Conserved Protein Domain Family
FYVE_RUFY4
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cd15745: FYVE_RUFY4 
FYVE-related domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins
RUFY4 belongs to the FUFY protein family which is characterized by the presence of an N-terminal RUN domain and a C-terminal FYVE domain. The FYVE domain of RUFY4 resembles the FYVE-related domain as it lacks the WxxD motif (x for any residue). The biological function of RUFY4 still remains unclear.
Links
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Statistics
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PSSM-Id: 277284
Aligned: 17 rows
Threshold Bit Score: 52.119
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Zn
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens RUFY1 (2YQM) binds two Zn2+ ions through its FYVE domain.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #                #  #    #    #                                             
Q6ZNE9        520 CCVACSKIFgr----fsRRYPCRLCGGLLC--HACSMdyk---------------------------------------- 553  human
XP_004344154  276 ICSFCARPFgyl---siDKYVCKLCDRAAC--EECCKyavslarstvn-------------------------------- 318  Acanthamoeba ...
EQC42627       25 ACALCQRAFhf----lrHRHVCRMCQGSVC--KQCLSkkppnsv------------------------------------ 62   Saprolegnia d...
ETW02841      253 TCAICSRGFkggmalfqRKVVCRMCEQIVC--KRCSSedkpgg------------------------------------- 293  Aphanomyces i...
XP_002599634  196 FCQLCEQKFgl----ltQKHNCRVCGRVIC--SSCSAenlilyvpddgeqdsdphwaiikvkgcpevepnlclyqhphwa 269  Florida lancelet
EGZ11464      281 LCVNCSRKFsl----fvRKTRCRVCGEVVC--QPCAPqvmistk------------------------------------ 318  Phytophthora ...
XP_004999117  243 ACKICNAGYsf----tkSKTHCRLCGATVCdsDGCSNmlnliemgrltgvm----------------------------- 289  Salpingoeca r...
EQC42459      321 GCRVCLTGFsv----flPAVVCRLCDHDVC--ASCSVlettrq------------------------------------- 357  Saprolegnia d...
EQC42486      312 ACTRCLKRTpl-----rKQVVCRLCGLNFC--HACSSiervest------------------------------------ 348  Saprolegnia d...
ETW00716      359 ACRVCARTFta----fmKQRVCRLCSEVVC--SACSTaqqvpah------------------------------------ 396  Aphanomyces i...

Feature 1                             #  # 
Q6ZNE9        554 ---------------krdRCCPPCA 563  human
XP_004344154  319 -------rtaplategsvRCCKQCS 336  Acanthamoeba castellanii str. Neff
EQC42627       63 -----------klsgrfaKCCHECS 76   Saprolegnia diclina VS20
ETW02841      294 ------------ytrgseRVCHSCL 306  Aphanomyces invadans
XP_002599634  270 iikvkgcpevepnlclyqRVCGSCQ 294  Florida lancelet
EGZ11464      319 ------------rgpvktRVCTKCN 331  Phytophthora sojae
XP_004999117  290 ----rsqpplasdreavvPVCVTCE 310  Salpingoeca rosetta
EQC42459      358 -------------tpialRVCATCV 369  Saprolegnia diclina VS20
EQC42486      349 -----------ngvcfelRVCRVCY 362  Saprolegnia diclina VS20
ETW00716      397 ------------dvvveiRVCVACV 409  Aphanomyces invadans

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