2I7T


Conserved Protein Domain Family
CPSF3-like_MBL-fold
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cd16292: CPSF3-like_MBL-fold 
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cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
CPSF3 (also known as cleavage and polyadenylation specificity factor 73 kDa subunit/CPSF-73) functions as a 3' endonuclease in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and in 3' end processing of metazoan histone pre-mRNAs. This subgroup also contains the yeast homolog of CPSF-73, Ysh1/Brr5 which has roles in mRNA and snoRNA synthesis. In addition to this MBL-fold metallo-hydrolase domain, members of this subgroup contain a beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domain, and a RMMBL domain (RNA-metabolizing metallo-beta-lactamase). Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293850
Aligned: 37 rows
Threshold Bit Score: 327.62
Created: 23-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site of CPSF3 is located at the interface of the MBL-fold metallo-hydrolase and beta-CASP domains
  • Structure:2I7T: human CPSF3 binds two zinc ions and a sulfate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 # # ##               
2I7T_A      12 LLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLqktSFKG 91   human
O13794      19 LEFINLGAGNEVGRSCHVIQYKGKTVMLDAGVHPAYTGLSALPFFDEFDLSTVDVLLISHFHLDHVASLPYVMqktNFRG 98   Schizosaccharomy...
Q8WZS6      24 LMFLNLGGGNEVGRSCHIIQYKGKTVMLDAGQHPAYDGLAALPFFDDFDLSTVDVLLISHFHIDHAASLPYVLaktNFRG 103  Neurospora crass...
EMR11460    20 FEFTNLGAGNEVGRSCHIIQFRGKTIMLDAGVHPAYNGLSALPFYDEIDLSTVDILLISHFHVDHIASLPYVItktNFKG 99   Pneumocystis mur...
KIZ07536    28 VKITPLGAGQEVGRSCIIVEYMGKRVMLDCGIHPGYSGLGSLPFLDEVELDQIDVALITHFHLDHCAAVPYLIgktNFKG 107  Monoraphidium ne...
CEF99060    16 LEIIPLGAGSEVGRSCVVATFRGKTLMFDCGIHPGFSGIASLPYLDDVDLSAVDALLVTHFHLDHCAAVPFLVgrtDFRG 95   Ostreococcus tauri
KFG45168   110 VEITPLGAGCEVGRSCVIARYKGLTVMFDCGVHPAYSGLGALPIFDAVDMTSVDVCLVTHFHLDHCGALPYLVtktAFRG 189  Toxoplasma gondi...
EZG63628     5 LEVVPLGAGCEVGRSCIKVSYHGKTILLDCGIHPAHSGLPALPVFDGVDLSKVDLCLVTHFHLDHCGVVPYLLqhtWFRG 84   Gregarina niphan...
EFN58363    25 VQILPLGAGQEVGRSCIIVRYCGKTVMLDCGVHPGFFGIASLPFFDEVDLSEVDAMLVTHFHLDHCAAVPYVTghtSFRG 104  Chlorella variab...
EFJ51016    24 AHIIPLGAGSEVGRSCIILKYQDKTVMFDCGIHPAFKGMDSLPLLDDIDIATVDVALITHFHLDHCAAVPYLLrktRFKG 103  Volvox carteri f...

Feature 1                                                                                      
2I7T_A      92 RTFMTHATKAIYRWLLSDYVKvsnisa-----------------------ddmlyTETDLEESMDKIETINFHEVKEVAG 148  human
O13794      99 RVFMTHPTKAVCKWLLSDYVKvsnvgm-----------------------edqlyDEKDLLAAFDRIEAVDYHSTIEVEG 155  Schizosaccharomy...
Q8WZS6     104 RVFMTHATKAIYKWLIQDSVRvgntssn--------------------pqsslvyTEEDHLKTFPMIEAIDYNTTHTISS 163  Neurospora crass...
EMR11460   100 RVFMTHPTKAIYKWLLTDFLRvsntts-----------------------eehlyEEKDLIKSFEKIEVVDYHSTIDVNG 156  Pneumocystis mur...
KIZ07536   108 RLIMTHPTKAIFYTLLQDFVRvsagsa-----------------------dealySEADLDAAMARAEVLDFDQTIDIDG 164  Monoraphidium ne...
CEF99060    96 RIFMTHPTKAIYHMLMQDFVRlmkqgg----------------------geeplfTDADLEASMKRIEVVDFHQEIDVDG 153  Ostreococcus tauri
KFG45168   190 RVFMTEPTRVISKLVWLDYARmsafsqgsrdnqgaaaaqaaagsqaekaggaflyDEDDVDATVRMVECLDFHQQVEVGG 269  Toxoplasma gondi...
EZG63628    85 KTIMTEPTKAICHLVWNDFAAfarhts-----------------------ksplyTEQDIRACLPKIDVMHFNQTVVYNG 141  Gregarina niphan...
EFN58363   105 RVLMTHPTKAIVHTLLKDFVKvskggs-----------------------geglySERDLDAAMERTEVIDFHQTVDLDG 161  Chlorella variab...
EFJ51016   104 RIFMTHPTKAIYYSLLRDLAKgakhss-----------------------eealfNEEDLDASMEQIEVVDFYQTIEVSG 160  Volvox carteri f...

Feature 1               #                    #                           
2I7T_A     149 IKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLmAAEIPNIk-PDILIIES 205  human
O13794     156 IKFTPYHAGHVLGACMYFVEMAGVNILFTGDYSREEDRHLhVAEVPPKr-PDVLITES 212  Schizosaccharomyces pombe 972h-
Q8WZS6     164 IRITPYPAGHVLGAAMFLIEIAGLKIFFTGDYSREEDRHLiSAKVPKGvkIDVLITES 221  Neurospora crassa OR74A
EMR11460   157 VKFTPYHAGHVLGAAMFFIEIAGIKILFTGDYSREEDRHLiPAELPPIq-PDILITES 213  Pneumocystis murina B123
KIZ07536   165 IQVTAHRAGHVLGAAMFTVDIGGVRTLYTGDYSRVADRHLpGADTPHLr-PDILIVES 221  Monoraphidium neglectum
CEF99060   154 VKVTPYRAGHVLGACMFNVDIGGLRVLYTGDYSRIADRHLpAADIPAIp-PHVVIVES 210  Ostreococcus tauri
KFG45168   270 IKVSCFGAGHVLGACMFLIEIGGVRMLYTGDFSRERDRHVpIAEVPPVd-VQLLICES 326  Toxoplasma gondii p89
EZG63628   142 IEVTALGAGHVVGACMFLVAIDGVNILYTGDYSAEDERHVpQIYVPPSfsVQVLICEA 199  Gregarina niphandrodes
EFN58363   162 IRVTAYRAGHVLGAAMFMVEVGGMRLLYTGDYSRIPDRHMpAADLPAQr-PHIVVVES 218  Chlorella variabilis
EFJ51016   161 MQITPYRAGHVLGAAMFMVEVAGLRCLYTGDYSRLPDRHLpGADTPPVt-PHIVIVES 217  Volvox carteri f. nagariensis

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