Conserved Protein Domain Family
PLC

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cd16014: PLC 
non-hemolytic phospholipase C
Nonhemolytic Phospholipases C is produced by pathogenic bacterial. The toxic phospholipases C can interact with eukaryotic cell membranes and hydrolyze phosphatidylcholine and sphingomyelin, leading to cell lysis.
Statistics
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PSSM-Id: 293738
Aligned: 24 rows
Threshold Bit Score: 380.836
Created: 3-Dec-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activemetal bindingputative
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                                      
NP_421825  40 VEHVVILMQENRSFDHYFGTLNGVRGFGDrfpipvrdaagrkessvfvqawsk-----------dkllapfplnsaqtfa 108 Caulobacter cresce...
CEI93216   37 IKHVVFFMQENRSFDMYYGTMYGVRGFQDpnvgiqdnglslfyqpcsaspdi------------kngtkyllpyqlkger 104 Rhizopus microsporus
GAM20538   78 IKRIIVFMQENRAFDHYFGALAGVRGFNDpnvgtapdnvfsqpslnnav------------------ngysipyyiqgnk 139 Acytostelium subgl...
CCE32647   26 VKHIVLFMQENRAFDHYFGTMSGVRGFGDpnvqinpdgrstfeqaiqpqngvn----------ilkpwhinylggewtsa 95  Claviceps purpurea...
KIJ53621   30 IEHVVLFMQENRAFDHYFGTMAGVRGFGDpnvhiasdgkpvwfqkvdgtlsnat--------tqllpfyvnaaggnisea 101 Sphaerobolus stell...
EDP44585   27 IRHIVLFMQENRAFDHYFGSMAGVRGFQDpnahisnntgkdvfhqpvkasalasysrpknnetellpwhlnwqggdwynr 106 Malassezia globosa...
EJT98678   26 IEHVVFFMQENRAFDHYFGTLYGVRGFQDpnaqinadgksvfyqkvnsslsnat--------dyllpwyinyqggdylng 97  Dacryopinax sp. DJ...
KIK60377   25 VEHIVLFMQENRAFDHYFGTMAGVRGFKDpnvqidtdgrsvffqqvnpflsndt--------dfllpwyiaaeggefing 96  Gymnopus luxurians...
EXJ89251   28 IKHVVMFMQENRSFNHYFGTMAGVRGFSDpnvpinpktgkpvwyqdvstltdet--------dyllpfwlnyagdewktr 99  Capronia epimyces ...
EON99301   25 VKHVVMLMMENRSFQHYFGTMAGVRGFADpnvqvnpdgrsvwyqnltgvtdead--------wllpyylnyqggeesank 96  Togninia minima UC...
Feature 1                                                                         #           
NP_421825 109 hmrvegtPHSWTDAQDAWDQGRMDRWPDAKk--PWSMGYFQRADIPFQFALADAFTLCDAYHCSTQTGTNTNRLFLWTGT 186 Caulobacter cresce...
CEI93216  105 agctaggSNYWEPFHRALNNGMNDNWPDGNs--PKSMGYLTRSQIPFHYALADAFTIHDMYFQSVAGPTHPNRVVWMSGT 182 Rhizopus microsporus
GAM20538  140 alctgggVISWEETHDCYNNGLNNGWTSALgntTATMGYLTGAELSLYYALAHSYTIGDNYHASLLSSTFPNRIMHLSGT 219 Acytostelium subgl...
CCE32647   96 tqcmgagDNGWGAMHSAFSGGLGNNWANADg--PWSLGYYKRQDIPTHFDIAEGWTVADMASQSILAATDPNRIFWMSGS 173 Claviceps purpurea...
KIJ53621  102 sqcmvagSNGWTANHNALNGGDNNLWALKNs--PFAFGYFKREDLPAHFSIAEGWTLADMYAEAVIASTIPNRAFWASGS 179 Sphaerobolus stell...
EDP44585  107 tqcmvagSNSWQANHAAWNNGQIDQWVNKNt--PYSIGYYRREDVPVHFALAESFIVGDAYYESALASTYPNRAIHLSGS 184 Malassezia globosa...
EJT98678   98 tqcmdggSNSFENNHAAYANGTNDMWALDNn--PASIAYFKRQDLPIHYAIADAWTIGDMYQEAQMASTWPNRVHWITGT 175 Dacryopinax sp. DJ...
