3JXP,1XTO


Conserved Protein Domain Family
PQQB-like_MBL-fold
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cd16274: PQQB-like_MBL-fold 
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Coenzyme pyrroloquinoline quinone (PQQ) synthesis protein B and related proteins; MBL-fold metallo hydrolase domainhydrolase domain
PQQB is essential for the synthesis of the cofactor pyrroloquinoline quinone (PQQ) in Klebsiella pneumonia. PqqB is not directly involved in the PQQ biosynthesis but may serve as a carrier for PQQ when PQQ is released from PqqC. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293832
Aligned: 31 rows
Threshold Bit Score: 284.511
Created: 3-Sep-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeputative metal
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
3JXP_A      3 MYIQVLGSAAGGGFPQWNCNCVNCKGyrdgtlKATARTQSSIALSDDgvHWILCNASPDIRAQLQAFAPMQParalrdTG 82  Pseudomonas putida...
KJY30277    1 MKIRILGTAAGGGLPQWNCGCAGCATar---rTGAARSQDCLAVSADgaAWYLVNASPDLRSQLLATPELAPppgtrdTP 77  Streptomyces sp. N...
KEQ24179    1 MLLKIMGTAAGGGFPQWNCACPNCHLarardgQALTRMQSSVAVSSDgaAWYLINATPDIRQQIELQPSLRPgpglrsTP 80  Paenibacillus sp. ...
KKO51271    1 MIVKLLGTAAGGGFPQWNCACPGCRFarteagQAHSRTQNGAAVSCDgqTWYLINAAPDISAQIEAEPSLQPgpairsSP 80  Paenibacillus sp. ...
B3R8D4      2 TTIRVLGSAAGGGFPQWNCNCRNCDGvrrgtvRATPRTQSSIAVCGDgpEAILVNASPDILQQLRQTPALQParaardTA 81  Cupriavidus taiwan...
ACS22810    1 MKVLVLGSGAGGGFPQWNCNCRLCAGqrqgvlDACARTQSSVAVSADgeSWVLLNASPDIGQQIRSHPQLHPrhglrdTP 80  Variovorax paradox...
EDP46604    1 MRLKILGSAAGGGFPQWNCHCSNCQNvrvksiTTLSRTQSSIAISENskKWILVNASPDIRKQLEDFHEAQQtnrlrdSG 80  Rickettsiella grylli
KIF19462    1 MQIKILGTAAGGGLPQWNCNCPGCQAartsttGVCWLNQSSIAVRANdrPWFLVNASPDVRQQLELLREGKPasi-rsSP 79  Scytonema millei V...
KIQ65077    1 MRLRVLGTAAGGGLPQWNCACPTCARara-agPGAWRTQECLAVGVSddAWYLVNASPDLRVQLLAAPGLTPpdgtrsTP 79  Kitasatospora gris...
AHH94203    1 MKVLVLGTAAGGGFPQWNCACAQCAKvr--agALPARTQDCLAVSGNgqDWWLLNASPDIRGQLVSAPEFTPgpgrrdTP 78  Kutzneria albida D...

