Conserved Protein Domain Family
FYVE_RABE_unchar
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cd15739: FYVE_RABE_unchar 
FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria
This family includes a group of uncharacterized rab GTPase-binding effector proteins found in bilateria. Although their biological functions remain unclear, they all contain a FYVE domain that harbors a putative phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding site.
Links
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Statistics
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PSSM-Id: 277278
Aligned: 13 rows
Threshold Bit Score: 128.614
Created: 6-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #             #  #    #  #                 #  #             
NP_498266    338 EVRWQWDDDVDQCSNCDTSFar-vkVKPHCLHCGRIFCMNCLKDTVPSGPNHRP-ANVCKVCHTLLNRDTKPFFA 410  nematode
NP_611545    557 EVRWQDDDDVNNCPTCNAYFtv-mvRKIHCRHCGHIYCDKCLTKTVPSGPRKRV-ARVCDICHTLLTPNTAPYFS 629  fruit fly
XP_005107499 871 EVRWQHEDDVDDCSNCKQPFtv-tkRKHHCRHCGKIFCSDCTTKSVNSGPNFRP-SKVCDVCHTILVKDATPYFS 943  California sea hare
AAM80557     346 EVRWEDDDDVLMCRGCKQLFnr-hrRKLHCRHCGRIFCDPCLSRTVSSGPQRKP-AKVCEVCHTLLVSETAPYFS 418  Trichinella spiralis
XP_002404982 673 EVRWQHEDDVGECNTCKRGLha-rkEKHHCSHCGKIFCIECLGKAVRSGPKMRS-FPVCNVCHTLLDHDTAPYFS 745  black-legged tick
EFX69086     713 ELRWQYEEDIDQCAECRQAFgv-akRKHHCRHCCQIFCGDCLRKTVTSGPNKRQ-SRVCNVCFYLLVQESAPFFS 785  common water flea
XP_789966    917 EVRWQHEDDADKCNNCKTAFgsskkKKNHCKHCGKLFCADCVTKSVESGPRRRK-MPVCDVCHTLLVNESAPYFS 990  purple urchin
EJW84609      87 EVRWQFDEDVHACNQCQSKFsk-nrVKFHCYHCGKIFCSICLSATIPSGPHRRP-ARVCQVCHTLLSRDSAPFFS 159  agent of lymphatic ...
ELT92380     183 EVRWQHEEDIDDCTNCKQSFsv-tkRKHHCKHCGRIYCSDCITKSVNSGPNLRP-SKVCDVCHTVLVKDATPYFS 255  Capitella sp. I Gra...
ENN77973     557 QVRWQHEEDIEECSNCHIPFsn-skRKQHCRHCGQIFCPNCVARVVQSGPNMRP-SHVCDVCYTLLVKTSAPYFS 629  mountain pine beetle
EHJ76634     509 EVRWQHDEDVSECPACRTPLpt-nkKKIHCRHCGRIFCGPCVSQVVASGPRGLP-ARVCSVCRTLLQPHAAPYFS 581  monarch butterfly
CDJ18965     351 EVRWQDPEDVTQCPGCKRPFea-gmVKRNCRHCGAIFCPACLTKVIPPFGARSRpARVCDMCHTLLVKDAAPYFC 424  Echinococcus granul...
GAA56141     668 ELRWVDPDDVATCFACTTPFhs-gsRKINCPHCGKVHCQNCMKNTVSSGPSGRL-ARVCDVCHTLLNKHVAPYFS 740  Clonorchis sinensis

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