Conserved Protein Domain Family
FYVE_WDFY1
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cd15756: FYVE_WDFY1 
FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar proteins
WDFY1, also termed FYVE domain containing protein localized to endosomes-1 (FENS-1), or phosphoinositide-binding protein 1, or zinc finger FYVE domain-containing protein 17, is a novel single FYVE domain containing protein that binds phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) with high specificity over other phosphoinositides. WDFY1 to early endosomes requires an intact FYVE domain and is inhibited by wortmannin, a PI3-kinase inhibitor. In addition to FYVE domain, WDFY1 harbors multiple WD-40 repeats.
Links
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Statistics
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PSSM-Id: 277295
Aligned: 4 rows
Threshold Bit Score: 176.798
Created: 18-Jul-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  #                       #  #    #  #                  #  #       
Q8IWB7       279 PQWLESDSCQKCEQPFFWNIKQMWDTKTlGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDE 354 human
XP_002936650 278 PQWLESDSCQKCSQPFFWNIKQMWDTKTvGLRQHHCRKCGQAVCGKCSSKRSSYPIMGFEFQVRVCDSCYETIKDE 353 western clawed frog
NP_001007058 279 PQWLDSDSCQKCEQPFFWNIKQMWDTKTlGLRQHHCRKCGKAICGKCSSKRSTYPIMGFEFQVRMCDDCFNTIKED 354 zebrafish
NP_001026481 279 PQWLESDSCQKCEQPFFWNIKQMWDTKTlGLRQHHCRKCGQAVCGKCSTKRSSYPIMGFEFQVSVCDSCFESIKDE 354 chicken

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