KIK60377   97 tqcmvggSNGWAENHAALASGRNDLWVEANt--PQSWGHFRRSDIPVQFAIAEGWTVGDMYQQGVIASTDPNRILWQSGS 174 Gymnopus luxurians...
EXJ89251  100 tqcmnpgSNDWAHTQSAMNNGSMDLWAVHSa--PQALGYFKKEDIPFHWALAEAYTVGDHYTASILSNTDPNRWFWQSGS 177 Capronia epimyces ...
EON99301   97 sqclcagANNWIPTHQSLNDGLNNAWAQISt--PQSWGYFKQQDIPYHFKLAESYTISDAYHAAITSNTDPNRWFWQSGT 174 Togninia minima UC...
Feature 1                                                                                     
NP_421825 187 ndglgkaggpsisn---------------------shdnfaekggakeSYTWTTYPERLLQAGVSWRIYQDmadnftdnp 245 Caulobacter cresce...
CEI93216  183 nkdphgsrv-------------------------------ftnnidfpPLTWSTYPEMLTKAGITWQVYQGldnfdcnpm 231 Rhizopus microsporus
GAM20538  220 inprgydnp------------------------------ptwnnnitpPPTWLTMPEYLAHHQINWQTYQDgldafqcnp 269 Acytostelium subgl...
CCE32647  174 vnipgsptnpdgkggmi--------------idnsatpgceapglncfPFRWKSFPEYLEEAGISWQVWQDldnfednml 239 Claviceps purpurea...
KIJ53621  180 vnvpggpqtpdqggvsv---------------dnnetpgcdspgvscfPLQWKTFAEYLEDAGVSWQVYQDtdnfgdnpl 244 Sphaerobolus stell...
EDP44585  185 lnangsvvggqpdklggpvv--------dntntpgcqfsdngkpyscrPLTWKTVPEYLQEANITFRAYQDfdnfdedll 256 Malassezia globosa...
EJT98678  176 vnipggptnstqgpvldnndtpgscshltftnfitdktyetttnvscfPYDWVTVPEILQDLGVSWFVYQAddnfgcnel 255 Dacryopinax sp. DJ...
KIK60377  175 igvaggnvnttqgpvldnnqspg--cskltwrlengtelespqnyscfPYDWKTLPEFLEDAGISWKEFQAidnfgnnpl 252 Gymnopus luxurians...
EXJ89251  178 invpggpqplgsggivl---------------ddnqtpgcegenlncvPLDWPAVAEIYENAGVDWRCYMNkwdyatnng 242 Capronia epimyces ...
EON99301  175 invpggklpidaggvvl---------------dnnqspgcwgenldclPLQWPAFAQYLDEAGIDWRSYQEswdwatnsg 239 Togninia minima UC...
Feature 1                                                                        #            
NP_421825 246 lagfkayrday---------kdlpgsnprlkqlglstwhLDKLREDVVNGRLPQVSWIIAp-aADSEHPnpSSPAQGADY 315 Caulobacter cresce...
CEI93216  232 awfkqwql---------------lplgsaekkkalgklgLDAFYEAAEKGTLPQFSLIIGp-rELSEHPd-NTPAAGAWI 294 Rhizopus microsporus
GAM20538  270 llwfeqymdg-----------sfpttffnfhsgtynyteVEVLLDQLNTNTLPEGVYWIVapqQMIEHPi-NGPKAGQNF 337 Acytostelium subgl...
CCE32647  240 ayfeqyqa---------------aksgsalrekgnsypgLDAFYEAAAKGTLPQVSWIVGp-qELAEHPp-NMPKDGAWL 302 Claviceps purpurea...
KIJ53621  245 awfeqfqv---------------apaqsplatkgmsfigLDSFYQAAQNGTLPAVSYIIGp-eELSEHPp-WAPHDGGWL 307 Sphaerobolus stell...
EDP44585  257 fawsqyqk--------------saqektdlakhgmsfpgLHKFFEDAENGNLPEISYIFVp-aHLSEHPp-YMPQDGAWL 320 Malassezia globosa...
EJT98678  256 aafktfiegaasplndtdnplivngmtyswsdnndwqggFTRFKNDAMSGNLPQVSWVIPt-tELSEHPp-YTPRQGAWL 333 Dacryopinax sp. DJ...
