Conserved Protein Domain Family
PHD1_DPF1
?
cd15690: PHD1_DPF1 
PHD finger 1 found in D4, zinc and double PHD fingers family 1 (DPF1)
DPF1, also termed zinc finger protein neuro-d4, or BRG1-associated factor 45B (BAF45B), is encoded by a neuro specific gene, neuro-d4. It may be involved in the transcription regulation of neuro specific gene clusters. DPF1 contains a nuclear localization signal in the N-terminal region, a Cys2His2 (C2H2) zinc finger or Kruppel-type zinc-finger and a sequence of negatively charged amino acids in the central, and a cysteine/histidine-rich region that is composed of two adjacent plant homeodomain (PHD)-fingers (d4-domain) in the C-terminal part of the molecule. The family corresponds to the first PHD finger.
Links
?
Statistics
?
PSSM-Id: 277160
Aligned: 4 rows
Threshold Bit Score: 117.456
Created: 14-Aug-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human transcriptional protein DPF3 (2KWJ) binds two Zn2+ ions through its first PHD finger
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #               #  #    #  #                 #  # 
Q92782       252 IPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECK 309 human
NP_001090745 265 IANGYCDFCLGGAKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECK 322 western clawed frog
XP_005173437 289 IPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECK 346 zebrafish
XP_005279258 205 IPNGYCDFCLGGAKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECK 262 western painted turtle

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap