Conserved Protein Domain Family
ePHD1_PHF6
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cd15710: ePHD1_PHF6 
Extended PHD finger 1 found in PHD finger protein 6 (PHF6)
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. PHF6 contains two non-canonical ePHD fingers, this model corresponds to the first ePHD finger. PHF6, also termed the X-linked mental retardation disorder Borjeson-Forssman-Lehmann syndrome-associated protein, is a nucleolus, ribosomal RNA promoter-associated protein that regulates cell cycle progression by suppressing ribosomal RNA synthesis. It has been implicated in cell cycle control, genomic maintenance, and tumor suppression. PHF6 shows transcriptional repression activity through directly interacting with the nucleosome remodeling and deacetylation complex component RBBP4. .
Links
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Statistics
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PSSM-Id: 277180
Aligned: 4 rows
Threshold Bit Score: 219.062
Created: 5-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                     #  #                                    #  #        #  
Q8IWS0        17 CGFCKSNRDKECGQLLIsenQKVAAHHKCMLFSSALVSSHSDnESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDV 96  human
NP_956059     15 CAFCRTNRDKECGQLLVaesHRVAAHHKCMLFSSALVTSHSDsENIGGFSIEDVKKEIKRGNKLMCTSCHRPGATIGCDV 94  zebrafish
ETE63633      17 CGFCRSNKEDECGQLMLsenQKVAAHHKCMLFSSALVSSHTDnESLGGFSIEDVQKEIKRGTKLKCSLCHCPGATIGCDV 96  king cobra
NP_001088235  18 CGFCRSNREKECGHLLIssnQKVAAHHRCMLFSSALVSSQSDsENLGGFSIEDIQKELKRGKKLMCSLCHCPGATIGCDV 97  African clawed ...

Feature 1          #    #  #                    #  #
Q8IWS0        97 KTCHRTYHYHCALHDKAqIREKPSQGIYMVYCRKH 131 human
NP_956059     95 KTCRRTYHYYCALWDKAqTKENPSQGIYLVYCRKH 129 zebrafish
ETE63633      97 KTCHKTYHYYCALHDQAqIREKPSQGIYMILCRKH 131 king cobra
NP_001088235  98 KSCHRSYHYHCALRDKAhIQENPSQGMYTIFCRKH 132 African clawed frog

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