Conserved Protein Domain Family
GPI_EPT_1
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cd16020: GPI_EPT_1 
GPI ethanolamine phosphate transferase 1; PIG-N
Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Links
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Statistics
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PSSM-Id: 293744
Aligned: 57 rows
Threshold Bit Score: 262.91
Created: 2-Dec-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activemetal bindingputative
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ##                                               #                  
Q6C0Z3     45 TPPAKRLFLIVGDGLRADKAfekvrhpttgeseylAPFLRSKV--MSDATFGISHtrmPTESRPGHVALIAGFYEDVSAV 122  Yarrowia lipolyti...
NP_650088  43 PPPADRLVVLVRDGLSAQSFlanr--------ctnVPLLRELFlhQGLVGISRPEt-iTYHSISPYISLFSGFNEDAASV 113  fruit fly
EDY68212   42 RPPADRLVVFLIDGLRAESFfann--------crgVPHLQKLFlnQGVVGISRGCa--PTMTRPGHIAIFAGFNEDPQAA 111  Drosophila pseudo...
EDW38067   43 GPPANRLVVFLTDGLRAETFfadn--------cssVPDLREVFvnQGLVGISRGSv--PTLVRSGQIAIFGGFYETPPLL 112  Drosophila persim...
EDW59851   42 EPPADRLVVFLVDGLRAESLfrhn--------lsaVPQLKNMFleRGLMGISRGNa--PTETRPGHIAIFGGFNEDAASA 111  Drosophila virilis
EDW16024   42 QPPADRLVVFLIDGLRAESLysnk--------wnvLPNLKHLFmdHGLIGISHGSa--PTESRPGHISIFGGFQEDAAAA 111  Drosophila mojave...
EAL28851   43 RAPADRLVVFVKEGLRANTFfedy--------cnnLPLLRQLFhkQGLVGICHPAeapTDSKFSSYLALFAGFYEDAASV 114  Drosophila pseudo...
EDW59852   41 YAPADRLVVFVIDDLSAKVFfeqr--------crnVPQLKKIFlhQGQVGINRVRv--ASKCRSAHLTLFSGRYEDYLAG 110  Drosophila virilis
EDV43214   43 PPPADRLVIFLRDGLSAQTFlsnk--------chsIPLLQNIFmrEGLVGISRPEt-tTYSSLSPYVSLFTGYNENAAVV 113  Drosophila ananassae
EDV94852   42 QPPANRLVVFLTHGLSAKSFfeyr--------crnLPDLRKIFlkQGQVGISHSPa--VTTFRSAQVSIFSGCYEDALAP 111  Drosophila grimshawi

Feature 1                                                                                     
Q6C0Z3    123 tkgwkenPVDFDSVFNQSrhtys-lgspdILPMFKHGAEDQSRIdaimyghdfedfTKGSIELDAFVFDHLDEIFDKskt 201  Yarrowia lipolyti...
NP_650088 114 argwlgtPASIDSIFDRCkrsfa-wttteLISRFPKIERPRELSfety----gegvTKSCSEMEDFVCRSVQRFLGGgsr 188  fruit fly
EDY68212  112 itnfewnPTRFDSIFNRSrhaig-wldktVSDFFARSGGAPLRFetyr-----ysdFSRRFKTDTWVYNKAREFLTNnes 185  Drosophila pseudo...
EDW38067  113 rtgfqwnPSTFDTVFNRSktslc--wiesQTNVYTKSLTRGMFQh----------hSSDPKPKDPWVLLQLRSYLGInet 180  Drosophila persim...
EDW59851  112 mtnfksnPTVFDTVLNRTagatw-awgakSVLQFFKILPDGGVPinldm--htpldFTESYQRHQWIYDKVRKLLDNlds 188  Drosophila virilis
EDW16024  112 lrnfkrnPSVFDTVFNRTmgaswawgsksVLQFLKYLPNHEMYLdmht-----eseLTGNKFTHKLLHSKVRKFLAGsfd 186  Drosophila mojave...
EAL28851  115 ahnwllnPAPFDSIFNRSaysya-wttahMKQRFPDIDLPTVLSpevt-----pgvRKNCNEMEESVIRAVELFLLSesq 188  Drosophila pseudo...
EDW59852  111 l-----hGIAFDTIFNRStrsfa-wgsadLLQHFPAVHEVYTHPpni------pglGISSYKLDEWAFQAVRNFLRNkas 178  Drosophila virilis
EDV43214  114 arg-wvqYPTLDTIFRRSyrsya-wttsaVLRRLPDIGNQAKVInykt----rshgTTAHFQPEKATFYAVEKLLTKesr 187  Drosophila ananassae
EDV94852  112 v-----hGVAFDTIFNRSmrsya-wapgeLLQYFPAIYKMKTLPnei------snwAEDSSKLDEWSFKAVVDFLDSeap 179  Drosophila grimshawi

