3SN6,4GBR,4QKX,2R4S,2RH1,5JQH


Conserved Protein Domain Family
7tmA_Beta2_AR
?
cd15957: 7tmA_Beta2_AR 
Click on image for an interactive view with Cn3D
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors
Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.
Links
?
Statistics
?
PSSM-Id: 341355
Aligned: 9 rows
Threshold Bit Score: 506.709
Created: 18-Sep-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
  next features
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3SN6: Bos taurus beta-2 adrenergic receptor binds a high affinity agonist (BI167107), contacts at 4A.
  • Structure:4GBR: Human beta-2 adrenergic receptor binds (s)-carazolol, contacts at 4A.
  • Structure:4QKX: Human beta-2 adrenoceptor binds a covalent agonist, contacts at 4A.
  • Structure:5JQH: Human beta-2 adrenoceptor binds carazolol, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   #   #
3SN6_R       183 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAAHILtktWTFGNFWCEFWTSID 262 cattle
4GBR_A         6 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAAHILtktWTFGNFWCEFWTSID 85  human
4QKX_A       183 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAACILtktWTFGNFWCEFWTSID 262 human
Q8UUY8        37 VLLGILMALLVMCIVFGNVLVITAIVRFQRLQtvTNMFITSLACADLVMGLLVVPFGACYILlntWHFGSFLCEFWTAAD 116 rainbow trout
XP_005298103  34 VGMGILMSVIVLVIVFGNVLVITAIAKFQRLQtvTNYFITSLACADLVMGLTVVPFGASHIMlkqWKFGNFWCEFWTSLD 113 western painted...
AAH60426      26 VAMGIVMSCIVLVIVFGNVLVITAIAKFQRLQtvTNYFIMSLACADLLMGLMVVPFGATYITldtWVFNNFWCEFWTSVD 105 African clawed ...
2R4S_A        11 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAAHILmkmWTFGNFWCEFWTSID 90  human
2RH1_A        41 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAAHILmkmWTFGNFWCEFWTSID 120
5JQH_A       183 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQtvTNYFITSLACADLVMGLAVVPFGAAHILtktWTFGNFWCEFWTSID 262

Feature 1        #  ##                                                                         ##
3SN6_R       263 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYAEETCCDF 342 cattle
4GBR_A        86 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYAEETCCDF 165 human
4QKX_A       263 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYAEETCCDF 342 human
Q8UUY8       117 VLCVTASIETLCVIALDRYLAITSPLRYPSLLtKRKACVVVVTVWGVAALISFLPIHMKWWVsdepealsCLEDAHCCDF 196 rainbow trout
XP_005298103 114 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKSKARIVILVVWVVSVLTSFLPIQMHWYRadgpdakrCYKNDTCCDF 193 western painted...
AAH60426     106 ILCVTASIETLCVIAVDRYFAITSPFRYQSLLtKCKARIVILLVWLVSALTSFLPICMHWYRveektaldCYQDPSCCFF 185 African clawed ...
2R4S_A        91 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYANETCCDF 170 human
2RH1_A       121 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYAEETCCDF 200
5JQH_A       263 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLtKNKARVIILMVWIVSGLTSFLPIQMHWYRathqeainCYAEETCCDF 342

Feature 1             #   ##  #                                                                  
3SN6_R       343 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIdksegrfhvqnlsqve------------------------ 398 cattle
4GBR_A       166 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIdk-------------------------------------- 207 human
4QKX_A       343 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIdk-------------------------------------- 384 human
Q8UUY8       197 nTNAAYAVASSVVSFYIPLAVMAFVYGRVFQEARKQLEKIrgsegrfhaqmidnnqgqd--------------------- 255 rainbow trout
XP_005298103 194 fTNQAYAITSSIISFYLPLVVMVFVYARVFQVAKKQLKKIdkcerrfhnqnnnqq------------------------- 248 western painted...
AAH60426     186 yTNPAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKIdksegrfhnqnqpq-------------------------- 239 African clawed ...
2R4S_A       171 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIdksegrfhvqnlsqve------------------------ 226 human
2RH1_A       201 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFemlrideglrlkiykdtegyytigighlltkspslnaaks 280
5JQH_A       343 fTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIdid------------------------------------- 385

Feature 1                                                                                        
3SN6_R           --------------------------------------------------------------------------------     cattle
4GBR_A           --------------------------------------------------------------------------------     human
4QKX_A           --------------------------------------------------------------------------------     human
Q8UUY8           --------------------------------------------------------------------------------     rainbow trout
XP_005298103     --------------------------------------------------------------------------------     western painted...
AAH60426         --------------------------------------------------------------------------------     African clawed ...
2R4S_A           --------------------------------------------------------------------------------     human
2RH1_A       281 eldkaigrntngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlqqk 360
5JQH_A           --------------------------------------------------------------------------------    

Feature 1                                                                    #  ##  #            
3SN6_R       399 ------------------------qdgrtghglrrsskfcLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 454 cattle
4GBR_A       208 --------------------------------------fcLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 249 human
4QKX_A       385 --------------------------------------faLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 426 human
Q8UUY8       256 ----------------------ggdgsgggggngkrpkfcLKEHKALKTLGIIMGTFTLCWLPFFVLNVVVTIwkvdnIK 313 rainbow trout
XP_005298103 249 -------------------------eqngrashrrtskfcLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdkiiPT 303 western painted...
AAH60426     240 --------------------------dangkqgnrrtskfLKEHKALKTLGIIMGTFTLCWLPFFIVNIVQVMhkdiiPD 293 African clawed ...
2R4S_A       227 ------------------------qdgrtghglrrsskfcLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 282 human
2RH1_A       361 rwdeaavnlaksrwynqtpnrakrvittfrtgtwdaykfcLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 440
5JQH_A       386 -------------------------------------kfaLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIqdnliRK 428

Feature 1          #   #   #                    
3SN6_R       455 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 485 cattle
4GBR_A       250 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 280 human
4QKX_A       427 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 457 human
Q8UUY8       314 MPFRILNWIGYANSAFNPLIYCRSPEFRYAF 344 rainbow trout
XP_005298103 304 NLYILLNWLGYVNSGFNPLIYCRSPDFRYAF 334 western painted turtle
AAH60426     294 KVYTFLNWVGYVNSAFNPLIYCRSPDFRYTF 324 African clawed frog
2R4S_A       283 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 313 human
2RH1_A       441 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 471
5JQH_A       429 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAF 459

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap