1XG2,1X90


Conserved Protein Domain Family
PMEI
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cd15797: PMEI 
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Pectin methylesterase inhibitor
Pectin methylesterase (PME; Pectinesterase; EC 3.1.1.11; CAZy class 8 of carbohydrate esterases) catalyzes the demethylesterification of homogalacturonans in the cell wall. Its activity is regulated by the proteinaceous PME inhibitor (PMEI) which inhibits PME and invertase through formation of a non-covalent 1:1 complex. Depending on the mode of demethylesterification, PMEI activity results in either loosening or rigidification of the cell wall. PMEI has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension. It may also be involved in inhibiting microbial pathogen PMEs. Thus, PMEI probably plays an important physiological role in PME regulation in plants, possessing several potential applications in a food-technological context.
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Statistics
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PSSM-Id: 275441
Aligned: 91 rows
Threshold Bit Score: 74.7661
Created: 9-Jun-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1XG2: Actinidia chinensis pectin methylesterase inhibitor (PMEI) binds PME; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1XG2_B         2 ENHLISEICPKTRNPSLCLQALESdprs-askDLKGLGQFSIDIAQASAKQTSKIIASLTNqatdp-----klkgRYETC 75  Actinidia chine...
NP_191127     30 SIKDMYAFCKDTDDVNFCLKYIGTdirilaarDLHDVLVIAISQCQIQLTKATKQINKVRQkfsgp-----igtrRLYFC 104 thale cress
NP_567474     21 DEELIKTECNHTEYQNVCLFCLEAdpis-fniDRAGLVNIIIHCLGSQLDVLINTVTSLKLmkgeg----eanenVLKDC 95  thale cress
CDY63489      27 DKGLMIRECHNARVPTICMQCLESdpas-vhaDPVGIAGIVIYCLNSNLNVLTKQCSNITKlllkkekdgdairkALEGC 105 rape
NP_001154430  21 EKDLMKEECHNAQVPTICMQCLESdpts-vhaDRVGIAEIIIHCLDSRLDIITNNITNILSlgggt----kevrkILEDC 95  thale cress
NP_187894     28 NEELMMQQCHNSDNPTLCLRCLSSdpgs-heaDKVGLARIILKCINSHLLVLTKNASTLGSqhyqn----pntaaALKQC 102 thale cress
EXB53373      35 DRGLIQIVCHESDAPEVCVQCLNSdpga-esaDKVGLTTIVVNCLNNHADSLEDKLSNMSSvskdq-----sskdVLMEC 108 Morus notabilis
KDP25096      30 NEDIIECECHNTETPEVCMECLKSnpta-sasNELGIATIITNCVSNHSKHLATKMSVLVHrvgde-----nlksVFQAC 103 Jatropha curcas
NP_001154196  22 EKDMMINECHNADVPAICMQCLESdpns-ihaDHIGIAGIVINCLESHLHIITKQKDKGEVk------------tALEIC 88  thale cress
XP_006422231  28 DDRFIEQMCRDTEVPTLCVQCVKSdpagekadKSTDIAAIAIKCLSNHAEALVKNMSSLAStyssd----kklvaACENC 103 Citrus clementina

Feature 1         ##  #   #                  #           #                                   #  
1XG2_B        76 SENYADAIDSLGQAKQFLt--SGDYNSLNIYASAAFDGAGTCEDSFegpp--nipTQLHQADLKLEDLCDIVLVISNLL 150 Actinidia chinensis
NP_191127    105 GKHYCLASAFFQKAYEEAq-eEGLESIAQLSAVDGSHYMFKCEDEWknng-piqkSPFTFYYTNVVELLSIIQVIIEKM 181 thale cress
NP_567474     96 VTGFAIAQLRLQGANIDLi--TLNYDKAYELVKTALNYPRTCEENLqklk-fkdsSDVYDDILAYSQLTSVAKTLIHRL 171 thale cress
CDY63489     106 KKDLSETMTKALPDAKKGl-kTGEYDKAGQSIKHALGFPLMCGNNLqaae--fvsPTVYSQINIYAQLSDAAMRIIDRF 181 rape
NP_001154430  96 RNDTSTVAPKLLSEAKTGl-kTGDYDKAAKSIEYASIPHSCGLKQPsve---fefLQLFSQISIYTQLSDAAMRIIDRF 170 thale cress
NP_187894    103 GLGFSTAKHGVGEADTQLi-tGDYDKAAYDVSVKVVNPPVSCRNSLealn-iqvpSSFRYHMDVYLALTQALLRIVDRF 179 thale cress
EXB53373     109 SKGYLDSKKDLLSAIVSLk--SDDYDNAEKFVTATLYRHFSCLWSIkknkvvkisSKVACEMRIYEDLCQIADRMIERL 185 Morus notabilis
KDP25096     104 SQGYYLACVDLSMVVSKLk--SGDYDKAGHFVLTALSFQLTCITNFqmnqtwhlpESIAYEMKVYEDLSEAAMRIIDRL 180 Jatropha curcas
NP_001154196  89 KKDLSTNASTILSEAKTSl-kTGDYDKTNKSIKLALGFPLRCMFNLkrvk--ftsPQLFSQINIYAQLSDAAMRIIDRF 164 thale cress
XP_006422231 104 SKGYSQAKKTLSKADAKLkggDYDNANHFVILALSDEFVQRCEPSLepysekqgvYDAFYQIRVYEELTGIALAIIDRL 182 Citrus clementina

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