KIK60377  253 qyfkfwedlgdnn-----ptselaqrglaraggggwqggLDLLKKRAAEGTLPAVSFYIGp-aELNEHPp-HRPMEGGWV 325 Gymnopus luxurians...
EXJ89251  243 fnyfnafmng-----------pansslrargtdfsaqnsLDAFYQDALNGTLPEVSWVFPp-gSLQEHPp-RAPVDGAWL 309 Capronia epimyces ...
EON99301  240 lfyfkafqda-----------pvnsslyqrglafdgdngLDAFKAAAANGTLPAVSWVFPp-gSLQEHPp-KTPKDGSWF 306 Togninia minima UC...
Feature 1                             ##                                                      
NP_421825 316 TARVIDALTADPkvWARTVFLVMFDENDGFFDHVPPPAPPsydasgkllgastvdltaehhrvrnptearserddlmgrP 395 Caulobacter cresce...
CEI93216  295 QQQVVNAVMNGKn-WNNTALFINYDESGGFFDHVVPPQAPeseyvkd-------------------------pltgkqvP 348 Rhizopus microsporus
GAM20538  338 THTILEAVANSAl-HSDTVVLFNYDENGGLFDHVVPPVAPkgtidewi------------------------vndygasP 392 Acytostelium subgl...
CCE32647  303 QKKVVDAITNSPa-YGETVLIISYDEQGGWADHVVPPVAPkgtpgewlk---------------------dpynefgdvP 360 Claviceps purpurea...
KIJ53621  308 QQQVVNAVINSPk-YNSTVLMISYDETGGWGDHVLPITSPsgtagewlst-------------------dpfnpgpdpvV 367 Sphaerobolus stell...
EDP44585  321 HRKVLESLMKSKs-WNNTALVVSYDETGGWGDHVLGPLAPrdepgewmed--------------------pfhsklgwqP 379 Malassezia globosa...
EJT98678  334 QQEIINAIQKSPi-YNKTVLFISYDETGGWADHVLPFHSPagtpgewit----------------------dplaglstF 390 Dacryopinax sp. DJ...
KIK60377  326 LKEVVDALVSSPk-YNKTILMISYDESGGWGDHVIPFTSPentpgewii----------------------npftglpaP 382 Gymnopus luxurians...
EXJ89251  310 MKSLVDAVIHGPd-YNSTVFIIMYDEAGGFADHVWPFHSPygtpgewfq---------------------dpyneygytF 367 Capronia epimyces ...
EON99301  307 IDQIVSSIIDGPn-YNETIFMLNYDEAGGWGDAVKPLLPPegtagewfe---------------------dpygelgytY 364 Togninia minima UC...
Feature 1                                                   
NP_421825 396 YGLGPRVPLYVISPWSRGg----WVNSQVFDHTSVLRFLEQRFGVM 437 Caulobacter crescentus CB15
CEI93216  349 IGFGPRVPMVVISPWTRGg----NVFSEVSDHTSALRFLEEWIGKD 390 Rhizopus microsporus
GAM20538  393 IGPGFRVPFLIISPWTRDpanhgNVFTETADHTSILMFIEEWANQR 438 Acytostelium subglobosum LB1
CCE32647  361 LGPGWRVPKYIISPWTRGg----NVFTEFADHTSDIQFVEQWAAAQ 402 Claviceps purpurea 20.1
KIJ53621  368 AGPGFRLPFYVISPWTRGg----HVFTAHSDHSSQIMFVEKWLTAK 409 Sphaerobolus stellatus SS14
EDP44585  380 TGPGFRVPFYIASPFTRKg----GVFTEHAAHESQTLFMEEWAKVH 421 Malassezia globosa CBS 7966
EJT98678  391 AGPGFRLPFYAISPYSRGg----NVFTEVSDHTSQLLFLEKWAAAR 432 Dacryopinax sp. DJM-731 SS1
KIK60377  383 TGPGFRLPFTVVSPWSRGg----IVFTEPADHISQTLFLEQWAAAR 424 Gymnopus luxurians FD-317 M1
EXJ89251  368 SGPGVRVPLFLISPFTRGg----KVFTEHADHASQILFVEEFLKAK 409 Capronia epimyces CBS 606.96
EON99301  365 SGPGIRIPLIIVSPFTRGg----HVFTERADHSSILLFLEQYLAVK 406 Togninia minima UCRPA7

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