Conserved Protein Domain Family
7tmF_FZD4_9_10-like

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cd15909: 7tmF_FZD4_9_10-like 
class F frizzled subfamilies 4, 9, 10, and related proteins; member of 7-transmembrane G protein-coupled receptors
This group includes subfamilies 4, 9 and 10 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and their closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
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PSSM-Id: 320575
Aligned: 16 rows
Threshold Bit Score: 459.848
Created: 24-Jun-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human smoothened receptor bound to an antitumor agent.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #        #                                                 #                   
Q61088    209 GLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSrfsypERPIIFLSMCYNIYSIAYIVRLTVgrERISCDfeeaa 288 house mouse
AFA43479  224 VYFQRSDKDFTEMWMGVWAILCFVCTSITVLTFLIDRGrfkypERPIIFLSMCYNIYSITYVVRLIVgpQAVACEktssg 303 common urchin
EDO38567  209 LMFSSNNKRFANVWISVWSVLCFISTAVTVLTFVIDTSrfkypERPIIFLSLCYNLYSLGYIVRVTAgrNEVICDetesf 288 starlet sea anemone
EEN55067  182 VFFSRQDKEFVEIWMGIWSVVCVISTSVVILTFMIDSRrfrypERPIIFMAVCYFFYSIGFILRLGLgrETISCDmdrge 261 Florida lancelet
ESN94705  141 VMYRFTDKKFAEIWMILWAVLCLVSTLFTFLTFILDTTrfeypERPIIYLSMCCLVYSCGYIIRFARglSDVSCIesrhq 220 Helobdella robusta
EJW85305   95 GMFDVSKKEFARFWMLLWASINLGVTAFTVLTFIIDRQrfrfpERSIFYLSACYMLFSLPPLSRAVFpyERIVCDklptg 174 agent of lymphatic...
AFN44726  229 VFYTQKHKNFAYTWMAIWASLCIASTLFTILTFCIDPRrfrypTRPVIFMAFCYLIYALSYFIPLFIprEKIICKsdvqg 308 Bugula neritina
EFV53049   45 WMFTEEQKNFAQVWMAVWASVCFLSTGFTVMTFLLDTSrftypKRPIVFIAICYCATSVGYLLRLLVgrEAAGCQqldsg 124 Trichinella spiralis
CDJ19278  250 LFYRPGDKKFARAWLLGWSILCVASSALTFFTFFVDGSrlqypERPVLYLAACYFVIGVGYILQYSLgpERVTCRslqtg 329 Echinococcus granu...
ABW97516  190 VQFNAHDKVFANIWLLGWSVLCFFSCLLTIIVFSCNTNrflypEKPIVFLSICYFFYASGNLFGAILgrNVVACRafndk 269 Schmidtea mediterr...
Feature 1                                                                                     
Q61088    289 ep-------vliqeglKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGhEAIEMHSSYFHIAAWAIPAVKTIV 361 house mouse
AFA43479  304 vp-------ylimeglDTTGCTIVFLIQYYFFMASSIWWVILTLTWFLAAGMKWGyEAIAAYSSYYHVVAWALPALKTII 376 common urchin
EDO38567  289 vi-------ragmniaDHACCSVVFLLLYYFGMASAVWWVVLTFAWFLAAGRKWGqEAIERKATYFHAVAWTVPAIQTIM 361 starlet sea anemone
EEN55067  262 py--------liqeglESTGCTIVFLILYFFGMASSLWWVILTMTWFLAAGLKWGqEAIEAHSSYFHLAAWAVPAVKTIV 333 Florida lancelet
ESN94705  221 vs-------yviqeglENTWCVVVFLILYYFNMAGCIWWVILTSTFYFSAAKKWSrEALQKANNYFHVISWTLPAVLTTI 293 Helobdella robusta
EJW85305  175 qt-------flivgtlDNTSCVMSFILTYYFSVASSLWWLMLTFTWYLSAARKWVpEGIDAWSSYLHLVAWALPAILTIA 247 agent of lymphatic...
AFN44726  309 dl--------mvvngmESTLCVIIFLVQYYFGIASHVWWLILTFTWYLAASRKWVlEAINSIACYFHLFAWAVPAVLTVV 380 Bugula neritina
EFV53049  125 qs-------vlvshslSNAVCVVTFILLYYFGLASAVWWLILTMTWYLAAGRKWSqEAIARLSSTFHIIAWVIPASLTVT 197 Trichinella spiralis
CDJ19278  330 dsnaaemqkyllmggqESAWCTVGFLISYYFGMASNFWWVMLSLAWYLSTSRKWGhEGVESVSSVFHMFAWALPAIQAIL 409 Echinococcus granu...
ABW97516  270 td-------fivgsgrETTWCKINFLMIYFFGSASALWWVVLTITWFLSASRHWGyEAIESISSMLHLVSWAIPALKSIF 342 Schmidtea mediterr...
