2FHX,4BP0


Conserved Protein Domain Family
SPM-1-like_MBL-B1-B2-like
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cd16286: SPM-1-like_MBL-B1-B2-like 
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Pseudomonas areoginosa SPM-1 and related metallo-beta-lactamases, subclasses B1 and B2 like; MBL-fold metallo-hydrolase domain
SPM-1 was first identified in a Pseudomonas aeruginosa strain from a paediatric leukaemia patient and is a major clinical problem. MBLs (class B of the Ambler beta-lactamase classification) have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs are most closely related to each other. SPM-1 appears to be a hybrid B1/B2 MBL.
Links
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Statistics
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PSSM-Id: 293844
Aligned: 4 rows
Threshold Bit Score: 408.073
Created: 15-May-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:includes second sphere residues which may modulate the substrate preferences and the resistance profile of SPM-1 expressed in P. aeruginosa
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    ##              #                            ## # ##  
2FHX_A           4 VDLPYNLTATKIDsDVFVVTDRDFYSSNVLVAKMLdgTVVIVSSPFeNLGTQTLMDWVAKTmkPKKVVAINTHFHLDGTG 83  Pseudomonas a...
4BP0_A           8 VDLPYNLTATKIDsDVFVVTDRDFYSSNVLVAKMLdgTVVIVSSPFeNLGTQTLMDWVAKTmkPKKVVAINTHFHLDGTG 87  Pseudomonas a...
EYF06851        61 VKLAEDLVLRELGpGVHLITHAHPWAANALLVEMAngDLVLCDPTYtVDAMRRVLAWIDGHhgKRRIVAISTHFHIDRVG 140 Chondromyces ...
jgi:Spirs_2827  38 IRLNDELEVREILpNAFVITHKFPWGGNSLVVLIGekYAVFVDTPYtPEATENVLDWINKQygNRQFIEINTGYHVDNLG 117 Spirochaeta s...

Feature 1                                                                                          
2FHX_A          84 GNEIYKKmGAETWSSDLTKQLRLEENKKdrikaaefykn---edlkrrilsshPVPADNVFDLkqGKVFSFsnELVEVSF 160 Pseudomonas a...
4BP0_A          88 GNEIYKKmGAETWSSDLTKQLRLEENKKdrikaaefykn---edlkrrilsshPVPADNVFDLkqGKVFSFsnELVEVSF 164 Pseudomonas a...
EYF06851       141 GNGALVErGIPVYGADLTLKMLAERGDAgrrwlresldd---kaliaefeaqpTVAPDHPFPAaeGLTLRFgeEQVVVHY 217 Chondromyces ...
jgi:Spirs_2827 118 GNDALLHrNIPIIGSDKTVSLLRERGEAtrqltmgwlegpgnekflkrhetipYVGPSQIFQLteGYHFTVgdEPIEVFF 197 Spirochaeta s...

Feature 1              #                  #                                    ##                 
2FHX_A         161 PGPAHSPDNVVVYFPKKKLLFGGXMIKp-KELGYLGDANVKAWPDSARRLKKFdaKIVIPGHGEWGGPEMVNKTIKVAE 238 Pseudomonas ae...
4BP0_A         165 PGPAHSPDNVVVYFPKKKLLFGGCMIKp-KELGYLGDANVKAWPDSARRLKKFdaKIVIPGHGEWGGPEMVNKTIKVAE 242 Pseudomonas ae...
EYF06851       218 PGPGHAPDNVVVVFPERGILFGGCLVAagERIGNKSDADMARWGDSVRSLHRFkpRMVIPGHGERLDPGLLDHTLKLLA 296 Chondromyces a...
jgi:Spirs_2827 198 PGETHAPDNIVVYFPERKILFGGCMLRvgNGTGNRADANMDTWKSSVERLRDFdcVAVIPGHGIRFDPGVIENTISVLP 276 Spirochaeta sm...

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