Conserved Protein Domain Family
EFh_PI-PLCdelta3

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cd16218: EFh_PI-PLCdelta3 
EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)
PI-PLC-delta3, also termed 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3), phospholipase C-delta-3 (PLC-delta-3), is expressed abundantly in brain, skeletal muscle and heart. PI-PLC-delta3 gene expression is down-regulation by cAMP and calcium. PI-PLC-delta3 acts as anchoring of myosin VI on plasma membrane, and further modulates Myosin IV expression and microvilli formation in enterocytes. It negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and plays an essential role in normal neuronal migration by promoting neuronal outgrowth in the developing brain. Moreover, PI-PLC-delta3 is essential in trophoblasts for placental development. Simultaneous loss of PI-PLC-delta3 may cause placental vascular defects, leading to embryonic lethality. PI-PLC-delta3 contains a core set of domains, including an N-terminal pleckstrin homology (PH) domain, four atypical EF-hand motifs, a PLC catalytic core, and a single C-terminal C2 domain. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. In addition, PI-PLC-delta3 possesses a classical leucine-rich nuclear export sequence (NES) located in the EF hand motifs, which may be responsible transporting PI-PLC-delta3 from the cell nucleus.
Statistics
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PSSM-Id: 320048
Aligned: 6 rows
Threshold Bit Score: 245.811
Created: 18-Nov-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:EF-hand motif [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##############################                                                  
Q8N3E9       186 WIHSYLHRADSNQDSKMSFKEIKSLLRMVNvdmndmYAYLLFKECDHSNNDRLEGAEIEEFLRRLLkrpELEEIFHQYSG 265 human
A5D6R3       163 WIRGYLRRADQNQDGKMSYDEVKHLLQLINidlneqYARTLFKKCDRSCDGRLDHVEIEEFCREMMrrpELDAVFRHYSG 242 zebrafish
ETE73806     225 WIHGILHEADKNKDNKMSFKEIKNMLRIVNidmndiYAYQLFKECDKSNNDRLEESEIEEFCTRLMkrpELEDIFHQYSG 304 king cobra
XP_007234154 177 WIHENLKKADLNNDGVLTFEEMKTLLQMVNidldeqHASQLFKECDQSGDMLLENEEIETFCCRLLqrpELENVFDQYSS 256 Mexican tetra
XP_007908389 154 WIHEYLRRADANKDKKMSLEEIKDLLKLINievyeeYTLLLFKQCDRSKSSKLEEHEIEEFCQLLMqrpELEEIFNYYSG 233 elephant shark
XP_002935564 174 WIWDYLRQADRDGDEKMTFQEVKDMLKMINidlndiYAYNLFKACDRSNTNTLEDHEIEEFCTKLMhrpEVEEIFHHYSG 253 western clawed ...
Feature 1                                                                   
Q8N3E9       266 EDRVLSAPELLEFLEDQGEEGatlaRAQQLIQTYELNETAKQHELMTLDGFMMYLLSPE 324 human
A5D6R3       243 NGCVLTTLELRDFLGDQGEDAsl-vHAKSLIQTFELNDWAQKNLFMTQNGFTMYMLSKE 300 zebrafish
ETE73806     305 EDCVLSAEELQEFLHDQGEEAsl-qQAQHIIQTYELNEKARQHNLMMLDGFTMYLLSSA 362 king cobra
XP_007234154 257 KSHVLSTVKLRKFLKEQGEDStl-vHAENLILTYELDESAKQAQKMTLGGFTMYMLSKN 314 Mexican tetra
XP_007908389 234 EDQILAVREISNFLKEQKEVPse-eNAVELIERFELNEKAKQNQLLTQDGFVMYMLSPD 291 elephant shark
XP_002935564 254 EDRVLSAEELQEFLQAQGEDAtl-eRAKELIQKYELNETAKQHDLMMMEGFMMYLLSDD 311 western clawed frog

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