Feature 1              #    # #        #                                                      
Q61088    362 ILIMRlVDADELTGLCYVGnqNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLqkd-----gtkTDKLERLMVK 436 house mouse
AFA43479  377 ALAKHrLDADELTGMCYIGnhDPDVLTYYVLVPLFIYFAIGTLFILAGFFYLFRIRKVMkng-----gtnIDKLERLMVR 451 common urchin
EDO38567  362 ALIMRkVDADELTGLCYVGnmDYENLANYVLTPLCLYLLVGTFFLLAGFVSLFRIRTVLknk-----etnTDKLEKLIVR 436 starlet sea anemone
EEN55067  334 VLTLRrVDGDELTGLCYVGnqDQTALTWFVLAPLFTYLLLGTCFILAGFVNLFRIRKVMrhg-----gnsTERLEKLMSR 408 Florida lancelet
ESN94705  294 VLTMRrLDGDELTGLCFVGnqDMDSLLTFVLFPNMVFLIIGVYFIIGGFVAMFRIRQDLvsdg----cldVKKFEKLMMK 369 Helobdella robusta
EJW85305  248 VLTTHkVDANELTGLCSVGnvDPWALFGFIIVPKLIFVVVGSCLIVAGFSSMCRERDSFrrr-----gtdTSKLEKLMVK 322 agent of lymphatic...
AFN44726  381 ILVTGrVDSNELTGMCYVGnhDKWSLLIYIIIPTSFLCLVGEILMLAGFVSVLRIRTNLkthv---ddasVRKLEKLMAK 457 Bugula neritina
EFV53049  198 LLVTHeLEASELTSMCFVClhSSSALFGFVVGPVAVFSAIGICFMVAGIVSMVRISREMrfri---cdtdLQKLRKLMTK 274 Trichinella spiralis
CDJ19278  410 ILILHkIDADELTGTCYTGfhSETSLMFGVLLPQAICLLLGLLLLSVGFAAVFRVRRKLkapsd-reresRRRLEKSIAK 488 Echinococcus granu...
ABW97516  343 ILILHkIDADELTGQCFVGnsNNKVLWGFVIVPNMIYLFIGIVFLTMGYISLLKVRRSFlqrpdcidtnnLKRLEKLMAK 422 Schmidtea mediterr...
Feature 1                              #  ##                                  #    #  ##      
Q61088    437 IGVFSVLYTVPATCVIACYFYEISNWAlFRYs-----------------------------aDDSNMAVEMLKIFMSLLV 487 house mouse
AFA43479  452 IGIFSVLYTVPATAVIACYFYQRSNMEyWRIvaehapcrplpp--------eegggcapmdySIPSVPVLSVKLFMLLVV 523 common urchin
EDO38567  437 IGVFSVLYTIPVSAVIACSFYEYNNMDvWKVrapfntyic-------------rgdqaclenYGPSIEVFIVKYFMLLII 503 starlet sea anemone
EEN55067  409 IGIFSVFYTVPATCVVACYFYEQQNMStWTT-------------------------------TAQEIPCNNNIAFLLLVG 457 Florida lancelet
ESN94705  370 IGIFSILYTLPDICVVGCLFFEWLNFRdWRAaayltpcykfdds-----lnhqqlvdcslekSIPAVEVKVLKIFMSLVI 444 Helobdella robusta
EJW85305  323 MGIFSALYVIPAITIIICDSYHMFILMqWHPttiacklhgg------------iekghckrpPLPQVELYFLNIFMSLVI 390 agent of lymphatic...
AFN44726  458 IGVFAIFYTVPTVCVLGSNIHEFINMDtWRCmsslt---------------------stlvgSIPTVEIHILKISMSLIV 516 Bugula neritina
EFV53049  275 VCVFSLLYVVLTLIVVVCSVYEKFFDEeWLSsqfecrpqsfkdatt-gvglrhcnmsgmgslSPPAVEIYMLKVFISLTI 353 Trichinella spiralis
CDJ19278  489 LGVFVVLYTFPMACLLASNLYEYLGQPrWRAalrelntarphcls---prgvawglpechpkDSPSSEAAMLRIFMSFVV 565 Echinococcus granu...
ABW97516  423 IGVFSILYVLPVLCTIVSYIVDAYKMTnFDItlkalfrfspncigrnginwssikcvkilqpVLPSVEMRMLRIFMNLVI 502 Schmidtea mediterr...
Feature 1                            
Q61088    488 GITSGMWIWSAK-TLHTWQKCSN 509 house mouse
AFA43479  524 GITSGMWIWSSK-TVQSWQNWLG 545 common urchin
EDO38567  504 GITSNMWIWSTK-TFKSWRKFYS 525 starlet sea anemone
EEN55067  458 CFGTSLWICSNK-TMESWQNFCN 479 Florida lancelet
ESN94705  445 GTASGIWVWSPK-TVQLWTKFFK 466 Helobdella robusta
EJW85305  391 GISTGMWTVSSK-TFHSWQRAIC 412 agent of lymphatic filariasis
AFN44726  517 GVFIAMWVLNSK-TLQTCERKCS 538 Bugula neritina
EFV53049  354 GIISSMWIWSKK-TLLMWHHFFC 375 Trichinella spiralis
CDJ19278  566 GITSGMWVWANKkTLMSWNRVVF 588 Echinococcus granulosus
ABW97516  503 GITSGIWIWGNKkTVKSCISTLR 525 Schmidtea mediterranea

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