Feature 1                           #                                                     ##  
Q6C0Z3    202 nktlddqlrsDKTVFFLHLLGIDTAGHSyr------pySAEYYDNIKYIDENIEKLVDkvnkfyndDEQTAWVFTADHGM 275  Yarrowia lipolyti...
NP_650088 189 l-----llntTGVIFFIHMTGVEPSCES----------LQRIQENVWNVYKSFEKTFP--------DQRTAYLFTSNLGD 245  fruit fly
EDY68212  186 ir---elqnaTAVVFLVYLLDIDKAGHVft------plHREYRKRLYLTQKRIRETYDlfes-afnNSRTAYLMTSDHGM 255  Drosophila pseudo...
EDW38067  181 vd---klrskTSLILFVYLGNIATEGPL----------SKRYLERLHSAQRGIRETYDlies-tfnDSRTAYLMTSSHGI 246  Drosophila persim...
EDW59851  189 et----agnkLPAVFLVDFENIHSVVNAsktnrkeflkAIDNAETVAKLYDLFEHIFE--------DSRTVYLLTSDHGM 256  Drosophila virilis
EDW16024  187 ns----tlpsVYLVDFNSLVGNEIVLKPn---------SDEFLKALNNTETVINQLYNlfeq-yfgDQRTVYLLTSDHGM 252  Drosophila mojave...
EAL28851  189 e-----lqehRGLFFFVHLMLGEDASGApat----cenLKFTDRSVWKMYNRFEDCFP--------DQRTAYLLTSDFGL 251  Drosophila pseudo...
EDW59852  179 q-----lehlQGVVFFVQLLSLREATGFrmy----qeqLNYTQRRIWTIYQRFEHAFP--------DQRTAYLLTSDHGR 241  Drosophila virilis
EDV43214  188 r-----lrnmTGLVFFIHLTGEEPSSQN----------LHQIESNIHKMYQLFEDFLP--------DKRTAYLLTSNLGN 244  Drosophila ananassae
EDV94852  180 q-----lqhlRGLVFIIQLLGLQVSNGIkmf----henLNYTQRGIWTTYKRFLQAFP--------DRRTAFLLISHHGK 242  Drosophila grimshawi

Feature 1                                                                                     
Q6C0Z3    276 SDWGSHGDGHpdNTRTPLIAWGAGvnkpipafedkgnhddysevwdlpvkrNDVNQADIASLMSYLVGLNYPSNSVGELP 355  Yarrowia lipolyti...
NP_650088 246 PQTKSEYSLAv-ESPFFLWGSGVNhiksmpgrsfm------aneaglrlplHVLNTPHLTALMSALLGVPPPVYSRGMLP 318  fruit fly
EDY68212  256 SDVGHHGGGSdmEIEMPFFFWGAGvkhlgppgsqln---ftanahglqmplQELEQIQLAPLMSALIGLPPPTNNRAPLP 332  Drosophila pseudo...
EDW38067  247 SHLGSNVAGSrdETDTPFFLWGSGvrqtahnvaptf----aannaglqrplIDLQQIQLAPIISALIGEPPPVNNLGRFP 322  Drosophila persim...
EDW59851  257 TDKGTHGGDSqfEIETPFVFWGAGikgveppirgvq----sinsdafpmqfQKMKQTQLAPLMSALIGLPPPMNNRAMLP 332  Drosophila virilis
EDW16024  253 TDNGDHGEDSlfEIEMPFIFWGAGierlespfkdiy----aaktngtpmqfQELKQEQLAPLMSALIGLPPPLNNRATLL 328  Drosophila mojave...
EAL28851  252 PHSCGGPNKSnsLVEAPFFLWGSGvnhlttirgrsf----vvnaqkmrlplHVLSPIQLTTLMSALLGQAPPANNRGELP 327  Drosophila pseudo...
EDW59852  242 PEKGYSNGSSnqELETPFVLWGAGvahisagpgrsf----vanelgqrlplHILESIQLTPLMSGLLGLPTPVHNRGQLS 317  Drosophila virilis
EDV43214  245 PQTKTECKLAv-ESPFFLWGSGVAhiksmpgrsfv------anstgfrlplHVLHPPQITALMSAMLGLAPPVNSRGILP 317  Drosophila ananassae
EDV94852  243 PVWGFPASKSkqELETPFLLWGAGvsnsnsrlgrtf----vaneqqqrlplHVLEPVQLTPLMSGLLGLPPPVNNRGQQP 318  Drosophila grimshawi

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