2MXW


Conserved Protein Domain Family
OCRE_RBM5_like

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cd16162: OCRE_RBM5_like 
Click on image for an interactive view with Cn3D
OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins
RBM5 is a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor; it specifically binds poly(G) RNA. RBM10, a paralog of RBM5, may play an important role in mRNA generation, processing, and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. Both RBM5 and RBM10, contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.
Statistics
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PSSM-Id: 293881
Aligned: 18 rows
Threshold Bit Score: 75.8147
Created: 19-Jun-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:OCRE repeat 1 [structural motif]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ########                                           
2MXW_A         11 PVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGerRTYVPALE 66   human
CCD79234      477 PFPDTSKYIYDESTRFYYDPVTGLMYEPNSKYFYDRGSQQYYYWDQtkSTYLPVPQ 532  Schistosoma mansoni
KKF26232      948 EIPDMTNYLYDATSGFYYDPETTLYYDPNSRYFYNAQTQEYMYWDAtsKTYIPVPG 1003 large yellow croaker
XP_006821221  657 PTPDVSKYQYDPASGYYYDPTTSLHYDANSKYYYNSQTGQYLYWDAakSTYLPAPD 712  Saccoglossus kowalevskii
NP_608582     623 PTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQrrSTYVLATP 678  fruit fly
XP_011403932   80 DSGLPSTYMFDSASGFYYDTTTGLYYDPKTQYHYNSQTGQYCYYDAnkLAYISVNA 135  Amphimedon queenslandica
XP_009016988  471 TAPDQSRYVFDETSGYYYDSTTDLYYDKGSQYFYDNKTSCFLYWDDtvNAYVEVPN 526  Helobdella robusta
XP_002128897  504 AAPDPTKFKYDPTSGYYYDAVTGYYYDANSRYFYNSHTGEYMYWDMnsRSYVKVSQ 559  vase tunicate
KII72073      304 TPGDPSTYYFDPTSNYYIDPSTNFYYDSNTGTFYNPYTQQFLYLDEktKILIPFAT 359  Thelohanellus kitauei
EFX71814      466 VAPDLSKYVFDEKSGYYYDTATNLYYDSKTQYFYNPQTQQFCYWDSdkHSFVPVSA 521  common water flea

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