Conserved Protein Domain Family
PHD_BRPF3
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cd15678: PHD_BRPF3 
PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
BRPF3 is a homolog of BRPF1 and BRPF2. It is a scaffold protein that forms a novel monocytic leukemic zinc finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complex with other regulatory subunits. BRPF3 contains a canonical Cys4HisCys3 plant homeodomain (PHD) finger followed by a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. This model corresponds to the canonical Cys4HisCys3 PHD finger.
Links
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Statistics
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PSSM-Id: 277148
Aligned: 4 rows
Threshold Bit Score: 122.05
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on structure evidence that human BRD1 (2KU3) binds two Zn2+ ions through its PHD finger
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3.
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #             #  #    #  #            #  #       
Q9ULD4        212 DAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRP 266  human
XP_005169382  248 DAYCCVCLDDECLNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRRCLQSPSRP 302  zebrafish
EMP32317      212 DAVCCVCMDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRP 266  green seaturtle
NP_001128279  216 DAFCCVCLDDECHNSNAILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSKP 270  western clawed frog

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