Conserved Protein Domain Family
ePHD_AF17
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cd15709: ePHD_AF17 
Extended PHD finger found in protein AF-17 and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model includes the ePHD finger of AF-17. AF-17, also termed ALL1-fused gene from chromosome 17 protein, is encoded by gene AF17 that has been identified in hematological malignancies as a translocation partner of the mixed lineage leukemia gene MLL. It is a putative transcription factor that may play a role in multiple signaling pathways. It is involved in chromatin-mediated gene regulation mechanisms. It functions as a component of the multi-subunit Dot1 complex (Dotcom) and plays a role in the Wnt/Wingless signaling pathway. It also seems to be a downstream target of the beta-catenin/T-cell factor pathway, and participates in G2-M progression. Moreover, it may function as an important regulator of ENaC-mediated Na+ transport and thus blood pressure. AF-17 contains an N-terminal plant homeodomain (PHD) finger followed by a non-canonical ePHD finger.
Links
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Statistics
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PSSM-Id: 277179
Aligned: 4 rows
Threshold Bit Score: 258.84
Created: 19-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #                #  #                               #  #                #
P55198         61 ARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTC 140  human
EMP33807       61 ARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFSKTCYICEEQGRESKAASGACMTC 140  green sea turtle
NP_001016795   61 ARVRCDLCPHKEGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQFVPHDRFNKTCYICEDQGRESRAASGACMTC 140  western clawe...
ETE68873       61 ARVRCELCPHKDGALKRTDSGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTC 140  king cobra

Feature 1             #    #  #                       #  #     
P55198        141 NRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMK 185  human
EMP33807      141 NRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFNKMK 185  green sea turtle
NP_001016795  141 NKHGCRQAFHVTCAQMAGLLCEEEAQEVDNVKYIGYCKYHFNKMV 185  western clawed frog
ETE68873      141 NRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFNKMK 185  king cobra

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