Conserved Protein Domain Family
FYVE_MTMR_unchar
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cd15738: FYVE_MTMR_unchar 
FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
This family includes a group of uncharacterized myotubularin-related proteins mainly found in eumetazoa. Although their biological functions remain unclear, they share similar domain architecture that consists of an N-terminal pleckstrin homology (PH) domain, a highly conserved region related to myotubularin proteins, a C-terminal FYVE domain. The model corresponds to the FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.
Links
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Statistics
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PSSM-Id: 277277
Aligned: 16 rows
Threshold Bit Score: 86.9978
Created: 6-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Zn
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #  #            #  #    #  #                       #  # 
NP_726322    693 VDWKPMRNvtTC-SCSTPFdqfsKKTHCWRCGDIFCERCIDknvalpg-----hdsgkpvPVCRGCF 753 fruit fly
ELU00050     624 TEWRSLRNvkNC-SCAMPFeqytKKHHCWRCGSIYCTRCIDrymplsg-----hdskrpvPVCKACF 684 Capitella sp. I Grassle & Gr...
XP_002611743 685 LEWKAFRNirQC-SCETPLdafnKKYHCWRCGDIFCTRCIDkqtpipg-----hysqrpvPVCRTCY 745 Florida lancelet
XP_003738894 627 LKWMSLRKpvQC-PCALPVdcssRKFHCWSCGGIYCGRCLDgqlalpg-----hlsgrsvTVCRACF 687 western predatory mite
JAA59918     624 VDWKSFRNikEC-PCSTPFdhfrRKFHCWSCGDVFCIRCIDkrlclpg-----hmtkrpvPVCRHCY 684 Rhipicephalus pulchellus
ENN74754     580 IDWKAMRSsnEC-NCTSAFdhlsKKNFCRKCGDMFCMRCLTkqmvlpg-----hlsqkpvPVCKPCF 640 mountain pine beetle
XP_003245820 643 IEWKSLREavSC-ECSTDSs--tKKYHCWKCGNVFCTRCINmnvslpg-----hlsqdpvPVCHGCH 701 pea aphid
EHJ64211     620 LDWKTIKNvtEC-GCSTPLdhfsRKHHCWGCGRVVCTRCVAaraalpa-----lhaaraaPLCAACA 680 monarch butterfly
EZA45258     602 LDWKTSSKveEC-SCCSTFdafnKKNHCWSCGNVFCIRCIEeeprslsg----hlsqrvvPRCKSCS 663 Microplitis demolitor
XP_004998993  58 VHWQAPTDtdKCrACGAGFdlidRRHWCRRCGHIHCKRCMRqqrkldirarpdpisgthqPVCFQCY 124 Salpingoeca rosetta

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