Conserved Protein Domain Family
FYVE_ZF21
?
cd15727: FYVE_ZF21 
FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
ZF21 is phosphoinositide-binding protein that functions as a regulator of focal adhesions and cell movement through interaction with focal adhesion kinase. It can also bind to the cytoplasmic tail of membrane type 1 matrix metalloproteinase, a potent invasion-promoting protease, and play a key role in regulating multiple aspects of cancer cell migration and invasion. ZF21 contains a FYVE domain, which corresponds to this model.
Links
?
Statistics
?
PSSM-Id: 277266
Aligned: 14 rows
Threshold Bit Score: 92.0557
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #             #  #    #  #                  #  #  
Q9BQ24        38 EPQWVPDkeCRRCMQCDAKFDFLt-RKHHCRRCGKCFCDRCCSQKVplrrmcFVDPVRQCAECAL 101 human
XP_002610207  36 EPPWVPDseCSQCMSCKAKFDFVk-RKHHCRRCGKCYCDKCCQHKValprlcFLDPVRLCYDCAV 99  Florida lancelet
XP_002429207  38 EPYWVPDneISHCTSCKGKFNFTk-RKHHCRRCGRIYCSSCSCYRIplprmsFVDPVRVCNNCAD 101 human body louse
NP_001087519  34 EPPWVPDkeCPRCMHCDAKFDFIt-RKHHCRRCGKCFCDKCCSKKVplprmcFVDPVRQCGECSV 97  African clawed frog
NP_001071895  34 EPQWVSDkdCNACESCKKSFDFFn-RRHHCRRCGLCFCDNCTHYVLplkrmyFMDPVRHCYDCAV 97  Ciona intestinalis
XP_001199278  33 EPPWIPDeqCHYCMKCQAKYDLVk-RRHHCRRCGKCFCGPCCSTKVllprmnFVDPVRLCEECAT 96  purple urchin
EKC41310      32 EPPWVPDdeCKQCQNCRGKFDFFkrRKHHCRRCGRCFCNDCCQEKVnlprmqFLDPVRHCQVCTE 96  Pacific oyster
ELT95451      32 EPPWVPDkeCPQCLSCTVKFDFLh-RRHHCRRCGRCFCGSCSNNNIvlhrmcFVDPVRHCKDCVP 95  Capitella sp. I Grassle & Gras...
ESO02065      31 EPTWIPDkqIQSCSLCQTKFDLFn-RKHHCRRCGTCICRKCCHNRPlpr-mcFIDPVLQCNLCSL 93  Helobdella robusta
XP_001321636 334 APVWIPDdqAPVCMECQKKFTLFf-RRHHCRRCGKCICSDCFKNQIrip-giSESPKHVCNECYK 396 Trichomonas vaginalis G3

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap