3J36,3J25


Conserved Protein Domain Family
Tet_III
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cd16258: Tet_III 
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Domain III of Tetracycline resistance protein Tet
Tetracycline resistance proteins, including TetM and TetO, catalyze the release of tetracycline (Tc) from the ribosome in a GTP-dependent manner thereby mediating Tc resistance. Tcs are broad-spectrum antibiotics. Typical Tcs bind to the ribosome and inhibit the elongation phase of protein synthesis, by inhibiting the occupation of site A by aminoacyl-tRNA.
Links
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Statistics
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PSSM-Id: 293915
Aligned: 13 rows
Threshold Bit Score: 107.031
Created: 23-Jul-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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S12 interface
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:S12 interface [polypeptide binding site]
Evidence:
  • Structure:3J36; Campylobacter Tetracycline Resistance Protein TetO bound to ribosomal protein S12, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ##  #   #          # #     #                              
3J36_1    344 PMIQTTIAVkkSEQREILLGALTEISDCDPLLKYYVDTTt-HEIILSFLGNVQMEVICAILEEkyHVEAEIK 414 Campylobacter jejuni subsp...
3J25_A    343 PLLQTTVEPskPEQREMLLDALLEISDSDPLLRYYVDSTt-HEIILSFLGKVQMEVISALLQEkyHVEIELK 413 Enterococcus faecalis
Q51238    344 PLLRTTVEPskPEQREMLLDALLEISDSDPLLRYYVDSTt-HEIILSFLGKVQMEVISALLQEkyHVEIELK 414 Neisseria meningitidis
P09757    344 PLLQITVEPskPEQREMLLDALLEISDSDPLLRYYVDSTt-HEIILSFLGKVQMEVISALLQEkyHVEIELK 414 Ureaplasma urealyticum
P20174    344 PMLQTTIAVkkSEQREILLGALTEISDGDPLLKYYVDTTt-HEIILSFLGNVQMEVICAILEEkyHVEAEIK 414 Streptococcus suis
Q46306    352 PALKTTISAidKEKNPELFKALTLLAEEDPLLAFAMNDId-KEIYVNLFGEVQMEILSSMLDDlyGIKVEFS 422 Clostridium perfringens
P70882    345 PALKSSVRPnkPEERSKVISALNTLWIEDPSLSFSINSYs-DELEISLYGLTQKEIIQTLLEErfSVKVHFD 415 Bacteroidales
Q02652    353 PTLQTLVRArhPEQAAPLRSALLALADQDPLLHARPAAS--GATALLLYGEVQMEVLAATLAEdfGIEAEFT 422 Streptomyces lividans
Q55002    361 PSLETVIRPerPEEAGRLHAALRMLDEQDPSIDLRQDEEnaAGAVVRLYGEVQKEILGSTLAEsfGVRVRFD 432 Streptomyces rimosus
NP_354354 351 PTLETRVVSrrPSEHAALWLALNQMVEQDPLIGLRRNDEt-NEVFVSLYGEVQKQIIQSELSTgfGIEAEFE 421 Agrobacterium tumefaciens ...
YP_037124 350 PQMEAAIDAvpKERIHDLYAALMELCEEDPLIKVWKDDVh-NELYIRLFGQVQKEVIETTLFEkyNLQVTFS 420 Bacillus thuringiensis
Q48791    344 PMLQTTIEPckSVQREKLLDALFEISDSDPLLQYYVDTVt-HEIVLSFLGEVQMEVTCTLIQEkyHIEIETR 414 Listeria monocytogenes
O52836    344 PMLRTTIAPktAAQRERLLDALTQLADTDPLLRCEVDSIt-HEIILSFLGRVQLEVVSALLSEkyKLETVVK 414 Butyrivibrio fibrisolvens

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