Conserved Protein Domain Family
ARSK
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cd16171: ARSK 
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor
ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Links
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Statistics
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PSSM-Id: 293781
Aligned: 5 rows
Threshold Bit Score: 676.567
Created: 30-Jun-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activemetal bindingputative
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##                                      #                               
Q6UWY0     32 PNVVLVVSDSFDGRLTFHPGSqVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTT 111 human
Q08CJ7     27 PNIVMIMSDAFDGRLTFQPGNkVVQLPYINYMRELGSVFLNSYTNSPICCPSRAAMWSGQFVHLTQSWNNNKCLHPNATT 106 zebrafish
Q5ZK90     33 PNVLLVACDSFDGRLTFYPGNqTVDLPFINFMKRHGSVFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPDYVT 112 chicken
Q0IHJ2     34 SNVVMVMSDAFDGRLTLLPENgLVSLPYINFMKKHGALFLNAYTNSPICCPSRAAMWSGLFPHLTESWNNYKCLDSDYPT 113 African clawed frog
EEN50564   29 KNIVFVICDSMDGRLIGRGQDsVVDLPNLNYMVQNGVNFRSTYTNSPICCPSRSALWSGLHTHVTQSWNNYKGLPKNYPT 108 Florida lancelet

Feature 1                     # #                                                             
Q6UWY0    112 WMDVMERHGYRTQKFGKLDYTSGHHSISNrveawtrdvafllrqegrpmvnlirnrtkvrvmERDWQNTDKAVNWLRKea 191 human
Q08CJ7    107 WMDDLRKSGYHTHSMGKLDYTSGHHSVSNrveawtrdvpfllrqegrpvtdlvgdastkrvmIKDWTITDAAVQWIRNtt 186 zebrafish
Q5ZK90    113 WMDLMQKHGYYTQKYGKLDYTSGHHSVSNrveawtrdvefllrqegrpkvnltgdrrhvrvmKTDWQVTDKAVTWIKKea 192 chicken
Q0IHJ2    114 WMDIVEKNGYVTQRLGKQDYKSGSHSLSNrveawtrdvpfllrqegrpcanltgnktqtrvmALDWKNVDTATAWIQKaa 193 African clawed frog
EEN50564  109 WQVRLEQQGYHTQVYGKTDYVSGDHSESNrveawtrnvnftlaqegrptpvlvgssstdriqLKDWASTDLASHWLLHea 188 Florida lancelet

Feature 1                     #                                                               
Q6UWY0    192 inYTEPFVIYLGLNLPHPYPSPSSGENFGSstfhtslywlekvshdaikipkwsplsemhpvdyyssytknctgrftkke 271 human
Q08CJ7    187 asLTQPFALYLGLNLPHPYRTDSLGPTAGGstfrtspywlnkvsynqvsvpkwlrfkdmhpvdyystvtkncsghfteee 266 zebrafish
Q5ZK90    193 vnLTQPFALYLGLNLPHPYPSPYAGENFGSstfltspywlekvkyeaikiptwtalsemhpvdyyssytknctgeftkqe 272 chicken
Q0IHJ2    194 qnHSQPFFLYLGLNLPHPYPSETMGENFGSstfltspywlqkvpyknvtipkwkplqsmhpvdyyssytknctapfteqe 273 African clawed frog
EEN50564  189 pkQQKPWLLYLGLNLPHPYPTPSMGKNFGGstfmtspywlkkvnsskvtipkwlpfsrmhpvdyyssatknctsdftrde 268 Florida lancelet

Feature 1                                              ##                                     
Q6UWY0    272 IKNIRAFYYAMCAETDAMLGEIILALHQlDLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGikaGLQV 351 human
Q08CJ7    267 IRNIRAFYYAMCAETDGMLGEVMAALRDtGSLNKTVVLFTSDHGDLAMEHRQFYKMSMFEGSSHVPLLIMGPGvksGFEV 346 zebrafish
Q5ZK90    273 VRRIRAFYYAMCAETDAMLGEIISALQDtDLLKKTIIMFTSDHGELAMEHRQFYKMSMYEGSSHVPLLVMGPGirkQQQV 352 chicken
Q0IHJ2    274 IRDIRAYYYAMCAEADGLLGEIISALNDtGLLGRTYVVFTSDHGELAMEHRQFYKMSMYEGSSHIPLLIMGPRispGQQI 353 African clawed frog
EEN50564  269 IMKIREYYYGMCAETDAMLGQVLDALKAsGQADSTYVFFTSDHGELAMEHRQFYKMSMYEASAHIPMVLTGPEvpaGKAV 348 Florida lancelet

Feature 1                                                                                     
Q6UWY0    352 SNVVSLVDIYPTMLDIAGIplpqnLSGYSLLPLSSetfkn-ehkvkNLHPPWILSEfhGCNVNASTYMLRTNHWKYIAYS 430 human
Q08CJ7    347 SLPVSLVDIYPTVLDLAGVpqtggLSGHSLIPLISrvsi----hsaEPHPAWAFSEyhGCNANTSTYMLRIAEWKYIAYA 422 zebrafish
Q5ZK90    353 SAVVSLVDIYPTMLDLARIpvlqnLSGYSLLPLLLekaed-evprrGPRPSWVLSEfhGCNVNASTYMLRTDQWKYITYS 431 chicken
Q0IHJ2    354 STVVSLVDLYPTMLEIAGVqipqnISGYSLMPLLSassnknvspsiSVHPNWAMSEfhGSDANASTYMLWDNYWKYVAYA 433 African clawed frog
EEN50564  349 DDLTSLVDVFPTFMDIANAsqppgLNGTSLLPLLRnss------drVDRPDWVLSQyhGCNVNMSTYMLRTGSLKYVAFG 422 Florida lancelet

Feature 1                       
Q6UWY0    431 dg-asILPQLFDLSSDPD 447 human
Q08CJ7    423 dg-lnVPPQLFNLSKDES 439 zebrafish
Q5ZK90    432 dg-vsVPPQLFDLSADPD 448 chicken
Q0IHJ2    434 dg-dsVAPQLFDLSSDPD 450 African clawed frog
EEN50564  423 dgpnqVSSQLFDLDKDPD 440 Florida lancelet

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