Conserved Protein Domain Family
PHD_JADE2
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cd15680: PHD_JADE2 
PHD finger found in protein Jade-2 and similar proteins
Jade-2, also termed PHD finger protein 15 (PHF15), is a plant homeodomain (PHD) zinc finger protein that is closely related to Jade-1, which functions as an essential regulator of multiple cell signaling pathways. Like Jade-1, Jade-2 is required for ING4 and ING5 to associate with histone acetyltransferase (HAT) HBO1 and Eaf6 to form a HBO1 complex that has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. Jade-2 contains a canonical Cys4HisCys3 PHD finger followed by a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, both of which are zinc-binding motifs. This model corresponds to the canonical Cys4HisCys3 PHD finger.
Links
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Statistics
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PSSM-Id: 277150
Aligned: 6 rows
Threshold Bit Score: 103.548
Created: 30-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on structure evidence that human BRD1 (2KU3) binds two Zn2+ ions through its PHD finger.
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3.
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #             #  #    #  #            #  #
Q9NQC1       201 VCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTC 246 human
EMC78170     201 VCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPIGSWLCRTC 246 rock pigeon
AAH97813     200 VCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILNVPTGSWLCRCC 245 African clawed frog
XP_697831    196 VCDVCRSPEGEDGNEMVFCDNCNVCVHQACYGILKVPQGNWLCRTC 241 zebrafish
XP_005989402 218 VCDVCRSPEGEDGNEMVFCDKCNICIHQACYGILKVPTGSWLCRTC 263 coelacanth
XP_007899488 209 VCDVCRSPEGEDGNEMVFCDKCNICVHQACYGILKVPLGSWLCRTC 254 elephant shark

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