2NPS,1GL2,3B5N,1SFC


Conserved Protein Domain Family
SNARE_Qa

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cd15840: SNARE_Qa 
Click on image for an interactive view with Cn3D
SNARE motif, subgroup Qa
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins consist of coiled-coil helices (called SNARE motifs) which mediate the interactions between SNARE proteins, and a transmembrane domain. The SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles. Examples for members of the Qa SNAREs are syntaxin 18, syntaxin 5, syntaxin 16, and syntaxin 1.
Statistics
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PSSM-Id: 277193
Aligned: 70 rows
Threshold Bit Score: 50.5901
Created: 4-Apr-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterotetramerzero layer
Conserved site includes 45 residues -Click on image for an interactive view with Cn3D
Feature 1:heterotetramer interface [polypeptide binding site]
Evidence:
  • Structure:2NPS, Rattus norvegicus early endosomal SNARE complex, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # ## ###### ### ## ### ## ### ## ###### ###### ###### ### 
2NPS_B         1 GSMRETAIQQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERASDQLQR 59  Norway rat
EEC48261     226 KAMRQDEIDRMNRSMHKVNDIYKELGQLVEVQQEDIDLLEDTILDSKANVEAADWEFFC 284 Phaeodactylum tricornutum CCAP 1055/1
1717966      258 KNEQLKKVETINKTILDIVNIQNELSNHLTVQSQNINLMLNNQDDIELNIKKGNKELRK 316 Saccharomyces cerevisiae S288c
EHJ71164     202 AEARRDELQRVESSLKTVRDLFTQLAHLVATQQEHLDSVEYFASQATEHVECGGQELLK 260 monarch butterfly
XP_001633611 220 VEQREKEIQSIVQSISELNEIFRDLATMIVEQGSILDRIDYNVEQASVKVEQGLEQLKK 278 starlet sea anemone
EEB09830     173 AEETCENILKIEKSIMEIRNLFNELSFIVDLQQEKIQQIEHSVDVNLHKVEKGRKKIIS 231 human body louse
1SFC_B        16 IETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKK 74  Norway rat
AFW74686     183 QDEAAKEVAEVERGLLELQQLFLDMAALVEVQGAPLDDIEQQVGTAAGHVGAAEAELRE 241 maize
ELR18556     208 LKEKHRDIAKIEKDLVELNGIMQDIGQLVEYHNELLDQIEMNVEEGKAKVNLATQELAE 266 Acanthamoeba castellanii str. Neff
EOD22450     136 LSTHERQVAQLESSIVELQALFESMGLLVEAHGAVLDNVELSISEAARRVEAGTKHLQA 194 Emiliania huxleyi CCMP1516

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