Conserved Protein Domain Family
ePHD_JADE2
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cd15705: ePHD_JADE2 
Extended PHD finger found in protein Jade-2 and similar proteins
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model includes the ePHD finger of Jade-2. Jade-2, also termed PHD finger protein 15 (PHF15), is a plant homeodomain (PHD) zinc finger protein that is closely related to Jade-1, which functions as an essential regulator of multiple cell signaling pathways. Like Jade-1, Jade-2 is required for ING4 and ING5 to associate with histone acetyltransferase (HAT) HBO1 and Eaf6 to form a HBO1 complex that has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. Jade-2 contains a canonical PHD finger followed by this non-canonical ePHD finger, both of which are zinc-binding motifs.
Links
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Statistics
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PSSM-Id: 277175
Aligned: 4 rows
Threshold Bit Score: 248.087
Created: 5-Mar-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #  #                 #  #                                #  #         #    #    
Q9NQC1    254 CLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAF 333 human
AAH97813  253 CLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPPSRWALSCSLCRECTGTCIQCSMPSCITAF 332 African clawed frog
XP_697831 249 CLLCPRRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKVSHIPASRWALSCSLCCEHSGTCIQCSMPSCTVAF 328 zebrafish
EMP41607   26 CLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPACITAF 105 green sea turtle

Feature 1     #  #                       #  #
Q9NQC1    334 HVTCAFDHGLEMRTILaDNDEVKFKSFCQEH 364 human
AAH97813  333 HVTCAFDHNLEMHTTLsENDEVKFKSFCLEH 363 African clawed frog
XP_697831 329 HVTCAFDHGLEMRTTLaDNDEVRFKSYCLEH 359 zebrafish
EMP41607  106 HVTCAFDHNLDMRTILaENDEVKFKSFCLEH 136 green sea turtle

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