Conserved Protein Domain Family
FYVE2_PCLO

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cd15776: FYVE2_PCLO 
FYVE-related domain 2 found in protein piccolo
Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.
Statistics
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PSSM-Id: 277315
Aligned: 3 rows
Threshold Bit Score: 128.647
Created: 2-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Zn
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus RIM (2CJS) binds two Zn2+ ions through its FYVE-related domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #                #  #    #  #               #  #           
Q9Y6V0       1003 STCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTp-------HLTENCQTQRAISGQLG 1059 human
Q9PU36        834 VSCPLCKTGLNIGSKDPPNFNTCTECKKVVCNLCGFNPMphivevqeWLCLNCQTQRAMSGQLG 897  chicken
XP_002935303  926 LLCLICQTELNVGSKDPPNFNACTECKKTVCNLCGFNPTphltevkeWLCLNCQTQRAMAGQLG 989  western clawed frog

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