3IZQ,3MCA


Conserved Protein Domain Family
HBS1-like_II
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cd16267: HBS1-like_II 
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Domain II of Hbs1-like proteins
S. cerevisiae Hbs1 is closely related to the eukaryotic class II release factor (eRF3). Hbs1, together with Dom34 (pelota), plays an important role in termination and recycling, but in contrast to eRF3/eRF1, Hbs1, together with Dom34 (pelota), functions on mRNA-bound ribosomes in a codon-independent manner and promotes subunit splitting on completely empty ribosomes.
Links
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Statistics
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PSSM-Id: 293912
Aligned: 44 rows
Threshold Bit Score: 91.4208
Created: 6-Aug-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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18S rRNA
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:18S rRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on Homo sapiens 80S ribosome-RF3 complex structure
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ##                                                         # #
3IZQ_1       400 PFLFSVLEIIPSKktsndLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGsqqgqstnhEETDVAIKGDFVTLKLR 479 baker's yeast
KLU86366     597 PLRMTISDVYRTTl---sPLTITGRIDAGSVQTGDAILVQPSGEKAYVKSLEMDs--------EPVDWAVAGQNVSIHLA 665 Magnaporthe poa...
EQL04042     647 AFRMPISEVFRSQq---gTTTLAGRIDSGTVQIGDSVVLQPSGESAYIKSIMVDt--------DGQDWAVAGQNVSIALS 715 Ophiocordyceps ...
ERT01923     643 PLRLPIFDISKAAg---sAVTVTGLIEAGSLQVGDALLALPGNARAYIKSILRNg--------QAAEWAVAGQNVALDLT 711 Sporothrix sche...
XP_002841365 160 PLRITISDVFRGGiq--nPVSISGRIEAGGLQIADVLLALPSEESATVKDIEINe--------QSSEWAVAGHNVTLHLS 229 Tuber melanospo...
EPE10396     520 PLRLPISEVFRSAg---sTISASGRIEAGSLQVGDALMVVPGNVKAHIKSLLRDg--------QPADWAVAGQNVTLNLV 588 Ophiostoma pice...
KEZ40304     697 PFRMAISEIWKSPl---gHVTVSGRIDTGTTQIGDVLIVQPSGEEACVKTIMVDa--------DIRDWAVAGESVNIFLT 765 Pseudallescheri...
EWC46452     419 PLRMTITDVYRGGvt--nPVTISGRIEIGNVQVGDIIVAAPGEERAQVKGIEVDn--------EATDWAVAGNNVQLHLT 488 Drechslerella s...
KKF95769     691 PMRMMVSDLFSTGs---gKLTVSGRLEVGTVQVGDKLMITSSNEACYVQSLLVGr--------ESRDWAVAGENVDLVIV 759 Ceratocystis pl...
EMD88665     616 SLRLSVADVFKGDmr--sPLSISGRIDSGTLQIGDVILALPANETATIKSIEVQd--------APVDWAVAGQIPTLHLT 685 Bipolaris maydi...

Feature 1                       
3IZQ_1       480 KAYPeDIQNGDLAAS 494 baker's yeast
KLU86366     666 NIDPiHVRTGDIVCS 680 Magnaporthe poae ATCC 64411
EQL04042     716 NVDPiHIRVGDIVCD 730 Ophiocordyceps sinensis CO18
ERT01923     712 NIDPlNVRPGVLLCD 726 Sporothrix schenckii ATCC 58251
XP_002841365 230 GIDIiHLKPGDVLCS 244 Tuber melanosporum Mel28
EPE10396     589 NINVlHVYPGVVLSD 603 Ophiostoma piceae UAMH 11346
KEZ40304     766 GIDPnHLRVGDIMCA 780 Pseudallescheria apiosperma
EWC46452     489 GIDMdHLKIGDVVCH 503 Drechslerella stenobrocha 248
KKF95769     760 GVEAtSVSSGDVLSA 774 Ceratocystis platani
EMD88665     686 DIDPvHLRQGDIICA 700 Bipolaris maydis C5

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