Conserved Protein Domain Family
FERM_F1_SNX31
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cd16122: FERM_F1_SNX31 
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 31 (SNX31)
SNX31 is a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal trafficking of cell surface proteins. It is a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells. SNX31 binds multiple beta integrin cytoplasmic domains and regulates beta1 integrin surface levels and stability. SNX31 contains a PX (Phox homology) domain and a FERM (Band 4.1, ezrin, radixin, moesin) domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).
Links
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Statistics
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PSSM-Id: 340539
Aligned: 4 rows
Threshold Bit Score: 172.63
Created: 13-Jan-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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key conserved
Feature 1: key conserved lysines, 2 residue positions
Conserved feature residue pattern:[KR] [KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:2(K33/r, K48/R, Ub numbering) of the 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering) are conserved in this family; may have roles other than chain linkage
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #                           #              
Q8N9S9    112 IATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLcreLLGYFGLFLIRFGKegkLSVVKKLADFELPYVSLGS 191 human
Q6DDY6    110 MPTVKLILRVYVPDGAAVELDVRTSDSAERVLEAALFRLGVsreLAEYFSLFITHKEAkgpFTVVKRIAAFELPFLTIWN 189 African clawed frog
KFO90331   66 IQTRKAFLDVYLANGSNIRLDIQTSDTADRMLEVTLYRMGLsrkLIKYFSFFFFQDHEsgaLSVVKKVAEFELPYVSLQS 145 Buceros rhinoceros...
KPP71504   72 IHRLNGVREVLLPDGRSVTIQVKASDTAQTVLETVFDQIGLpgdLRGYFDLFLVKGKGkedFRILKKLVPWELPRYTLEA 151 Asian bonytongue

Feature 1                       
Q8N9S9    192 SevENCKVGLRKWYMAPS 209 human
Q6DDY6    190 LedDQFQIEVRKWYMNPS 207 African clawed frog
KFO90331  146 MkeLHCKLGIRKWYMDPS 163 Buceros rhinoceros silvestris
KPP71504  152 GrmERWALMIRKSYIDLT 169 Asian bonytongue

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