Feature 1            # # ##                                                                   
3JXP_A     83 INAIVLLDSQIDHTTGLLSLREg-cPHQVWCTdmVHQDLTTGFPLfnmlshwnGGLQWNRIEl-----EGSFVIDac--p 154 Pseudomonas putida...
KJY30277   78 LRGVLLTSGELDHTLGLVTLREa-aALTVHATapVRAALHEAFPVgpll-apyTKARWHTVVp-----GEPVELAg---- 146 Streptomyces sp. N...
KEQ24179   81 IAGVLLTDAELDHTIGLLSLREg-gQLDIFATgpVMQALAGPFPVrhmlepyaGAHWRAMTP------GVPFALFs---d 150 Paenibacillus sp. ...
KKO51271   81 IAGVMLTDAELDHTIGLLSLREg-gTLNVYVTapVADALTESFPIrpml-epyAASRWHEMTp-----GEPFALFg---g 150 Paenibacillus sp. ...
B3R8D4     82 IAAVLLMDAQIDHVTGLLMLREhrrALPLYATasVLEDLAGAFPLtril-shyCGLQCHALPc----dGMAFSVPpl--d 154 Cupriavidus taiwan...
ACS22810   81 IKAVVLMDAQIDHVAGLLGLREg-pRIDLYATpcVFEDLTTSFPVlgvl-ehyCGTRWHMLAvagtqtRIDFGVAgf--p 156 Variovorax paradox...
EDP46604   81 IWAIILTDSQIDHVAGLLSLREa-eKLIIYCTevVREELTYHLPLfeil-knyCVIECNRIHd-----SHVFTVQgf--e 151 Rickettsiella grylli
KIF19462   80 IAGIVLSDAEIDHTTGLILLREsaqPLRLYGTdtVRRALTEGFPLlstl-egyCGVEWSLLEp-----GRPINLGkggan 153 Scytonema millei V...
KIQ65077   80 LRGVLLTDGELDHTTGLLALREg-aELDVHAPppVWRSLGEVLPLrgl--lacYGASRWHPL------DRPLRLDg---- 146 Kitasatospora gris...
AHH94203   79 LRGVLLTDAELDHTLGLFVLREg-gGQQAFAPrnALDALRADLGLravldryaGWTWTESLP------GKAFDLAg---- 147 Kutzneria albida D...

Feature 1                                        ##                     #                    #
3JXP_A    155 NLKFTPFPLRSAAPPYSpHRFDp------------HPGDNLGLMVEdtrtggKLFYAPGLgqVDEKLLAMMHGADCLLVD 222 Pseudomonas putida...
KJY30277  147 GLVAEPLALGGKRPRYAaDLAAlpagerseepsggRTDWVIGYRFTeadgraRAVYAPGLaaWTPAVDRAVADADVVILD 226 Streptomyces sp. N...
KEQ24179  151 RLEVTPFCLGSKAPRYAyGCLGgde-------gssAPAWVVGYRFEdrltggKVVYAPGVevWSDELEQQLADADCILLD 223 Paenibacillus sp. ...
KKO51271  151 QLTVTPFVLGCKAPRYAyASSRngd-------aasNSAWVIGLRLKdeatggVVIYAPCVeaWTPELDSRLADADCILID 223 Paenibacillus sp. ...
B3R8D4    155 GVALTAVPLQSKAPPYSpRRHAp------------QPGDNIGLRIEdrhsgrSAFYAPGLgqVDDHVFAQLRRADVVLVD 222 Cupriavidus taiwan...
ACS22810  157 SLRFTAVAIPGKAPPYSpHRREq------------TVGDNIALLIEdlqggqRLFYAPGLaeVGPEELRWMHDADCLLLD 224 Variovorax paradox...
EDP46604  152 NLRLTPIDLPGKSPPYSpYRHTp------------KRGANTALMILdtltqkTIFYAPAIaqWDEPLFQRMNNADCVLVD 219 Rickettsiella grylli
KIF19462  154 GLEVEAFPLAAKPPKYMrHKVVa------------DEVWVVGLTFRdstsgkVVTYAPGLaqVDEKILDRLESSDCILVD 221 Scytonema millei V...
KIQ65077  147 GLTVDAFPVSDKRPRYAaHVDA-------------PGPWTVAYRFTdtrtgaCAVYAPSLadWPDGFDAFLAGADCLLLD 213 Kitasatospora gris...
AHH94203  148 GLRAIPVPVGSKRPKYAgQSTV-------------DDTWVLAYRVEdpa-tgGVLVYAPC--LASWPEGLLTGASIAFVD 211 Kutzneria albida D...

Feature 1      
3JXP_A    223 G 223 Pseudomonas putida KT2440
KJY30277  227 G 227 Streptomyces sp. NRRL S-495
KEQ24179  224 G 224 Paenibacillus sp. MSt1
KKO51271  224 G 224 Paenibacillus sp. DMB20
B3R8D4    223 G 223 Cupriavidus taiwanensis
ACS22810  225 G 225 Variovorax paradoxus S110
EDP46604  220 G 220 Rickettsiella grylli
KIF19462  222 G 222 Scytonema millei VB511283
KIQ65077  214 G 214 Kitasatospora griseola
AHH94203  212 G 212 Kutzneria albida DSM 43870

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