQCPVYATLPVQTMGRLQMLEVVRSwqaeadvrsss------------------- 140  Malassezia sympod...
EPZ32528   65 SNLEYLGGLVYVYk--------EMALHCPIYATIPIMNFGPLTIQEALRAkcldgpf----------------------- 113  Rozella allomycis...
EIW61467   76 GDLSHSGLYPYAYs--------HWGLTAPAYTTLPIQAMAKTAATEDVEAirdeqpvediappseeslapegsvspspnn 147  Trametes versicol...
KIJ56611   79 GDLAHSGLIPYAYa--------NWNLRAPSYCTLPVQAMARMAVLDQVESvrseedvdesheddihsev----------- 139  Sphaerobolus stel...
EOR03512   74 ASTKHSGLYAYAYt--------HYGLTCPAYCSLPVKELARLTTLEDIIGwrsereitgekasesp-------------- 131  Wallemia ichthyop...
KLT40851   70 SPSTYLGLYPYARa--------HWGLTCPVYATQPTVEMGRVVCLSEAESwrsecpvevadgeedtai------------ 129  Trichosporon olea...

Feature 1                                                                  #                  
2I7X_A    116 -------------------tnkldleDIEISFDHIVPLKYSQLVDLrsryDGLTLLAYNAGVCPGGSIWCISTYS-EKLV 175  baker's yeast
GAO47354  113 ---------------------pfppnVIDAAFDHIQSLRFSQPTRIm---GGVSITAFNAGHTLGGTIWKLERGG-ETVV 167  Saitoella complic...
CCG81055  101 ----------------------iamaDIDDAFDWVTSLRYSQATQLsgkcQGITITAYNAGHTLGGALWKITRGS-DHIV 157  Taphrina deforman...
O74740    100 ----------------------mskaDVDAVFDSIIPLRYQQPTLLlgkcSGLTITAYNAGHTLGGTLWSLIKES-ESVL 156  Schizosaccharomyc...
CCU98738  141 ----------------pvqrflpteaQVDEAFDAIRTLRYMQPTPLdgkcAGLVLTAYNAGHSLGGTVWKLRSPSvGTVV 204  Malassezia sympod...
EPZ32528  114 --------------------syfsmgDIMPVFEKCIGLRYLQNITLpgivRGIHAVPYNAGHSLGACIWRLRKDT-DDIV 172  Rozella allomycis...
EIW61467  148 atppassptpspssravkhryvatvqQVHDAFDSVNVLRYSQPCHLqgkcQGLTIIPFNAGHTLGGTIWKIRSPSaGTIL 227  Trametes versicol...
KIJ56611  140 -------rdgetqkrnkagkyiptikQVHEAFDSFTALRYSQPTHLqgkcQGLTIIPYSAGHTLGGTIWKIRSPSsGTIL 212  Sphaerobolus stel...
EOR03512  132 ----------datdqshsplfvptreENRSAWSAVKDVRYHQPQHLygklRGVTITAYSSGHTLGGTLWKIRAPSvGTIL 201  Wallemia ichthyop...
KLT40851  130 ---------iakgsnpprgryvptveEIHEAFNHVKAIRYNQPLHLggdlSHLLVTPFPSGHVLGGTLFKIRSPTsGTVL 200  Trichosporon olea...

Feature 1        #                                        
2I7X_A    176 YAKRWNHTRDNILnAASILDAtgkpl---stlmRPSAIITTLDR 216  baker's yeast
GAO47354  168 VAGDWNHARERVFaSSVLFNEgqvl----gelrKPGALVLGVGK 207  Saitoella complicata NRRL Y-17804
CCG81055  158 YAVDWNQARDQHLnGTALFSGgqvq----etlaRPSLLITDSKN 197  Taphrina deformans PYCC 5710
O74740    157 YAVDWNHSKDKHLnGAALYSNghil----ealnRPNTLITDANN 196  Schizosaccharomyces pombe 972h-
CCU98738  205 MALDWNHHRERHLdGTALLSVgaaapl-ahaigQPDILITDMER 247  Malassezia sympodialis ATCC 42132
EPZ32528  173 YAVGYNHRKEKYVnEASLDAIs-----------RPTLLITDSKH 205  Rozella allomycis CSF55
EIW61467  228 YAVDMNHMRERHLdGTVLIRQgstggv-feslaRPDLLITDAER 270  Trametes versicolor FP-101664 SS1
KIJ56611  213 YAVDLNHMRERHLdGTVILRHtsgdigifeplaRPDLLITDAER 256  Sphaerobolus stellatus SS14
EOR03512  202 YAVGLNHMKERHLdGTALIRGdqgglsvheqlvRPGLVITDSER 245  Wallemia ichthyophaga EXF-994
KLT40851  201 YAVGMNHTGERHIdGMVTGQGgltgy--aedirRPDLLIVEGDR 242  Trichosporon oleaginosus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap