3UN2,3UO0,3M7V


Conserved Protein Domain Family
PPM
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cd16009: PPM 
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Bacterial phosphopentomutase
Bacterial phosphopentomutases (PPMs) are alkaline phosphatase superfamily members that interconvert alpha-D-ribose 5-phosphate (ribose 5-phosphate) and alpha-D-ribose 1-phosphate (ribose 1-phosphate). This reaction bridges glucose metabolism and RNA biosynthesis. PPM is a Mn(2+)-dependent enzyme and protein phosphorylation activates the enzyme.
Links
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Statistics
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PSSM-Id: 293733
Aligned: 158 rows
Threshold Bit Score: 315.544
Created: 29-May-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:includes metal binding sites and substrate and activator binding sites
  • Structure:3UO0; phosphorylated Bacillus cereus Phosphopentomutase binds a small molecule activator glucose 1,6-bisphosphate, contacts defined by 4A
  • Structure:3UN2; Bacillus cereus Phosphopentomutase binds Mn++ in the active site, defined by 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                                                                       
3UN2_A     10 KRIFLVVMDSVGIGEAPDAEq--fGDLGSDTIGHIAEhmnglQMPNMVKLGLGNIremkgiskvekPLGYYTKMQEKSTG 87  Bacillus cereus
3UO0_A     10 KRIFLVVMDSVGIGEAPDAEq--fGDLGSDTIGHIAEhmnglQMPNMVKLGLGNIremkgiskvekPLGYYTKMQEKSTG 87  Bacillus cereus
AEE92153    2 KRAILLVIDSLGVGEMDDVSkvrpQDKGANTLKHVAEsnddfTISNLETLGAGYLvdtkkikrvknPLASYGKSKLAHFG 81  Tepidanaerobacter ...
EIV99378    1 MRAIILVIDSLGVGEMADVPevrpQDIGANTLKHVSEyndnyRLNNLELMGAGLIvesknikkvsnPIASYGCSNLEHEG 80  Thermoanaerobacter...
KFM93395    3 KRVIIIILDSLGVGYMEDASdyhpLDVGANTFYHILDtvpslNIPNLEKLGINKIlhhpk-lknvdHIASYGVLNLMHQG 81  Bacillus lichenifo...
CCQ93454    2 KRAILVVVDSLGIGYMNDVHkyrpQDIGANTFGHILDkaksiEIPNFEKLGINNIinhnr-lsnidNIGSYGILNLEHYG 80  Clostridium ultune...
BAD39537    3 KRAIVLVLDGFGVGAMADVEqvqpRDAGAHTLASLVRsqgalRIPSLVRLGLPHIapeaglepagpPLAAWGRCNLAHWG 82  Symbiobacterium th...
KIL50049    2 RKMTLLVLDGFGIGAMDDCKivkpEDVNANTYKHIREav-dlLIPTLYKLGLGKIvdn-----egvPVAAYGKSNLAHPG 75  'Jeotgalibacillus ...
BAD63217    2 GKATLLVLDGFGVGAMADCRetkpEDIHASTYAHLQEtv-glNLPTLMKMGLGKIvnn-----egeAIAAYGKSKLAHHG 75  Bacillus clausii K...
CCQ94287    2 KRAVLCVLDGFGAGAMEDVSavrpQDRNANTMRHVIEqt-svKIPFLSRLGLPHIlndpsllaltpPLASYGKCNLYHYG 80  Clostridium ultune...

Feature 1       #                                             ##                   #   # # #  
3UN2_A     88 KDQMTGHWEIMGLYIDTPFQVfpegFPKELLDELEEKtGRKIIGNkpaSGTEILDELGQEQMETGSLIVYTsaDSVLQIA 167 Bacillus cereus
3UO0_A     88 KDXMTGHWEIMGLYIDTPFQVfpegFPKELLDELEEKtGRKIIGNkpaSGTEILDELGQEQMETGSLIVYTsaDSVLQIA 167 Bacillus cereus
AEE92153   82 ADTYQGHQEIMGSKPKKPVEK----PFAYYIDKVEHAlLKKGYRVt--RPNLKHPFLLVNDLVTIADNIEA--DPGQNYN 153 Tepidanaerobacter ...
EIV99378   81 ADTFQGHQEIVGSKPRKALVQ----PFKECMDKVKTElEKAGFDVt--IPDSKHPFLLVNGVVTIADNIEA--DIGLNYN 152 Thermoanaerobacter...
KFM93395   82 ADSFEGHNEIMGTKPKKTYLA----PFAEHINHVKLAlEDQGYKVn--IPNSDLPYLLVNDLVVVADNIET--DYGQIYN 153 Bacillus lichenifo...
CCQ93454   81 ADSYVGHQEIMGTKPKKPLLE----PFSFFREQVIDKlIKEGHKVt--CPEENKPYILVDDLVVVADNIET--DYGQIYN 152 Clostridium ultune...
BAD39537   83 ADTFAGHNEIQGNRPLRPVIS----LFSTVAGQVRAHlEQAGHRVe--DALPGGSALLVDGQILVGDNLET--DPGRIYN 154 Symbiobacterium th...
KIL50049   76 ADTFLGHQELMGSKPKEPNKR----LMMDVGIHIKAAlEAKGYEVk--YAVDRGTALLVNGSVVIGDNLES--QLGNIIN 147 'Jeotgalibacillus ...
BAD63217   76 ADTFMGHQELMGSKPGKPAKR----LMKEVGQQIADGlIANGYHVe--ELIEGKPILLVDGAVVVGDNLES--ALGNIIN 147 Bacillus clausii K...
CCQ94287   81 ADSYTGHNEIMGAKPIMPKTQ----FIRELAPLIEKRlVEKGFKVe--YPVAGTGILLVDNEVVIADNMEN--DPGQIIN 152 Clostridium ultune...

Feature 1                                     # # #                                  #   #    
3UN2_A    168 AHEEVVP--LDELYKICKIARELTldekymvGRVIARPFVGepg------------------------nfTRTPNRHDYA 221 Bacillus cereus
3UO0_A    168 AHEEVVP--LDELYKICKIARELTldekymvGRVIARPFVGepg------------------------nfTRTPNRHDYA 221 Bacillus cereus
AEE92153  154 VTAPLDYisFQDELAIGRIVRENVe-----vGRVIVLGGRGitvedilnaveikqnniigidcpksgvykSGYMVRHLGY 228 Tepidanaerobacter ...
EIV99378  153 VTAPLDYisFEEELKIGQIVRDNVk-----vGRVIVLGGKVitindilnaveeksdnivginctkagvynKGYMVRHLGY 227 Thermoanaerobacter...
KFM93395  154 VSAPLDYipFDEVLKIGRCVRHHVk-----vNRVIVLGGENvtpehlqrsverredglvgvnspksnvykQGYQVRHLGF 228 Bacillus lichenifo...
CCQ93454  153 VTAPLDYipFEKVIDIGKKVRSVVk-----vNRVIALGGEGvsveqilgsiekredgligvnspksgvynKGYLSRHLGY 227 Clostridium ultune...
BAD39537  155 VTGPLDTvpFERILEVGRRVRQVVq-----vSRVIALGGVGitvedilahtritpagqtgvvtpelhiynEHYRVRHLGY 229 Symbiobacterium th...
KIL50049  148 VVGDLNHlsFEELTEIGKIVRENVd-----tSRVIIFGNEKttietilsvvkenhpgqwgvdspkanvygEGYRVLHLGY 222 'Jeotgalibacillus ...
BAD63217  148 MTADLTQisFEAATKMAAVVRKHVd-----tSRVIVFGNESvpltdivaaaeegkpgqwginapktgvygEGYQVLHLGY 222 Bacillus clausii K...
CCQ94287  153 ITGALDTtpFEKIFEIGKIVRTIAe-----tSRVIPLGGTGitvsdillnivikp-ertgvdmgrlniynENYQVRHLGF 226 Clostridium ultune...

Feature 1                            #                                                 #     #
3UN2_A    222 LKPfgrTVMNELKDSDYDVIAIGKISDIYDGegVTESLrtksNMDGMDKLVDTLNMd----fTGLSFLNLVDFDA-LFGH 296 Bacillus cereus
3UO0_A    222 LKPfgrTVMNELKDSDYDVIAIGKISDIYDGegVTESLrtksNMDGMDKLVDTLNMd----fTGLSFLNLVDFDA-LFGH 296 Bacillus cereus
AEE92153  229 GVNpevQIPSIMHKSGYQVSLIGKVADVIECe-GANYYpkveTEGVMELILEQMKLq-----HSGLIAANVQETD-LAGH 301 Tepidanaerobacter ...
EIV99378  228 GIDpnvQVTTILKKHGFDVSLIGKAADVINCd-GADYN----PCVDTETVLSILLNkl--dnISDGLIMANVQETdLAGH 300 Thermoanaerobacter...
KFM93395  229 GISpekQLPTLAKNGGMEVSLIGKMQDIIYCk-GANRFpgvdTEQVMKDIIQEMDRv-----KKGVIAATVQETD-LAGH 301 Bacillus lichenifo...
CCQ93454  228 GVNpekQISAILARNNYEVTLIGKMQDVIECe-KATKI----PAVDTEKVMKETLDsms-ylSEGIIAATVQETD-LAGH 300 Clostridium ultune...
BAD39537  230 GIDpavQAPELVASTGLPVAMIGKMADVVECp-SARWRd---PVVDTEAVLEQVLEqleqmpDGGYIAATVQETD-LMGH 304 Symbiobacterium th...
KIL50049  223 GVDyqkQFAYMAEQNNVPVYRIGKTADVIQAegFKDPVv--nTKDVLETYRSYYRNs----eENAVFLVNVQETD-LAGH 295 'Jeotgalibacillus ...
BAD63217  223 GVTfekQFAYLAEQAGKPVYRIGKTADVIQAqgFANPVv---HTPELLSIYKKMYNea---eEDAVFLVNVQETD-LAGH 295 Bacillus clausii K...
CCQ94287  227 GIDpdkQIHSILMKQGLEVYLYGKMADVITGe-VMERNpmvnSQGVMDLICNRLEN------MKSGFISATIQETdLAGH 299 Clostridium ultune...

Feature 1                                        ##          #                                
3UN2_A    297 RRDPQGYGEALQEYDARLPEVFAkLKEDDLLLITADHGNDPIHPGTDHTREYVPLLAYSpsmkeggqelPLRQTFADIGA 376 Bacillus cereus
3UO0_A    297 RRDPQGYGEALQEYDARLPEVFAkLKEDDLLLITADHGNDPIHPGTDHTREYVPLLAYSpsmkeggqelPLRQTFADIGA 376 Bacillus cereus
AEE92153  302 SQDYKRYAQKLMLADKYLGSIMRgMEKEDILIITGDHGNDPTIGHSHHTREKTLLLVYGkqlk--avnlKERETLSDIAA 379 Tepidanaerobacter ...
EIV99378  301 SQDVEKYAEKLKLVDDYLPKIIDkMKGDDILFITGDHGNDPTIGHNHHTREKALLLVYGkklr--pvklGERKTLSDIGA 378 Thermoanaerobacter...
KFM93395  302 AQNPVRYANRIEMVDQYLPEILRkMTDQDLLMISADHGNDPTIGHNQHTREKTYLLAYHkkls--paniGERKTLSDIAA 379 Bacillus lichenifo...
CCQ93454  301 AQDVEKYVKKLMIVDKYIGDIINsMKDGDILFITADHGNDPTIGFSQHTREKTFLLVYGkrln--kvalGERNTLSDIGA 378 Clostridium ultune...
BAD39537  305 EQDPVRYAEVLARADRGIARLLDrLRPGDLLIILADHGNDPLIGHSLHTREQVPLLAFGpgfr--paalGVRDTMADVAA 382 Symbiobacterium th...
KIL50049  296 KEDSQWYKEVLEESDRFLASFIEeMNDDDLLIITADHGNDPTIGHSNHTREQTPILIVGkhvk--avtiGTRDTMADIAA 373 'Jeotgalibacillus ...
BAD63217  296 KEDPSWYKEVLETVDHFLAEFLPtLAEHDLLIVTADHGNDPTCGHSQHTREHTPILVYGkqvq--pvclGIRDTMADIAA 373 Bacillus clausii K...
CCQ94287  300 EQNPEKFAAVLEIADAGLRRIYDmLHPGELLIVTADHGNDPTIGTSQHTRETTPLLVCVkgsp--arelGLRTTLADVAA 377 Clostridium ultune...

Feature 1                      
3UN2_A    377 TVAENFGVKMPEYGTSF 393 Bacillus cereus
3UO0_A    377 TVAENFGVKMPEYGTSF 393 Bacillus cereus
AEE92153  380 TIADYFNLDMPENGKSF 396 Tepidanaerobacter acetatoxydans Re1
EIV99378  379 TIADYFGVEKPENGESF 395 Thermoanaerobacter siderophilus SR4
KFM93395  380 TSADYLGLRNTENGSSF 396 Bacillus licheniformis
CCQ93454  379 TISDYFNVEKTENGSSF 395 Clostridium ultunense Esp
BAD39537  383 TVCEHLGAPAPEFGTSF 399 Symbiobacterium thermophilum IAM 14863
KIL50049  374 TMADFVGVEKPEFGKSF 390 'Jeotgalibacillus soli' Cunha et al. 2011
BAD63217  374 TLSDFTGVQTPEFGTSF 390 Bacillus clausii KSM-K16
CCQ94287  378 TIADYFGVSAPEFGTSV 394 Clostridium ultunense Esp

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