Conserved Protein Domain Family
FYVE_RBNS5
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cd15716: FYVE_RBNS5 
FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
Rbsn-5, also termed zinc finger FYVE domain-containing protein 20, is a novel Rab5 effector that is complexed to the Sec1-like protein VPS45 and recruited in a phosphatidylinositol-3-kinase-dependent fashion to early endosomes. It also binds to Rab4 and EHD1/RME-1, two regulators of the recycling route, and is involved in cargo recycling to the plasma membrane. Moreover, Rbsn-5 regulates endocytosis at the apical side of the wing epithelium and plays a role of the apical endocytic trafficking of Fmi in the establishment of planar cell polarity (PCP).
Links
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Statistics
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PSSM-Id: 277256
Aligned: 14 rows
Threshold Bit Score: 96.6438
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #            #  #    #  #                                        
Q9H1K0       151 VVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLplankltsaskeslsthtspsqspns-------- 222 human
XP_786891    155 IVPWAEDSDVRFCPSCGDKFSLAVRRHHCRLCGSIMCNKCSSYVGIpfcdqvleaeskgstss----------------- 217 purple urchin
XP_002601782 152 LVPWAPDDAVPYCPTCGEKFNLSRRRHHCRLCGGIMCNRCSQFLTPdftaklvnkagnlpvqtirgeekghrr------- 224 Florida lancelet
CAG11329     143 VVSWVNDSDVPFCPDCGNKFNIRNRRHHCRLCGSIMCRKCMEFVPLplaqklisgtrealciagspvhsqslpsggg--- 219 spotted green p...
XP_002122676 139 LVPWVRDVDVPYCPTCGDRFNVARRRHHCRLCGSIMCTKCSLFVQLeladqlveslrkvpgmrkrt-------------- 204 Ciona intestinalis
XP_001631107 144 LVPWVADSEVDFCPICKKSFNLARRRHHCRLCGGIICAKCSISVAVnfagkeasasrevicerlkld------------- 210 starlet sea ane...
EFN80700     139 IVPWIDEKDVKLCPNCAKSFHLARRKHHCRLCGAVMCHNCTLFLSLvnarkmtspvsvqddsalpltseralserivrag 218 Harpegnathos sa...
EFX71373     148 IVTWVNDEDVQLCPQCAKSFNILRRKHHCRVCGTVQCHQCSQFLLLsfarkltnpsyiptlddnkekpsppkrlth---- 223 common water flea
EGD81826      54 VVPWVDGNMVPRCPECAVRFSLARRRHHCRLCGAVICNDCSLGLDVgaavsltvsprladarktpkea------------ 121 Salpingoeca sp....
AEO33720      84 LVPWVEDADVKLCPSCAKSFSISRRRHHCRLCGGIMCQMCSEFLDSatvqqlvast------------------------ 139 Amblyomma macul...

Feature 1                                          #  #       
Q9H1K0       223 -----vhgsrrgsissmssvssvldekdddRIRCCTHCKDTLLKR 262 human
XP_786891    218 --------------kqvhaesspskkgdvvTLRVCEHCVHIMEKR 248 purple urchin
XP_002601782 225 ---qgsagtrameslrslvgevvgeepredGTRTCQDCMAVMGRR 266 Florida lancelet
CAG11329     220 sssssgmgprrgsisslssvtsmleekddeKIRCCHHCMDKLLKR 264 spotted green pufferfish
XP_002122676 205 ----------qsdlnlsrsasmsssqdeeiSLRCCHDCYVVLMKR 239 Ciona intestinalis
XP_001631107 211 ----------ksadlpqgskrrsrddtdepGIRACQVCKILYSRY 245 starlet sea anemone
EFN80700     219 vgltklarspssgslnsvlslvndsasseqHFRVCMHCMNLLDAR 263 Harpegnathos saltator
EFX71373     224 -aafhalkrtgsttsltsltslidtdtgegHIRVCYYCKQLLERR 267 common water flea
EGD81826     122 ---------eaerqrriaqkkrklaleetsCIRICPFCQTSLHRS 157 Salpingoeca sp. ATCC50818
AEO33720     140 --------------------ggpaanvgdePLRLCRDCRVLLDRR 164 Amblyomma maculatum

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